In the late 1960’s researchers discovered a naturally produced “factor” that would relax the blood vessels. They named it endothelium derived relaxing factor (EDRF). After considerable research, it was later discovered that EDRF was a simple molecule containing one atom of nitrogen and one atom of oxygen produced locally by the blood vessels, and was more correctly called nitric oxide (NO). This discovery eventually culminated in three researchers winning the Nobel Prize for medicine in 1998; sadly one of the key researchers, Salvador Moncada, was overlooked by the Nobel Committee. Who says there are no politics in science?Cardiovascular Disease (CVD),
There is considerable research in natural products and the prevention and reversal of Alzheimer’s Disease (AD). Curcumin, the active component of the spice turmeric, which is widely used in Asian cuisine has come under close scrutiny for its protective effects in various animal models.
Longvida®, a novel form of curcumin is over 100 fold more bioavailable than regular curcumin making it the most bioavailable form of curcumin on the market. Developed by two neuroscientists, Drs. Sally Frautschy and Greg Cole at UCLA, there is increasing animal data that supports the effectiveness of this special solid lipid particle (SLP) formulation of curcumin. Unlike some of the other bioavailable forms on the market, Longvida® actually measures the free form of curcumin in the blood and at the site of action e.g. the joints, heart, cancer cell and the nerve cells, rather than the metabolised forms that other curcumin formulations deliver. Frautschy and Cole studied over two hundred formulations of curcumin before deciding on the Longvida® form as the most effective formulation.
AD is thought to be due in part to either the accumulation in the brain of protein tangles or the plaque, which not only disrupt the transmission of nerve signals but also end up “choking” the nerve cells. More recent research indicates the culprit to be small protein pieces of the tangles and plaque that are soluble and thus harder to detect, as being the most toxic to the nerve cells. In 2011, researchers from Germany reported that 90% of young-adults under the age of 30 had these protein pieces in the brain!
In the December 2012 issue of the prestigious Journal of Biological Chemistry, the UCLA scientists reported that Longvida® form of curcumin was able to fully restore the memory and other cognitive function of the mice compared to the untreated mice. This report is exciting in that the mechanism of action is more fully explained than previous studies. This finding supports last year’s human study by University of Ohio that reported that a very low daily dose (80mg of Longvida®) could significantly reduce the plaque levels in blood of health, middle-aged adults.
The Longvida® form of curcumin is available world-wide in several different formulations from AOR including Curcumin-Active for inflammatory conditions, Curcu Viva (80mg) as used in the Ohio State University study for
cognitive support and CurcuMind which includes curcumin plus vitamin D, another essential nutrient for brain function.
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Begum A Drs. Sally Frautschy and Greg Cole at UCLA N et-al “Curcumin structure and function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease” Journal of Pharmacol Exp Ther 2008: 326; 196-208
Gota V S et-al “Safety and pharmacokinetics of a curcumin solid lipid particle formulation in osteosarcoma and healthy patients” J Agric. Food Chem. 2010: 58; 2095-2099
Ma Q L et-al “Curcumin supresses soluble tau dimers and corrects molecular chaperone, synaptic and behavioural deficits in aged human tau transgenic mice” J of Biol. Chem. 2012 pre-published.
DiSilvestro R A et-al “Diverse effects of a low dose supplement of lapidated curcumin in healthy middle aged people” Nutrition Journal 2012: 11;79-86