MSM + Glucosamine a été spécialement conçu pour réduire la douleur et l’enflure, et pour améliorer le fonctionnement des articulations chez les personnes souffrant d’arthrose. Le MSM ou méthylsulfonylméthane est une forme naturelle du soufre organique présente dans les organismes vivants. Chez l’homme, le soufre est présent dans tout l’organisme, dans plusieurs composés organiques et intervient dans divers processus au sein de l’organisme. La glucosamine est composée de glucose et de glutamine, un acide aminé. Le sulfate de glucosamine est naturellement présent dans le cartilage articulaire et le liquide synovial, et l’organisme a besoin de sulfate pour la production du tissu cartilagineux. Le MSM et le sulfate de glucosamine semblent produire de meilleur résultats pour le soulagement de la douleur liée à l’arthrose lorsqu’ils sont utilisés en combinaison que lorsqu’ils sont utilisés séparément.

La capacité du MSM à réduire la douleur au genou et à améliorer la fonction physique en cas d’arthrose est due à ses activités anti-inflammatoires et de soutien du tissu conjonctif. La glucosamine aide le corps à créer des fluides et tissus amortissants autour des articulations. Elle répare également les articulations endommagées par l’arthrose, réduit la douleur et favorise la production du liquide synovial.

MSM + Glucosamine est un complément idéal pour des personnes qui sont à la recherche d’un soulagement de l’arthrose ou des douleurs et inflammations articulaires. MSM + Glucosamine d’AOR a l’avantage supplémentaire d’être une formule de glucosamine végétarienne, sans crustacés, ce qui le rend convenable aux végétaliens et personnes allergiques aux coquillages.

Avantage AOR

L’association MSM-glucosamine est plus efficace pour l’amélioration de la douleur, l’enflure, la mobilité articulaire et l’inflammation. MSM + Glucosamine d’AOR fournit cette combinaison efficace à des doses cliniquement testées. Le sulfate de glucosamine est désormais obtenu à partir d’une source végétarienne sans mollusque, ce qui fait de MSM + Glucosamine d’AOR un produit 100 % végétarien.

Background

MSMAlso known as methyl sulfone, methylsulfonylmethane, or dimethylsulfone (DMSO2), is an organic, odorless, naturally-occurring sulfur compound present in small amounts in many foods and beverages. MSM as a supplement is useful for ameliorating upset stomachs, improving people’s resistance to allergies, reducing pain from inflammatory disorders, and helping the body rid itself of parasites. In the last decade, however, MSM has carved out a particular niche for itself as an effective adjunct to any formulation pertinent to the maintenance of healthy joint structure and function.Glucosamine: What is it?Glucosamine is arguably the best-studied of all joint-support supplements, serving the needs of both young and old, athletic and arthritic or injured. Glucosamine is an amino sugar used to create cushioning fluids and tissues around joints. It also repairs damaged arthritic joints, reduces pain, and builds synovial fluids. It is easily absorbed into the bloodstream, and is necessary in the formation of skin, eyes, bones, tendons, nails, ligaments, and parts of the heart.How does Glucosamine work?Glucosamine is also referred to as an aminomonosaccharide, meaning that it is the product of the synthesis between glucose and an amino acid -in this case glutamine. This enzymatic process is called glucosamine synthetase. Most glucose and nearly half of all amino acids are obtained through dietary sources, but the aminomonosaccharides found in our bodies are formed internally, and dietary sources for them are negligible. Glucosamine is produced naturally in the body by chondrocytes in cartilage to help maintain and build healthy joint tissue. The main basic purpose of glucosamine is to create long chains of modified disaccharides called glycosaminoglycans (GAGs), which the joints and cartilage require for repair. The GAGs are the main component of proteoglycans (PGs), which along with chondrocytes and collagen, make up cartilage. Glucosamine is also converted in the body to N-acetyl-glucosamine, which in turn is critical to the formation of hyaluronic acid. Hyaluronic acid is the central component of synovial fluid which acts as a lubricant in the joints.SulfurPeople don’t generally think of sulfur as an essential nutrient, but nonetheless sulfur is required for human nutrition and health.Organic sulfur is readily found in living organisms, such as human tissues, milk, fruits, and vegetables. However, it can be easily destroyed by perfectly normal handling of food, like cooking, heating, processing, or drying. And while sulfur is naturally found in most organisms, its fragility combined with modern cooking practices places our daily intake of sulfur into an increasingly precarious position.What does sulfur do then? It holds our basic connective tissues together, forming the elemental structure of proteins, and is required for a number of catalytic functions of various enzymes (meaning that without sulfur these enzymes cannot even start their essential activity).In humans, sulfur is present throughout the body in several organic compounds and is a factor in a number of different processes in the body. It is used to produce such vital substances as amino acids, including taurine (which stabilizes cell membranes), and methionine (which detoxifies cells and is involved in pain relief).Helping the Joints via Anti-inflammatory/Anti-oxidant PathwaysInflammatory disorders, such as arthritis, can cause persistent and sometimes debilitating pain. MSM has been shown to significantly relieve the pain and inflammation caused by inflammatory disorders. It has been shown to significantly reduce nighttime leg cramps, back cramps, and muscle spasms. Sulfur is concentrated in or around osseous (bone or turning to bone) structures and sulfur supplementation supports healthy muscles, tendons, and ligaments. The mechanism for MSM’s anti-inflammatory action appears to be intrinsically related to it’s concurrent role as an anti-oxidant against the specific free radicals of hydrogen peroxide, superoxide, and hypochlorous acid. These free radicals play an initiatory role in the inflammation process that is the underlying cause of so many maladies related to the joints.Other UsesMSM has also been used for a number of other ailments and to support a number of other systems in the body. Like digestive enzymes, it allows the body to absorb more nutrients from food. It also helps circulation, hair and nail growth, as well as the healing process itself. MSM also causes the body to secrete more taurine (an amino acid that is vital to cardiovascular activity) in tissues. Furthermore, MSM neutralizes the toxicity of a chemical called anticholinesterase, which is contained in many insecticides. MSM also reduces the lactic acid buildup that occurs after strenuous exercise. Lactic acid buildup occurs as muscles are exercised, but endurance training reduces lactic acid buildup, much as MSM does.

