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Cardana Caps

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Cardana Caps

$41.95 CAD

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AOR CODE: AOR04269

A Powerful Ayurvedic Formula for the Heart

  • A combination of the most effective Ayurvedic herbs known to support the heart

  • Promotes healthy heart function, blood flow, blood pressure & vascular health

  • Reduces the heart-compromising effects of stress 

Use this product for: Heart Health
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Details

It is estimated that over 56 million Americans have some form of cardiovascular disease (CVD). Although CVD is increasingly common as people age, it is not an inevitable consequence of aging. Cardana Caps is an Ayurvedic herbal formula used to support the health of the heart and vascular system, promoting normal blood pressure and healthy blood flow to the heart muscle. It can promote a healthy heart rate, and reduces the effects of stress on the heart. 

Cardana Caps contains five of the most powerful herbs used to support the cardiovascular system and a healthy blood pressure. Terminalia arjuna reduces blood pressure and heart rate, and increases the strength of the heart’s contractions. Coleus forskohlii is a powerful vasodilator that reduces blood pressure, and improves the efficiency of the heart's contractions. Crataegus laevigata (also known as hawthorn), increases the force of cardiac contractions, improves blood flow, reduces the oxygen needs of the cardiac muscle, and is an anti-hypertensive and anti-arrhythmic agent. Boerhaavia diffusa is a diuretic, helping to reduce blood pressure. Withania somnifera, known as ashwagandha, supports cardiovascular health by reducing the effects of stress, which include a rapid pulse and increased blood pressure. 

Those looking to support a healthy blood pressure and improve heart function will benefit from this Ayurvedic heart formula. Type A personalities who are prone to heart and blood pressure problems will particularly find Cardana Caps helpful.

Label Info

Discussion

Cardana Caps is a formulation of botanicals used in traditional Ayurvedic Medicine to help maintain and/or support cardiovascular health in adults.

Product Variation

Product Code NPN Size
AOR04269 80040647 120 VEGI-CAPS

Supplements Facts

Serving Size: 1 Capsule Amount % Daily
Terminalia arjuna (8-10:1) 113 mg
Crataegus laevigata (2.2% flavonoids as hyperoside) 100 mg
Coleus forskohlii (10% forskolin) 50 mg
Withania somnifera (10:1) 50 mg
Boerhaavia diffusa (8:1) 50 mg

lactose monohydrate (from milk), maltodextrin, microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate, sodium & potassium sorbate. Capsule: hypromellose.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, eggs, fish or shellfish.

Adult Dosage

Take 1-2 capsules twice daily with/without food, or as directed by a qualified health care practitioner. Use for a minimum of 2 months to see beneficial effects

Cautions

Consult a health care practitioner prior to use if you are taking cardiac glycosides such as digitalis/digoxin, blood pressure medication, diuretics or anticoagulants/blood thinners. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Consult a health care practitioner if symptoms persist or worsen. Symptoms such as mild gastritis, constipation, headaches and/or vomiting have been known to occur, in which case discontinue use. Do not use if you are pregnant or breastfeeding.

Source

Botanical extracts

Main Application

Cardiovascular health

Blood pressure balance

Circulation

Oxygen sparing

Stress

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

Ayurvedic Heart Support

Many Ayurvedic herbs have powerful medicinal effects that are not well known in North America. Cardana Caps encompasses the Ayurvedic herbs that have been traditionally used to support cardiovascular health, especially blood pressure, some of which have been well researched in Western medicine and found to clinically support the heart.

1.) Terminalia arjuna bark. This Ayurvedic herb has been conclusively proven to have cardiovascular activity, helping to regulate blood pressure, slow the heart rate, and increase the force of the heart’s contractions.

2.) Coleus forskohlii. Helps regulate blood pressure and increases the force of the heart’s contractions.

3.) Crataegus laevigata (Hawthorn). Hawthorn, a plant used traditionally in Europe, is known for regulating blood pressure and plaque formation, and improving heart performance and metabolic parameters.

4.) Withania somnifera. Also known as ashwagandha, it has been described as the most important medicinal plant in India, being a part of numerous Ayurvedic formulas. It is primarily used as an adaptogen for stress, and stress is a great risk factor for cardiovascular disease. Ashwagandha has been used as a treatment for the most debilitating diseases and is included for its cardioprotective and anti-stress activities.

5.) Boerhaavia diffusa. Boerhaavia is a mild diuretic, helping to regulate blood pressure.

