Niacine Sans Rougeur

AOR04033

Vitamine B3 (sans rougeur)

  • Sa libération lente réduit considérablement la « rougeur » caractéristique de la niacine
  • Plus sûre pour le foie que les produits « sans rougeur » courants
  • Soutient la santé des nerfs, la digestion et la production d’énergie
Sans Gluten
Sans OGM
Végétalien

$35.56

En stock

La niacine est un nutriment essentiel également connu sous l’appellation de vitamine B3. On la retrouve dans des aliments comme les légumes, les noix, les avocats, les œufs, la viande et les produits laitiers. La niacine est hydrosoluble et n’est pas stockée dans l’organisme, ce qui signifie qu’il est important d’en consommer suffisamment à travers l’alimentation et les suppléments.

La niacine aide au bon fonctionnement des nerfs, de la peau et du système digestif. C’est un facteur important dans la conversion des aliments en énergie et est nécessaire dans de nombreuses fonctions biologiques vitales, notamment la production d’énergie cellulaire et la réparation de l’ADN. Bien que la niacine les effets de la soient bénéfiques, elle provoque souvent un symptôme désagréable de « rougissement » caractérisé par une sensation inoffensive, mais inconfortable de réchauffement et de démangeaison de la peau. La niacinamide, un type courant de niacine à libération prolongée, ne cause pas cet effet de rougissement, mais s’accompagne d’un effet secondaire encore pire, soit un éventuel endommagement du foie.

Niacine Sans Rougeur d’AOR fournit une forme unique de niacine connue sous le nom d’hexanicotinate d’inositol (IHN), un composé qui libère lentement la vitamine B3 dans le corps pour prévenir l’effet de bouffées de chaleur, mais sans les risques potentiels pour le foie associés à la prise de la niacinamide. Niacine Sans rougeur est un excellent moyen d’augmenter votre consommation de niacine sans les effets indésirables de rougissement.

Avantage AOR

Niacine Sans Rougeur d’AOR contient de l’hexanicotinate d’inositol, une forme de niacine liée à l’inositol. Cette liaison lui permet de libérer la niacine dans la circulation sanguine de façon lente et contrôlée, évitant à la fois l’inconfort occasionné par le rougissement et le danger que représente l’endommagement du foie.

NPN

80015111

Discussion

La vitamine B3 ou niacine peut produire des effets secondaires désagréables comme des démangeaisons et une sensation de brûlure : “des rougeurs”. L’hexanicotinate d’inositol, un esther de la vitamine B3 ne produit pas ces effets secondaires désagréables.

Certifie

AOR™ certifie que tous les ingrédients sont mentionnés sur l’étiquette. Ne contient ni blé, ni gluten, ni noix, ni arachide, ni graine de sésame, ni sulfite, ni moutarde, ni soja, ni produit laitier, ni œuf, ni poisson, ni mollusque, ni crustacé ou produit d’origine animale.

Posologie Adulte

Prendre une capsule par jour avec ou sans nourriture, ou selon les recommandations d’un professionnel de la santé. Ne pas dépasser la dose recommandée, sauf sur avis d’un médecin.

Mises en Garde

Aucun effet indésirable grave lié à la consommation de l’hexanicotinate d’inositol n’a été signalé. Toutefois, des cas de réactions de ce type ont été signalées pour la niacine conventionnelle, qui ne peut être totalement exclut pour l’instant. Il est recommandé que des analyses régulières des enzymes hépatiques soient effectuées en consultation avec un médecin.

Main Applications
  • General health
  • Cardiovascular health
Avertissement

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Portion: une capsule
Hexanicotinate d’inositol
550 mg
– Niacine (vitamine B3)
500 mg
– Inositol
121 mg

Ingrédients non médicinaux : cellulose microcristalline, stéarylfumarate de sodium.