Research

Tissue RepairIn the treatment of inflammatory joint diseases, the research conducted with glucosamine sulfate is extensive. With respect to osteoarthritis alone, there have been 20 randomized controlled trials involving a total of 2570 patients. The collective results displayed a 28% (change from baseline) improvement in pain and a 21% (change from baseline) improvement in function for those patients supplementing with glucosamine over the control (placebo) groups.When used in combination, methylsulfonylmethane and glucosamine seem to produce superior results than when they are used separately. An example of this synergy has been clearly demonstrated in another study of osteoarthritis, this one examining the benefits of MSM and glucosamine both separately and in combination. It was concluded that in areas such as pain reduction, swelling, joint mobility, as well as analgesic and anti-inflammatory activity, that MSM and glucosamine sulfate worked more rapidly and more effectively together than they did separately.

Market Trends

Joint support is a relatively new niche in the world of alternative medicine, composed mainly of SAMe (s-adenosylmethionine), hyaluronic acid, shark cartilage, methylsulfonylmethane (MSM), chondroitin sulfate, and glucosamine sulfate. Of these, methylsulfonylmethane (MSM) and glucosamine sulfate have emerged as two of the most widely accepted substances for maintaining healthy joint structure and flexibility.

AOR Advantage

MSM and glucosamine in combination are more effective for improving pain, swelling, joint mobility, and inflammation. AOR’s MSM Glucosamine provide this effective pairing in clinically tested doses. The glucosamine sulfate source is now a vegetarian shellfish-free source, making AOR’s MSM Glucosamine 100% vegetarian.

References

Baker CL, Ferguson CM. “Future treatment of osteoarthritis.” Orthopedics. 2005 Feb;28(2 Suppl):s227-34.Dechant JE, Baxter GM, Frisbie DD, Trotter GW, McIlwraith CW. “Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism.” Equine Vet J. 2005 May;37(3):227-31.Herschler JS. “Introductory remarks: Dimethylsulfoxide after twenty years.” Ann. NY Acad. Sci. 441, xiii-xvii (1983).Simanek V, Kren V, Ulrichova J, Gallo J. “The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: Are these saccharides drugs or nutraceuticals?” Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jul;149(1):51-6.Towheed TE, Maxwell L, Anastassiadies TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. “Glucosamine therapy for treating osteoarthritis.” Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002946.Usha PR, Naidu MUR. “Randomized, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.” Clin Drug Invest 2004;24(6):353-363.

Abstract

Future treatment of osteoarthritis.Orthopedics. 2005 Feb;28(2 Suppl):s227-34.Baker CL Jr, Ferguson CM.Osteoarthritis represents an advanced stage of disease progression caused in part by injury, loss of cartilage structure and function, and an imbalance in inflammatory and noninflammatory pathways. The burden of this disease will increase in direct proportion to the increase in the older adult population. Research on current and experimental treatment protocols are reviewed, including the effect of hyaluronic acid in both in vitro and in vivo studies, autologous chondrocyte and osteochondral plug implantation, and gene therapy. Disease-modifying osteoarthritis drugs and in vivo studies of glucosamine and chondroitin sulfate are reviewed. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.Clin Drug Investig. 2004;24(6):353-63.Usha PR, Naidu MU.OBJECTIVE: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.PATIENTS AND DESIGN: A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks. Patients were evaluated at 0 (before drug administration), 2, 4, 8 and 12 weeks post-treatment for efficacy and safety. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine.RESULTS: Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. There was a statistically significant decrease in mean ( /- SD) pain index from 1.74 /- 0.47 at baseline to 0.65 /- 0.71 at week 12 with Glu (p < 0.001). MSM significantly decreased the mean pain index from 1.53 /- 0.51 to 0.74 /- 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 /- 0.47 to 0.36 /- 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 /- 0.63 to 0.14 /- 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated.CONCLUSION: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.