Vegan, Biologically Active Forms of Folate and B12 in Researched Doses

  • A combination of folic acid (B9) and vitamin B12 in their active forms
  • Superior to Folic Acid
  • Required for DNA synthesis and cell repair
  • Supports the healthy development of the fetus during pregnancy
  • Prevents neural tube defects
  • Promotes cardiovascular health
  • Supports mood and cognitive functions
  • Ideal for Plant-based and Vegan diets
Corn Free
Gluten Free
Soy Free

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Folic acid (or folate) is vitamin B9, a water-soluble vitamin that plays a key role in DNA and RNA synthesis, red blood cell production, the metabolism of proteins, and healthy genetic expression. The body needs folic acid but can’t synthesize it on its own and as such must be consumed from foods or dietary supplements. Lifestyle, diet and some medications and diseases can deplete the body’s folate supply. BioFolate® contains L-5-methyltetrahydrofolate (L-5-MTHF), the active form of folate that is used in the body.

Taking folate in the form of L-5-MTHF ensures that even those with the MTHFR mutation are able to absorb the folate and avoid deficiency.




BioFolate® contains the preferred, biologically active forms of folate and vitamin B12. BioFolate® helps the body to metabolize carbohydrates, fats, and proteins and form red blood cells.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproducts.

AOR Advantage

AOR’s Biofolate™ provides a high dose of the active form of folate combined with active B12, as folate supplementation can mask a B12 deficiency. D-5-MTHF is an ineffective and potentially harmful version of the activated folate 5-MTHF that is actually banned in Europe. Some products exist on the market that are a 50/50 mix of the L-and D-forms, which have questionable efficacy, and may be harmful.

In accordance with AOR’s philosophy and quality control standards, all of AOR’s 5-MTHF products contain only the highest purity L-5-MTHF on the market, which is guaranteed to be greater than 99% L-5-MTHF.

Adult Dosage

Take 1 capsule daily with food, or as directed by a qualified health care practitioner.


Folate supplementation can mask a vitamin B12 deficiency. Consult a health care practitioner prior to use if you are uncertain whether or not you are taking adequate vitamin B12.

Main Applications
  • Cardiovascular health
  • Healthy red blood cells
  • Optimal methylation health

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: 1 Capsule
Amount Per Serving
% Daily Value
1 mg
Vitamin B12 (as Methylcobalamin)
2.8 mcg

Non-medical Ingredients: microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.

In a double-blind, multicenter study, elderly patients presenting with depression were treated with 5-methyltetrahydrofolic acid (5’-MTHF) in addition to their standard psychotropic medication. When these two therapies were combined, patients showed a significant improvement in clinical recovery from depression. Even in patients with normal folate levels, there was a reduction in depressive symptoms after 3 weeks of treatment with 5-MTHF.

This same study also looked at cognition in patients with dementia and depression. These elderly patients had normal folic acid levels, and were randomized to receive either 50mg per day of 5’MTHF folic acid, or the antidepressant drug Trazodone (100mg daily) for 8 weeks. Depression scores were significantly reduced in both groups, indicating that folic acid in this case was as good as Trazodone in decreasing symptoms of depression.

One study compared folic acid supplementation with 5’-MTHF for lowering homocysteine levels in patients with high serum homocysteine. Subjects aged 50-65 who were otherwise healthy (and who had normal serum folate levels) were given either 400mcg daily of folic acid or 5’MTHF. After 4 weeks of treatment both groups showed a significant decrease in homocysteine levels.

High levels of homocysteine (associated with folic acid deficiency) have been associated with an increased risk of Alzheimer’s dementia. 120 patients with cognitive impairment were enrolled in a study that evaluated the metabolism of homocysteine and folic acid. Higher levels of 5’MTHF in the cerebrospinal fluid of these patients seemed to be protective of “tau pathology” (hyperphosphorylation of a protein called tau that causes “tangles” in the brain) – a process that can cause or contribute to Alzheimer’s disease. As well, lower levels of 5’MTHF appeared to promote tau pathology and injury to brain cells in this study.

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