Background

Background InformationNiacin (nicotinic acid, a form of vitamin B3) is an important cellular mediator. Niacin is metabolized primarily in the liver to niacinamide, which is a precursor to the two cellular coenzymes nicotine-adenine dinucleotide (NAD ) (and its high-energy form, NADH), and nicotine-adenine dinucleotide phosphate (NADP). These coenzymes are responsible for carrying out numerous reduction-oxidation (redox) reactions in the body, including their role in energy production in the mitochondria, and play a vital role in protecting and repairing DNA through the enzyme poly-ADP ribose polymerase (PARP).Different Forms of NiacinThe big problem with high-dose niacin supplementation is the niacin flush. Because it causes blood vessels to expand and release histamines (the immune factors responsible for some of the symptoms of allergies), higher-dose niacin causes warming and itching of the skin. The effect is a harmless – but some people find it absolutely maddening, and stop taking niacin altogether. Early attempts to solve this problem with a simple “sustained-release” niacin formulation called niacinamide eliminated the ‘flush,’ but caused a much more serious one: sustained-release niacin causes liver toxicity in a significant percentage of those taking it. To put this in context: while 39% of patients on regular niacin go off the supplement, mostly because of digestive problems and the “flush,” 78% of those administered regular “sustained-release” niacin quit because of side effects, with 52% of them suffering liver toxicity!By contrast, less than 1% of people supplementing their diets with high doses of regular niacin experience liver problems – a rate several times lower than that of patients taking statin drugs. Still, the potential of liver toxicity rightly gives many people pause.While nicotinamide is sometimes mistakenly referred to as “flush-free niacin,” nicotinamide is actually not niacin at all, but a niacin metabolite, which lacks the ability to carry out some of the most beneficial activities of niacin.Inositol Hexanicotinate (IHN – also sometimes called inositol hexaniacinate) is the true “flushless niacin.” Unlike “sustained-release” niacin, which is just regular niacin in a pill which dissolves more slowly, IHN is a niacin complex, formed with the B-vitamin-like inositol. When you take an IHN supplement, the central inositol ring gradually releases niacin molecules, one at a time – delivering true niacin, but in a controlled fashion governed by the kinetics of the hydrolysis of the molecule itself. This, like “sustained-release” niacin, allows you to take niacin at clinically-proven doses without going crazy with itch – but there is one big difference. While it’s a good idea to have your liver enzymes tested while you’re taking it, the fact is that no clinical trial has ever reported liver toxicity in persons supplementing with “flush-free” niacin. Regular monitoring of people taking doses as high as 4 000 mg of inositol hexanicotinate daily for four-month stretches has revealed no evidence of liver problems, or even changes in liver enzyme readings.While only a few milligrams of niacin are needed each day to prevent a frank, life-threatening deficiency, studies clearly show that higher doses of niacin can be beneficial in some cases.

Research

Niacin (nicotinic acid, a form of vitamin B3) is an important cellular mediator. Niacin is metabolized primarily in the liver to niacinamide, which is a precursor to the two cellular coenzymes nicotine-adenine dinucleotide (NAD ) (and its high-energy form, NADH), and nicotine-adenine dinucleotide phosphate (NADP). These coenzymes are responsible for carrying out numerous reduction-oxidation (redox) reactions in the body, including their role in energy production in the mitochondria, and play a vital role in protecting and repairing DNA through the enzyme poly-ADP ribose polymerase (PARP).Different Forms of NiacinThe big problem with high-dose niacin supplementation is the niacin flush. Because it causes blood vessels to expand and release histamines (the immune factors responsible for some of the symptoms of allergies), higher-dose niacin causes warming and itching of the skin. The effect is a harmless – but some people find it absolutely maddening, and stop taking niacin altogether. Early attempts to solve this problem with a simple “sustained-release” niacin formulation called niacinamide eliminated the ‘flush,’ but caused a much more serious one: sustained-release niacin causes liver toxicity in a significant percentage of those taking it. To put this in context: while 39% of patients on regular niacin go off the supplement, mostly because of digestive problems and the “flush,” 78% of those administered regular “sustained-release” niacin quit because of side effects, with 52% of them suffering liver toxicity!By contrast, less than 1% of people supplementing their diets with high doses of regular niacin experience liver problems – a rate several times lower than that of patients taking statin drugs. Still, the potential of liver toxicity rightly gives many people pause.While nicotinamide is sometimes mistakenly referred to as “flush-free niacin,” nicotinamide is actually not niacin at all, but a niacin metabolite, which lacks the ability to carry out some of the most beneficial activities of niacin.Inositol Hexanicotinate (IHN – also sometimes called inositol hexaniacinate) is the true “flushless niacin.” Unlike “sustained-release” niacin, which is just regular niacin in a pill which dissolves more slowly, IHN is a niacin complex, formed with the B-vitamin-like inositol. When you take an IHN supplement, the central inositol ring gradually releases niacin molecules, one at a time – delivering true niacin, but in a controlled fashion governed by the kinetics of the hydrolysis of the molecule itself. This, like “sustained-release” niacin, allows you to take niacin at clinically-proven doses without going crazy with itch – but there is one big difference. While it’s a good idea to have your liver enzymes tested while you’re taking it, the fact is that no clinical trial has ever reported liver toxicity in persons supplementing with “flush-free” niacin. Regular monitoring of people taking doses as high as 4 000 mg of inositol hexanicotinate daily for four-month stretches has revealed no evidence of liver problems, or even changes in liver enzyme readings.While only a few milligrams of niacin are needed each day to prevent a frank, life-threatening deficiency, studies clearly show that higher doses of niacin can be beneficial in some cases.

AOR Advantage

AOR’s Niacin No-Flush contains Inositol hexanicotinate, a form of niacin that is bound to inositol. This formation allows it to deliver niacin to the bloodstream slowly and in a controlled fashion, avoiding both the unpleasantness of flushing and the danger of liver damage.

References

Welsh AL, Ede M. Inositol hexanicotinate for improved nicotinic acid therapy. Int Record Med. 1961 Jan; 174(1): 9-15.