Pain is a subjective perception influenced by numerous factors. Pain sensitivity can be vastly different from one person to the next. Some influences on pain sensitivity include psychological and neurobiological factors, but gender and sex hormones also play a very particular role. Researchers have found that there are actual differences in how men and women experience severity of pain, because sex hormones are involved in pain transmission and sensitivity. Specifically, estrogen is linked to visceral pain sensitivity. That is, pain that is diffuse and poorly localized. In multiple disorders that involve visceral pain, such as irritable bowel syndrome (IBS) and
The endocannabinoidome (eCBome) is a broader and more appropriate term than the old endocannabinoid system (ECS), and incorporates the more recent research into this fascinating area. What is the eCBome Briefly, eCBome is a protective, and communication network that exists all over the body, and interacts with hormonal, nervous, immune, endocrine, microbiome, and other systems of the body. The eCBome plays a major role in the health and disease of many organs of the body including; the reproductive system in both males and females, hormonal system, kidneys, liver, gut microbiome, heart and circulatory system, nervous system, skin among other tissues.