A meta-analysis by Paladini et al. published in 2016 evaluated the safety and efficacy of micronized and ultra-micronized PEA. Authors confirmed that it produced analgesia in patients with chronic or neuropathic pain in a manner that was independent of age and gender. Twelve studies were included (3 were double-blind trials, 2 were open-label trials vs standard therapies, and 7 were open-label trials without comparators.) The authors concluded that PEA elicits a progressive reduction of pain intensity significantly higher than control- the magnitude of reduction is 1.04 points (vs 0.2 points in placebo) every 2 weeks (35% response variance.) Making it an effective option for neuropathic pain management. <\/p>
References:<\/strong><\/p> Paladini A, Fusco M, Cenacchi T, Schievano C, Piroli A, Varrassi G. Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis. Pain Physician. 2016;19(2):11-24. <\/p>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"research-category":[192,288,272,275,295,273,292,283,276],"class_list":["post-7370","research-library","type-research-library","status-publish","hentry","research-category-all-research","research-category-cardiovascular","research-category-cognitive","research-category-health-conditions","research-category-immune","research-category-nervous-system","research-category-pain-and-inflammation","research-category-rct","research-category-study-type"],"acf":[],"_links":{"self":[{"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/research-library\/7370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/research-library"}],"about":[{"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/types\/research-library"}],"version-history":[{"count":0,"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/research-library\/7370\/revisions"}],"wp:attachment":[{"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/media?parent=7370"}],"wp:term":[{"taxonomy":"research-category","embeddable":true,"href":"https:\/\/aor.ca\/fr\/wp-json\/wp\/v2\/research-category?post=7370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}