Indole-3-carbinol (I-3-C) is a phytonutrient found in Brassica vegetables such as broccoli, kale and cabbage, and is one of the key health-promoting compounds in these foods. I3C needs stomach acid to then convert into 15+ compounds, of which the most predominant is DIM. DIM facilitates the production of the protective 2-hydroxy-estrogen (2OHE) metabolites through induction of phase I CYP1A1 enzymes, accounting for many of its benefits. Many studies have had phenomenal success using I-3-C to shift the balance of metabolic enzymes that process estrogens thereby reducing the formation of “bad” estrogens and increasing the formation of “good” estrogens.
Human studies in women taking I-3-C have shown a favourable shift in estrogen metabolism, and I-3-C has been shown to be protective against estrogen dominance. Estrogen dominance has been linked to fibroids, breast tenderness, premenstrual syndrome, endometriosis and other women’s health concerns.
- Country of origin: China
- Starting material: Pharmaceutically synthesized
- Stored form: Off white to white crystalline powder