Can Curcumin Help Improve Mood in Just One Dose?

Published on November 16, 2014 by Justine Florence

By now, I’m sure that most of us health buffs have heard about curcumin. Curcumin research has dominated the science and nutraceutical field for quite some time because in vitro and animal studies on curcumin have been so promising. Curcumin has experienced clinical success in human studies in the areas of: depression, cancer, enlarged prostate, osteoarthritis, cholesterol, cardiovascular health, metabolic health, GI inflammation, autoimmunity, gallbladder, toxicity, dental health, surgical recovery, and more. For some reason though, it hasn’t spilled over into the media as much as one might expect. Perhaps this is because the results haven’t been quite as miraculous as we hoped they would be: but we now know that this was mainly due to inadequate dosing and formulation problems. I’m not quite sure why clinical studies keep being published that are using a plain-Jane curcumin extract when there is so much evidence showing that a bioavailable curcumin formula is far more effective!

One of the latest, most relevant potentials for curcumin is for its protective effects on the brain. Curcumin was supposed to be the revolutionary treatment in the fight against Alzheimer’s disease due to its ability to bind and remove beta-amyloid plaque from the brain. Unfortunately, no clinical studies have been able to show this effect in humans.

UCLA (the University of California, Los Angeles) has done close to 2 decades of research on solving the curcumin conundrum: how to make it do what we know it’s capable of! And they may have found the answer. A new study using an optimized curcumin formula has recently been published showing that it improved cognitive function and mood over 30 days, taking just one capsule a day! (Actually, cognitive improvements were noted just 1 hour after taking the first dose, but this would be too crazy for most to believe.) Another study showed that this same optimized curcumin reduced blood levels of beta-amyloid proteins in healthy people in just 30 days!

What this shows is that certain curcumin formulas allow curcumin to get into the brain and do its job. Scientists are beginning to think that only free-form curcumin can get from the blood into the brain, and it appears that the formula developed by UCLA does just that. And if we have finally found a way to get curcumin into the brain, perhaps human clinical studies in Alzheimer’s disease patients will finally be successful…. At last, there is hope!

Have you tried Curcumin? If you have, how do you use it and what effects have you noticed? Tell us in the comments below or tweet us @AOR_Health!

Image by © 2013 Alliance via DollarPhotoClub


Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct 2.
Disilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79.
Hamaguchi T, Ono K, Yamada M. REVIEW: Curcumin and Alzheimer’s Disease. CBS Neuroscience and Therapeutics. 2010; 16(5): 285-297.

  • Margaret Moule

    I took my first dose of curcumin at bedtime. I couldn't sleep well that night, possibly because it energized me? Since then, I've taken it during the day instead, & haven't noticed any particular immediate effects. But, since you're asking, I'll try to be more aware & write myself a little note to monitor how I feel following ingestion of the pill......will let you know in time..........i'm 66 yrs. & hope to have a good brain for some years yet! Margaret Moule.