Product Details: BenaGene

benaGene DISCUSSION: benaGeneTM contains a key intermediate in the Kreb's Cycle. Studies demonstrate that benaGene mimics a caloric restriction diet, which has been shown to increase the expression of beneficial genes associated with increased life span, health span, weight management and blood glucose reduction.
30 Vegi-Caps AOR04138
100% Vegetarian
SUPPLEMENT FACTS:
Serving Size: 1 Capsule
benaGeneTM (3-carboxy-3-oxopropanoic acid) 100mg

Vitamin C

 100mg
*Dietary Reference Intake not established.
Non-medicinal ingredients: Microcrystalline cellulose. Capsule; hypromellose, water.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, soy, eggs, dairy, fish or shellfish.

Suggested Use
Take one capsule daily with food or as directed by a qualified health care practitioner. Do not use during pregnancy and lactation.

Main applications
As reported by literature:
• Anti-Aging.
• Glucose metabolism.

Source
Pharmaceutical synthesis.

Pregnancy / Nursing
Do not use during pregnancy and lactation.

Cautions
Do not use during pregnancy and lactation.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2005, Advanced Orthomolecular Research

 


benaGene Immortality is an age old Holy Grail. A phenomenon of the ego. A topic best left to science fiction and Hollywood. The search for it is often beset with tragedy, as was the case of Juan Ponce De Leon and his quest for the legendary fountain of youth.

However, life extension is a realistic goal and a proven physiologic phenomenon in diverse organisms through various interventions, such as exposure to certain stresses (ionizing radiations, heat or osmotic shock) or caloric restriction.
There are several ways of extending life span but the key is to match the gain in years with a corresponding increase in vigour and vitality. In other words, adding years to life has to be concurrent with adding life to years. Ideally increasing both maximal life span and health span. The latter can be assessed by monitoring various disease-risk markers such as lowered blood glucose levels, Hb1Ac, isoprostane F2, reactive oxygen and nitrogen species, lipid markers, age-amadori adducts, and different inflammatory markers such as C-reactive proteins.

The process of aging has been ascribed to various mechanisms including: (1) increased metabolism and thus increased production of reactive oxygen species, (2) reduction of apoptosis (or programmed cell death), (3) increased glucose/insulin and insulin-like growth factor 1 (IGF-1) signalling molecules, (4) disruption of the daf-2 pathway, (5) effect of longevity genes (including FOXO, Sir-2, and INDY (I am not dead yet)), (6) NAD+/NADH ratio, and others.

Caloric restriction optimal nutrition (CRON) extends life and health span in a wide variety of organisms and has been shown to delay the onset or reduce the incidence of many age-related diseases, including cancers, diabetes, cardiovascular diseases and neurological diseases (including Parkinson's and Alzheimer's). Furthermore, a significant improvement in various disease risk parameters has been conclusively shown in humans.

Thanks to the pioneering work of professors Leonard P. Guarente (of the Massachusetts Institute of Technology) and David A. Sinclair (of Harvard University), research has revealed that certain longevity genes are activated during caloric restriction. Moreover, their work showed that this effect was evident at any age; in other words, life extension could be achieved in older age groups as well. Gurante and other researchers believe that this effect may be related to the critical ratio of the ubiquitous co-enzymes NAD+ (the oxidized form of NAD, or nicotinamide adenine dinucleotide) and its reduced form NADH. NAD is a niacin-derived coenzyme that is present in all living cells and is critical to the production of ATP - the body's primary source of all immediate energy. Higher NAD+ levels are thought to have a stimulatory effect on the beneficial genes whilst a high NADH concentration is thought to inhibit such genes. Hence a high NAD+/NADH ratio may prolong life and health span.

BenaGeneTM is a novel caloric restriction mimetic (CR mimetic). It mimics the changes in the expression of over 350 genes in a similar fashion to caloric restriction and thus may be considered a true nutrigenomic compound. The resulting (and astonishing) increases in average and maximal life span, reduction in weight, and reduction in glucose levels have been observed in various species.

Human clinical trials have confirmed both reduction in glucose levels and an improved uptake of glucose without negative side effects (and hence an effective hypoglycaemic agent). BenaGeneTM work on a "biological diode" thereby increasing the conversion of NADH to NAD+ as well as on resulting changes in the electrical state (Gibbs free energy) and critical signalling molecules.

