CardioNOx

AOR14001

Supports healthy cardiovascular function

  • Coenzyme Q10 supercharged with nitric oxide
  • Promotes healthy blood pressure and oxygenation
  • Reduces stress on the heart
  • Maximum effectiveness at a lower dose
Gluten Free
Non-GMO
Vegan

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When it comes to cardiovascular health, one of the most important tissues of body is the inner lining of our blood vessels (called the endothelium). It regulates blood flow, the delivery of nutrients to organs and tissues and removal of wastes, but unfortunately it is also very sensitive to inflammation and oxidative damage. Nitric oxide is the key molecule that regulates and protects the endothelium, and thus the body has developed an elegant way to maintain a steady supply of it by converting it from nitrates found in numerous vegetables like beetroot, spinach and arugula. AOR’s NOx family of products are designed to enhance the production of nitric oxide in combination with well-studied nutrients. CardioNOx contains Coenzyme Q10 and potassium nitrate, a precursor to nitric oxide, both of which are highly important nutrients for cardiovascular support.

CoQ10 is a powerful antioxidant that protects the mitochondria from free radical damage and supports energy production. Energy-producing mitochondria are found in abundance in the heart because the heart requires massive amounts of energy to function properly. Both CoQ10 and supplemental Nitric Oxide have been found to lower blood pressure, since both support healthy function and dilation of blood vessel cells. The combination of CoQ10 and Nitric Oxide creates an excellent heart health and anti-aging formula.

AOR Advantage

AOR was the first in the world to capitalize on the direct conversion of nitrate and nitrite to nitric oxide within the body. Cardio NOx not only delivers the combined benefits of CoQ10 and Nitric Oxide, it is also convenient to take as the effective dose is just one capsule per day. Those concerned with aging, cardiovascular health, blood pressure support, and those desiring greater energy production will benefit from CardioNOx.

 

 

 

NPN

02159589

Discussion

Contains coenzyme Q10, an essential factor in the production of cellular energy in the mitochondria and a powerful fat-soluble antioxidant. Extensive research demonstrates that CoQ10 supports healthy cardiovascular function. Nitric Oxide helps blood vessels to open wider for improved blood flow and circulation.

Guarantee

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule one to three time daily with a fat containing meal, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you’re taking blood pressure medication, if you’re taking blood thinners, if you have an iron deficiency, if you have a liver disorder or for use beyond 12 weeks. If you develop symptom such as a troubled liver (yellowing of the skin or eyes [jaundice]), stomach pain, dark urine, sweating, nausea, unusual tiredness and/or loss of appetite, discontinue use and consult a health care practitioner. Rare unpredictable cases of liver injury associated with green tea extract-containing products have been reported (in Canada/Internationally).

Main Applications
  • Cardiovascular health
  • Healthy blood pressure
  • Mitochondrial function
  • Energy/Fatigue
  • Aging
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule

Non-medicinal Ingredients: potassium nitrate (providing 259 mg nitrate), green tea extract, citric acid and microcrystalline cellulose. Capsule : hypromellose.

Cardiovascular Effects

Study #1:

In a clinical trial of 109 patients with essential hypertension, patients were individually given CoQ10. Doses varied until blood levels reached >2 mcg/mL. The functional status of hypertensive patients improved with the need to gradually decrease any antihypertensive pharmaceutical treatment the patient was previously taking within one to six months of CoQ10 supplementation. 51% of patients were completely taken off their antihypertensive drugs by about four months of CoQ10 use. Patients also showed significantly improved blood pressure measurements (both systolic and diastolic) and New York Heart Association (NYHA) functional class status (p<0.001). Echocardiograms before and during treatment showed significant improvements in left ventricular wall thickness and diastolic function after CoQ10 supplementation.

Langsjoen P, Langsjoen P, Willis R and Folkers K. (1994). Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 15; Suppl: S265-72

Study #2:

In this study, 26 patients with essential arterial hypertension were treated with 100 mg CoQ10 for 10 weeks. At the end of the treatment period, systolic and diastolic blood pressures significantly decreased by 17 mmHg and 12 mmHg, respectively (P<0.0001). Serum total cholesterol significantly decreased and serum HDL cholesterol was significantly increased after treatment as well.

