Since 1998, when the Nobel Prize in medicine was awarded for the work on nitric oxide (NO) as a signalling molecule that was responsible for dilation of the blood vessels, research in NO has accelerated rapidly. In the mid 1990’s two independent research teams from University of London and the Karolinska Institute in Sweden found that NO could be generated from nitrates that were abundant in green leafy vegetables like spinach, lettuce, kale and especially beetroot. This requires the activation of the NOx 3,2,1 pathway to be fully operational. In effect, nitrates consumed in foods are reduced by oral bacteria
We have established that to some extent, most people are deficient in magnesium, and that food sources usually do not have a high enough magnesium content to exert a rapid change of levels in the body. This means there is a pivotal need for high quality and effective magnesium supplementation. Unlike other natural substances, magnesium supplements come in many different forms, each with their own strengths and weaknesses. Let’s explore the differences in forms so that you can identify which one is best for you.
Both in nature and in supplements, minerals such as magnesium, zinc, and calcium must be combined with another molecule to form a compound. This occurs because of the basic laws of chemistry. A mineral like magnesium has a positive charge and will attract another molecule with a negative charge, forming a combination called a compound. Supplementing with just elemental magnesium (Mg2+) is not possible.
Each magnesium compound has a different level of absorption, bioavailability, and therapeutic value. These additional molecules often impact the medicinal value of the magnesium, and also have some benefits on their own (eg. the amino acid glycine).
Useful as a laxative
Poor oral bioavailability
Poor bowel tolerance
Not bound to an amino acid
Least optimal as a suppement
Moderate magnesium yield
Good bowel tolerance
Table 4: Magnesium Types