Benfotiamine, Vitamin B1
Benfotiamine is synthetic thioester form of thiamin (vitamin B1) developed in Japan in the 1950’s. It has been shown to be five times more absorbable than regular thiamin and has better penetration through cellular membranes. The benefit of benfotiamine centers around its ability to block a harmful process in the body called protein glycation, which creates Advanced Glycation End-products (AGEs), a role that is not shared by thiamin.
AGEs are formed when cells are exposed to consistently elevated levels of blood sugar. They can lead to significant tissue and DNA damage, speed up the aging process, and ultimately lead to diabetic-related nerve damage in the hands and feet and damage to blood vessels in the eyes and kidneys. Benfotiamine has the unique ability to block the formation of AGEs and supplementation can help reduce nerve pain and improve nerve function. Many randomized, double-blind, placebo-controlled human trials have proven that benfotiamine powerfully supports nerve function in diabetic neuropathy.
Technical insights:
- Country of origin: China
- Benfotiamine contains a negatively charged phosphate group, making it practically insoluble in organic solvents and exists only as the Z isomer
- It was previously thought that this thioester was lipophilic though this has since been disproven. Superior stability and absorption can be attributed to its ability to rapidly break down as it passes through the small intestine and the breakdown product is lipophilic. Meaning this form has a relatively long half-life and accumulation ratio.
- Stored form: White crystalline powder
Non_GMO
Ingredient Benefits
Clears Advanced Glycation End-products (AGEs)
Benfotiamine, with greater bioavailability than thiamine, activates an enzyme that helps clear advanced glycation end-products (AGEs) that can damage the lining of the heart and blood vessels and the lens of the eyes. Thus, improving blood clotting regulation, assisting the body's immune response, and the ability to better control fluids and electrolytes in the tissues.
Protects against negative effects of high blood sugar such as accelerated cellular aging and nerve damage
It has been found to provide a higher bioavailability of thiamine than its water-soluble version. Benfotiamine reduces advanced glycation end-products (AGE) by 40%, which has been shown to prevent effects on nerves and cells due to high blood sugar in individuals with type 2 diabetes. Benfotiamine has been the most studied for diabetic neuropathy. At therapeutic doses it improves the body's response to pain by the somatic (sensory) nervous system (SNS). Benfotiamine is involved in producing the enzymes that are attributed to its pain-relieving effect.
Neuroprotective benefits for cognitive disorders
Emerging research suggests that along with blood glucose regulation, the antioxidant and AGE’s reduction mechanism of action of benfotiamine can be applied to cognitive and neurodegenerative diseases.
Did you know that AOR participates in research collaborations at prestigious universities across the world? In fact, AOR has supplied finished capsules of benfotiamine for two clinical trials.
Products with this ingredients
Research on this Ingredient
Let’s keep in touch
Don’t worry we only send updates monthly on offers, product changes, and new opportunities for you.
"*" indicates required fields