Digiesi V, Cantini F, Oradei A, et al. (1994). Coenzyme Q10 in essential hypertension. Mol Aspects Med. 15 Suppl: s257-63

Study #3:

In a European sub-population of the Q-SYMBIO trials, patients with moderate to severe heart failure were randomized in this double-blind trial to 300 mg of CoQ10 daily. Study end-points were monitored at three months and two years. The group treated with CoQ10 had significant improvements in all-cause and cardiovascular mortality, NYHA classification and left ventricular ejection fraction, compared to placebo.

Mortensen AL, Rosenfeldt F, Filipiak KJ. (2019). Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial. Cardiol J. 26(2): 147-56

Study #4:

In a randomized, crossover study, supplementation with potassium nitrate (1488 mg of nitrate) led to decreases in blood pressure of healthy adults, and more so in men with higher baseline blood pressure measurements.

Kapil V, Milsom AB, Okorie M, et al. (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 56(2): 274-81

Study #5:

In a double-blind, placebo-controlled, randomized trial, 68 patients with hypertension were given either dietary nitrate as 250 mL beetroot juice, or placebo (nitrate-free beetroot juice) for two weeks. Supplementation with nitrate beetroot juice led to significant reductions in mean blood pressure (7.7/2.4 mmHg), 24-hour ambulatory blood pressure (7.7/5.2 mmHg) and home blood pressure by 8.1/3.8 mmHg. Additionally, after nitrate treatment the patients’ endothelial function improved by about 20% and arterial stiffness decreased significantly (0.24-0.93 m/s). No changes were seen in the placebo group.

Kapil V, Khambata RS, Robertson A, et al. (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 65(2): 320-7

Study #6:

In a double-blind, placebo-controlled parallel trial 67 patients with serum cholesterol levels >6.0 mmol/L or any elevation in LDL cholesterol or triglycerides with a cardiovascular disease risk score >15% (National Health Service). Patients were randomized to receive 250 mL beetroot juice (nitrate supplement) or a placebo, nitrate-free beetroot juice for six weeks. After the treatment period the group given the nitrate-containing juice had an increase in flow-mediated dilation (FMD), a marker of vascular function, with an improvement of about 24% from baseline; meanwhile FMD in the placebo group worsened. Other changes noticed with nitrate supplementation include improvements in aortic pulse wave velocity and a significant reduction (7.6%) in platelet-monocyte aggregates while that of the placebo group increased by 10.1%.

Velmurugan S, Gan JM, Rathod KS, et al. (2016). Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr. 103(1): 25-38

 

Fatigue and Pain in Fibromyalgia

Study #1:

Plasma levels of ubiquinol-10 has been found to be significantly lower in patients with juvenile fibromyalgia compared to healthy controls. In a study, 10 patients with juvenile fibromyalgia were given 100 mg of CoQ10 daily for 12 weeks, then placebo for eight weeks, and then 100 mg of CoQ10 again for another eight weeks.  Subjective pain intensity did not change with CoQ10 supplementation, but symptoms of chronic fatigue (measured via the Chalder Fatigue Scale) significantly improved.

Miyamae T, Seki M, Naga T, et al. (2013). Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation. Redox Rep. 18(1): 12-9

Study #2:

In a study of twenty patients with fibromyalgia and fifteen healthy controls, ten patients volunteered to supplement with 300 mg daily of CoQ10 for three months. At baseline, CoQ10 and catalase levels were significantly lower in patients with fibromyalgia, and markers of oxidative stress were increased, compared to control subjects. Researchers also found a significant negative correlation between CoQ10 and catalase levels and Headache Impact Test (HIT-6) scores. There was also a significant positive correlation between oxidative stress markers and HIT-6 scores. Patients given CoQ10 had significant improvements in HIT-6 scores, Visual Analogue Scale score, and Fibromyalgia Impact Questionnaire scores. Findings were statistically significant from pre- and post-treatment, and with respect to controls.

Cordero MD, Cano-Garcia FJ, Alcocer-Gomez E, et al. (2012). Oxidative stress correlates with headache symptoms in Fibromyalgia: Coenzyme Q10 effect on clinical improvement. PLoS One. 7(4): e35677

Study #3:

In a case series of five patients with fibromyalgia, patients were given 300 mg of CoQ10 daily for nine months. Patients had a significant reduction in symptoms as measured on the Visual Analogue Scale and Fibromyalgia Impact Questionnaire.

Cordero MD, Alcocer-Gomez E, de Miguel M. (2011). Coenzyme Q(10): a novel therapeutic approach for fibromyalgia? Case series with 5 patients. Mitochondrion. 11(4): 623-5