BenaGene

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BenaGene

AOR CODE: AOR04138

Your Key to a Long Healthy Life


  • Stimulates over 350 anti-aging genes

  • Shown to increase health and lifespan in animals

  • Balances blood glucose levels


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Use this product for: Anti-Aging Cellular Health Energy/Fatigue

Details

BenaGene™ is stabilized oxaloacetic acid, the world's first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bioavailable so that a one-a-day dosage is all that is required.  BenaGene offers the potential of longevity and vitality and is exclusively available in Canada from AOR. 

Caloric restriction is the only method proven to extend human lifespan and health span. BenaGene is a novel caloric restriction mimetic (CR mimetic), mimicking up to 98% of the changes in the genetic expression of over 350 genes in a similar fashion to caloric restriction. While human trials on BenaGene’s effects on life extension have not been conducted, human clinical trials have confirmed both reduction in glucose levels and an improved uptake of glucose without negative side effects. BenaGene appears to down-regulate pathways that create and store fat. Mitochondrial and cellular DNA damage is also thought to exacerbate aging, and BenaGene both protects and repairs DNA. 

Anyone who is interested in slowing down the aging process will want to consider taking BeneGene, as well as those who suffer from glucose imbalances. BenaGene is a perfect partner for resveratrol and other antioxidants, for even more powerful anti-aging effects.

Label Info

Discussion

BenaGene™ contains the first thermally stabilized oxaloacetate, a key compound in the body’s energy production cycle. benaGene™ provides antioxidants for the maintenance of good health

Product Variation

Product Code NPN Size
AOR04138 80039432 30 VEGI-CAPS

Supplements Facts

Serving Size: 1 capsule Amount
benaGene™ (3-carboxy-3-oxopropanoic acid) 100 mg
Vitamin C 100 mg
Non-medical ingredients:

microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take 1 capsule daily with food, or as directed by a qualified health care practitioner.

Cautions

Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you have diabetes. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia including feelings of anxiety, dizziness, tremor, sweating, nausea or headache.

Source

Pharmaceutical synthesis

Main Application

Antioxidant

Anti-aging

Glucose metabolism

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

What is benaGene™?

benaGeneTM is thermally stabilized oxaloacetate, the world’s first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bioavailable so that a one-a-day dosage is all that is required, making its exciting health benefits easy to swallow.   

The Key: A High NAD /NADH Ratio

NAD (nicotinamide adenine dinucleotide) is a niacin-derived coenzyme that is present in all living cells and is critical to the production of ATP – the body’s primary source of all immediate energy. Higher NAD levels are thought to have a stimulatory effect on beneficial genes whilst a high NADH concentration is thought to inhibit beneficial genes. benaGeneTMappears to promote a high NAD /NADH ratio.

 

Research

benaGene™, NAD and Oxidative Stress

benaGeneTM increases the conversion of NADH to NAD and also influences changes in the electrical state (Gibbs free energy) and critical signalling molecules. Oxaloacetate has also been found to prevent brain mitochondrial DNA damage in mice.

 

Market Trends

Oxaloacetate is not a well known nutritional supplement, but it shows ground-breaking potential in antioxidant research. benaGeneTM is thermally stabilized oxaloacetate, one of the first of its kind on the market.

AOR Advantage

benaGeneTM is a novel product at the pinnacle of antioxidant research. This product was introduced to Canada first by AOR in 2007 and is offered exclusively by AOR in Canada.

References

Bhattacharya, R. and R. Tulsawani, In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid. Drug Chem Toxicol, 2008. 31(1): p. 149-61.

Cash A., Modification of the NAD /NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010.

Cash, A., Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction. Open Longevity Science, 2009. 3: p. 22-27.

Chang, I., et al., Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes. Diabetologia, 2003. 46(9): p. 1220-7.

Desagher, S., J. Glowinski, and J. Premont, Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci, 1997. 17(23): p. 9060-7.

Desagher, S. and J.C. Martinou, Mitochondria as the central control point of apoptosis. Trends Cell Biol, 2000. 10(9): p. 369-77.

Farah, I.O., Differential modulation of intracellular energetics in A549 and MRC-5 cells. Biomed Sci Instrum, 2007. 43: p. 110-5.

Greer, E.L., et al., An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol, 2007. 17(19): p. 1646-56.

Hogan D., et al., (2010) Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle. FACSM Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine.

Nogueira L., (April 2011) Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle, Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, The Federation of American Societies for Experimental Biology

O’Donnell-Tormey, J., et al., Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med, 1987. 165(2): p. 500-14.

Puntel, R.L., C.W. Nogueira, and J.B. Rocha, Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. Neurochem Res, 2005. 30(2): p. 225-35.

Puntel, R.L., C.W. Nogueira, and J.B. Rocha, N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro. Neurochem Res, 2005. 30(3): p. 417-24.

Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-768.

Wood, J.P. and N.N. Osborne, Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells. Neurochem Res, 2003. 28(10): p. 1525-33.

Yoshikawa, K., Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med, 1968. 96(2): p. 127-41.

Yamamoto, H.A. and P.V. Mohanan, Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. Toxicol Lett, 2003. 143(2): p. 115-22.

Zlotnik, A., et al., Brain neuroprotection by scavenging blood glutamate. Exp Neurol, 2007. 203(1): p. 213-20.

 

 

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