The skin is one of the largest organs in the body and has a variety of cells including: keratinocytes, sebaceous glands, fibroblasts, melanocytes, adipocytes (fat cells) and so on. These cells in turn have a large range of receptors among others, endocannabinoid and related receptors like CB1, CB2, TRPV1, PPAR, COX, opioid, TLR, GRP55, GPR119 etc. Observational reports from the 1990s showed that when cannabis, hashish and other variants of cannabis were abused, there was accompanied skin disorders like hair loss, acne, ageing, dermatitis, dry skin etc. These observations indicated that cannabinoids may modulate these receptors and that using the
Three new studies provide further evidence of the effectiveness of the unique molecule-curcumagalactomannoside complex (CGC) which is one of the key ingredients used in AOR’s Curcumin Ultra softgels. Building on the already impressive body of work, the first study compared once a day 400 mg of CGC containing 130 mg of curcumin against the standard combination of 500 mg of glucosamine and 415 mg of chondroitin sulphate taken twice daily dose (total daily dose of 1000 mg glucosamine and 830 mg chondroitin sulphate) in terms of effectiveness in patients with osteoarthritis. This was a six-week, 72 patient study. In the
Curcumin is a well-studied herb, and as such there are thousands of different products on retailer’s shelves. Moreover, there are dozens of different brands with serious marketing dollars towards differentiating their brands and, touting their effectiveness. Curcumin belongs to a group called curcuminoids comprising three slightly different molecules that are extracted from the root or rhizomes of the Curcuma plant. Curcumin comprises over 80% of this group and is the most researched molecule, and therefore, everyone refers to curcumin when they really mean the curcuminoid group. Virtually all the products on the market consist of this curcuminoid group, and not
When it comes to joint health the conversation often centers around structural support – reinforcing, lubricating, and soothing the joint space. Healthy joints are protected and cushioned by layers of connective tissue called cartilage that allows them to move freely without any grinding or contact between the bone surfaces themselves. A special fluid in the joint capsule, called synovial fluid, is also extremely important for joint function. It acts as a natural lubricant and cushions joint movement. In conditions such as osteoarthritis, injury, and even in aging, there is a reduction in synovial fluid and a loss of cartilage that
Pain is a subjective perception influenced by numerous factors. Pain sensitivity can be vastly different from one person to the next. Some influences on pain sensitivity include psychological and neurobiological factors, but gender and sex hormones also play a very particular role. Researchers have found that there are actual differences in how men and women experience severity of pain, because sex hormones are involved in pain transmission and sensitivity. Specifically, estrogen is linked to visceral pain sensitivity. That is, pain that is diffuse and poorly localized. In multiple disorders that involve visceral pain, such as irritable bowel syndrome (IBS) and
The endocannabinoidome (eCBome) is a broader and more appropriate term than the old endocannabinoid system (ECS), and incorporates the more recent research into this fascinating area. What is the eCBome Briefly, eCBome is a protective, and communication network that exists all over the body, and interacts with hormonal, nervous, immune, endocrine, microbiome, and other systems of the body. The eCBome plays a major role in the health and disease of many organs of the body including; the reproductive system in both males and females, hormonal system, kidneys, liver, gut microbiome, heart and circulatory system, nervous system, skin among other tissues.
Most of us have had the unpleasant opportunity to experience a fractured bone at some point in our lives. As children, we’re constantly running, falling and bumping into one another on the playground. Adulthood tends to bring less activity, but many other factors that increase the risk of fracture, mainly lower bone mineral density. Being handicapped by a broken bone can lead to missed days of school or work, depressed mood, missed social events, and overall poorer quality of life. This is why it’s so important to speed up the recovery process! There are many factors that contribute to the
Chronic pain is one of the most common health concerns for which people seek medical treatment. Research suggests that up to 50% of the population may be suffering from some kind of chronic pain, with back pain being the most common.1 There are a number of possible causes that may contribute to chronic pain including: diet, posture, age, and injury. Vitamin D is another factor that is now being added to that list. Vitamin D deficiency is a very common occurrence, especially in people living in colder climates. It has been linked to numerous health conditions, one of those being