BenaGeneTM is the world's first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bio-available so that a one-a-day dosage is all that is required, offering the potential of life and health extension.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2005, Advanced Orthomolecular Research

 


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Public FAQs

Q: Are there any side effects associated with benaGene?
A: Side effects reported other than an increase in lifespan and better glucose management include the following: 1) Reduction in sugar cravings. 2) Improved energy. 3) Improvement in sleep. 4) Reduction in constipation. 5) Reduction in the ability to create and store fat.

Q: I Have Heard That Sorbitol Can Be Potentially Dangerous To Diabetics. Is This True?
A: No. The root of the question is not entirely without merit, however, since sorbitol is structurally a sugar alcohol. However, any problem posed by excess cellular sorbitol for diabetics is that it is actually caused by excess glucose in the cell (which is converted to sorbitol in the body), and this pertains to ENDOGENOUS sorbitol. When EXOGENOUS sorbitol is introduced from capsules, the liver converts this sorbitol into glucose, leading some to believe that this can have negative metabolic implications. However, much of this sorbitol (up to 75%) is converted to CO2 and is released as perspiration. Furthermore, the amount of sorbitol found in a typical capsule is approximately 8-14 mg, and even if the conversion to glucose was complete, this would lead to an increase of blood glucose levels of 300 mcg/dl. To put that number into proper perspective, normal fasting glucose levels are 140 mg/dl, and normal non-fasting levels are approximately 400 mg/dl. These numbers represent approximately one-466th and one- 1333rd respectively the difference the amount of sorbitol in a capsule could possibly make, a negligible number brought into even clearer perspective given the fact that most glucometers are accurate to within 10-15%. Adcock LH, Gray CH. The metabolism of sorbitol in the human subject. Biochem J. 1957 Mar;65(3):554-560.

Q: If I am taking resveratrol, should I also take benaGene?
A: Resveratrol is thought to work by stimulating the Sirtuin proteins which use NAD+ as a substrate. benaGene works by making more NAD+ available. The two compounds can work synergistically.

Q: What is benaGene?
A: benaGene is composed of two compounds already found within your body: the bio-identical human metabolite 3-carboxy-3-oxypropanotic acid (3C3O) and Vitamin C. 3C3O is central to metabolism and is found in every cell of your body.

Q: What is Sorbitol and Why Is It Used In AORs Capsules?
A: Sorbitol, also known as glucitol, is a highly ubiquitous and naturally-occurring substance found in everything from the biochemistry of the human body to apples to chewing gum. The latter of course contains the synthetic version, and in the supplement industry sorbitol is used in capsules, tablets and softgels. Its most common roles are that of a plasticizer (to reduce capsule brittleness and enhance stability) and as a humectant (to reduce long-term leakage). Sorbitol is one of the most effective and widely used substances in the world for these and other similar purposes, spanning the food, pharmaceutical, and natural supplement industries. It holds GRAS (Generally Recognized As Safe) status with the FDA in the United States and in Canada is listed on the Ministry of Health's list of Acceptable Non-medicinal Ingredients with a composition allowance of 90%, one of the highest of any non-medicinal ingredients. However, as of March of 2009, the capsules of AOR products will no longer contain sorbitol as a constituent.

Q: Why should I take benaGene?
A: There are several reasons: 1)Within the last five years, there have been several studies by major universities documenting that an increase in the NAD+/NADH ratio results in statistically significant increases in lifespan and health-span in laboratory animals. Equally as exciting, this same increase in the NAD+/NADH ratio has also been shown to increase individual human cell lifespan in vitro. benaGene is a bio-identical human metabolite that increases the NAD+/NADH ratio, and has been proven to result in > 20% increase in lifespan in laboratory animals (p < 0.001). Health-span of the animals is also remarkably increased. 2)Clinical trials using 3C3O have documented significant glucose level reductions in diabetic patients. A separate study in non-diabetic patients documented a reduction in the amplitude of glucose swings, allowing better overall blood sugar management. No negative side effects were reported. Although benaGene lowers high glucose levels, it does not cause hypoglycemia (abnormally low glucose levels) in non-diabetic patients. 3)3C3O is a powerful anti-oxidant, and has been shown to protect neurological tissue, pancreatic tissue and eye tissue.