Melatonin DualCap

AOR04446

Supports sleep throughout the night

  • Sleep aid with sustained release
  • Helps to reduce/speed up time it takes to fall asleep
  • Melatonin lasts through the night
  • Helps to reduce the effects of jet lag
Gluten Free
Non-GMO

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Working in concert with your body’s circadian rhythm, melatonin is a hormone the body creates that tells you when it is time for bed and it is also an antioxidant used by the body.  Many people are affected by poor sleep or a lack of sleep. This can lead to complications for the body, from depleting energy, to lowering productivity and affecting diet and exercise routines. Melatonin can also help with jet lag, which affects the body’s internal clock by being in a new time zone.

AOR ADVANTAGE

AOR’s Melatonin DualCap provides both an immediate and a delayed dose of melatonin for a restful sleep that lasts through the night.

NPN

80097961

Discussion

Helps increase the total sleep time (aspect of sleep quality) in people suffering from sleep restriction or altered sleep schedule (e.g. shift-work and jet lag). Helps to prevent and/or reduce the effects of jet lag/minimize jet lag (e.g. daytime fatigue, sleep disturbance) (for people travelling by plane easterly across two or more time zones/if flying east over two or more time zones). Helps to speed up/reduce the time it takes to fall asleep (sleep onset latency aspect of sleep quality) in people who fall asleep slowly/with delayed sleep phase disorder. Helps to reset the body’s sleep-wake cycle (aspect of the circadian rhythm).

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, eggs, fish or shellfish.

Adult Dosage

Take one capsule, before bedtime; or as directed by a health care practitioner. If taking for jetlag, take one capsule once a day at bedtime, while travelling, and at a destination until adapted to the new time zone / or daily pattern; or as directed by a health care practitioner. Do not open capsules, as this may compromise the stability of the medicinal ingredients.

Caution

Consult a health care practitioner for use beyond four weeks. Avoid taking with alcohol or products that cause drowsiness. Consult a health care prior to use if you are taking medications for seizure, blood pressure, to suppress the immune system (immunosuppressive medications), to affect mental state or increase sedation, steroids or blood thinners. Consult a health care practitioner prior to use if you have cardiovascular, immune, liver or chronic kidney disease, hormonal or seizure disorders, asthma, depression, diabetes, low blood sugar or migraine. Do not use this product if you are pregnant or breastfeeding. Do not drive or use machinery for five hours after taking melatonin. Stop use if allergy occurs or if you experience headache, confusion or nausea.

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: 1 Duo-Capsule
Inner capsule
2 mg
Outer capsule
3.15 mg

Non-medicinal ingredients: Glycerin.

Capsule: hypromellose, carrot root powder

Therapeutic Effects of Melatonin

Ingestion of melatonin induces fatigue, sleepiness, and a diminution of sleep latency. Therapeutic effects of melatonin have also been reported in several disorders such as certain tumors, cardiovascular diseases, or psychiatric disorders. Melatonin plays a major role in the regularity and synchronization of central and peripheral oscillators allowing the development of harmonious internal functioning and adaptation of the internal environment to external environment.

Tordjman S, Chokron S, Delorme R, et al. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017;15(3):434-443. doi:10.2174/1570159X14666161228122115 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/

Treatment for Sleep Disorders

Study #1:

 This randomised, placebo-controlled, double-blind clinical trial tested the efficacy of 0.5 mg melatonin, combined with behavioural sleep-wake scheduling, for improving sleep initiation in 116 clinically diagnosed DSWPD patients with a delayed endogenous melatonin rhythm relative to patient-desired (or -required) bedtime (DBT).

Following a one week baseline, clinically diagnosed DSWPD patients with delayed melatonin rhythm relative to DBT were randomised to four week treatment with 0.5 mg fast-release melatonin or placebo one hour before DBT for at least five consecutive nights per week. All patients received behavioural sleep-wake scheduling, consisting of bedtime scheduled at DBT. Relative to baseline and compared to placebo, sleep onset occurred 34 min earlier (95% confidence interval [CI] -60 to -8) in the melatonin group. SE T1 increased; PROMIS sleep-related impairment, PROMIS sleep disturbance, insomnia severity, and functional disability decreased; and a greater proportion of patients showed more than minimal clinician-rated improvement following melatonin treatment (52.8%) compared to placebo (24.0%) (P < 0.05). Improvements were achieved largely through the sleep-promoting effects of melatonin, combined with behavioural sleep-wake scheduling.

Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini SM, Bartlett DJ, Lockley SW, Lack LC, Grunstein RR, Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial. PLoS Med. 2018 Jun 18;15(6):e1002587. doi: 10.1371/journal.pmed.1002587. PMID: 29912983; PMCID: PMC6005466. https://pubmed.ncbi.nlm.nih.gov/29912983/

Study #2:

 This 2016, narrative review aims to provide a comprehensive overview of various therapeutic functions of melatonin in insomnia, sleep-related breathing disorders, hypersomnolence, circadian rhythm sleep–wake disorders and parasomnias. Melatonin was found to offer an alternative treatment to the currently available pharmaceutical therapies for sleep disorders with significantly less side effects.

Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Neurol Res. 2017 Jun;39(6):559-565. doi: 10.1080/01616412.2017.1315864. Epub 2017 May 1. PMID: 28460563. https://pubmed.ncbi.nlm.nih.gov/28460563/

Study #3:

Several recently published meta-analyses have shown that there is evidence for the efficacy of exogenously administered melatonin in a number of sleep disorders. However, melatonin is likely to be prescribed largely for reasons of perceived minimal side-effect profile and very low cost in situations in which high-quality evidence for its usefulness is not forthcoming. There is evidence for the efficacy of melatonin in the management of insomnia and some intrinsic disorders of circadian rhythm in adults and children as well as in reducing sleep onset latency in jetlag and shift work disorder in adults. Melatonin is used routinely in the treatment of rapid-eye movement sleep-behaviour disorder despite limited trial evidence.

Riha RL. The use and misuse of exogenous melatonin in the treatment of sleep disorders. Curr Opin Pulm Med. 2018 Nov;24(6):543-548. PMID: 30148726 https://pubmed.ncbi.nlm.nih.gov/30148726/

Treatment for Jetlag

Meta-analysis of data from four studies (232 participants) showed that jet lag severity (assessed using a 100-point scale) was 27 with melatonin and 45 with placebo. Drowsiness and sleepiness, headache, dizziness, and disorientation are the most frequently reported adverse effects with melatonin.

Melatonin for jet lag. Drug Ther Bull. 2020 Feb;58(2):21-24. doi: 10.1136/dtb.2019.000074. Epub 2020 Jan 13. PMID: 31932335. https://pubmed.ncbi.nlm.nih.gov/31932335/

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