 

Research

1.) Terminalia arjuna bark. Studies have shown that extracts of Terminalia arjuna produce sustained hypotension and bradycardia which is dose-dependent. It has also been shown to increase the force of contraction of the heart in all doses. In a double-blind, placebo-controlled crossover study among heart patients, arjuna supplementation was able to ameliorate symptoms to such a degree that all patients had their conditions reclassified. Furthermore, arjuna increased the blood-pumping activity of their hearts by 10%, and the efficiency of those hearts at emptying blood out the left ventricle (ejection fraction) rose by nearly 20%. In the treatment of angina, studies have shown arjuna supplementation to be capable of reducing the frequency of attacks by two-thirds among stable angina patients. One study found that arjuna was as effective as isosorbide mononitrate (a common angina prevention medication) at reducing angina attacks and improving exercise capacity; patients also needed less isosorbide mononitrate when taking arjuna. Clinical trials have also been performed with heart attack patients with encouraging results.

2.) Coleus forskohlii. Detailed pharmacologic studies established that forskolin – a diterpene lactone – positively influenced blood pressure in different animal species, as well as in humans. In addition, it improved contractions of the heart muscle. The blood pressure regulating effects of forskolin were attributed to a decrease in pre and after loads as well as decreased peripheral resistance by a direct action on relaxing the arteriolar smooth muscle. Both the improve heart contractility and the vascular effects were shown to be initiated by the stimulation of the membrane-bound enzyme adenylate cyclase resulting in raised intracellular cAMP levels, an activation of protein synthesis, a lowering of the membrane-bound Na , K -ATPase activity and activation of the slow calcium gate.

3.) Crataegus laevigata (Hawthorn). The fruits from this plant act as a cardiotonic and coronary vasodilator. Hawthorn is reputed to promote the return to health of arteries. Various clinical studies have shown increased cardiac performance and output, decreases in peripheral resistance, pulmonary arterial and capillary pressures and blood pressure at rest and during exercise, and improved metabolic parameters. Recent human clinical studies have shown moderate decreases in LDL and non-HDL cholesterol, and slight decreases in diastolic blood pressure.

4.) Withania somnifera. This herb has been the focus of hundreds of clinical studies and is one of the most exhaustively researched herbs. The anti-stress activity of the roots has been reported in multiple clinical studies. A small pilot study in humans over 30 days showed that ashwagandha reduced LDL cholesterol, VLDL cholesterol, and triglycerides, had diuretic activity which helps reduce blood pressure, and reduced blood glucose as well as a conventional hypoglycemic drug.

5.) Boerhaavia diffusa. The cardiovascular action of this herb has been clinically studied. The rationale for its inclusion is due to its powerful diuretic activity which helps regulate blood pressure.

 

Market Trends

Of these five herbs, Hawthorn is the most popular herbal supplement for cardiovascular protection. Hawthorn is known for regulating blood pressure and supporting arterial health.

AOR Advantage

This formula is in line with AOR’s philosophy: combining several ingredients that have multiple mechanisms of action for a more effective, well-rounded and safe approach rather than taking large doses of the same ingredient in the hopes of a greater effect. Cardana Caps also highlights several traditional Ayurvedic herbs.

References

Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol. 2000 Jun;38(6):607-9.

Bharani A, Ganguli A, Mathur LK, Jamra Y, Raman PG. Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate. Indian Heart J. 2002 Mar-Apr;54(2):170-5.

Bharani A, Ganguly A, Bhargava KD. (1995). “Salutray effect of T. Arjuna in patients with severe refactory heart failure”. Int. J. Cardiol. 49: 191-199.

Blesher V.R. (1992). “Use of crataegus in cardiology. Fortscher Med. 15: 290-292.

Divivedi, S. et al. (1995). “Term. arjuria and prostaglandin E activity”. Indian Drugs 24: 378-382.

Heichrgens H. (1993). “Crataegus special extract WS 1442 in cardiac insuffiency NYH A II. A placebo-controlled randomized double blind study”. Fortschr Med. 111: 352-4.

Loew, D. (1997). “Phytotheraphy in heart failure”. Phytomedicine. 4: 267-271.

OÇonolly et al (1987). “Treatment of elderly, multimorbid patients with stenocardiac complaints with crateagus”. Therapiewoche. 37; 3587-3600.

Reichert, R (1996). “Terminalia arjuna for Congestive heart failure:. Quarterly Rev. of Nat-Med Fall; 177-178.

 

Abstract

Withania somnifera provides cardioprotection and attenuates ischemia-reperfusion induced apoptosis.

Mohanty IR, Arya DS, Gupta SK.

Clin Nutr. 2008 Aug;27(4):635-42. Epub 2008 Jul 11.

BACKGROUND AIMS: The present study was undertaken to evaluate the cardioprotective mechanisms of Withania somnifera (Ws), in the setting of ischemia and reperfusion (IR) injury.

METHODS: Wistar rats were divided into three groups and received orally saline (sham, control IR) and Ws-50 mg/kg (Ws-IR), respectively, for 1 month. On the 31st day, in the rats of control IR and Ws-IR group, LAD coronary artery occlusion was undertaken for 45 min followed by 1 h reperfusion. Subsequently, all the animals were sacrificed for biochemical, immunohistochemical {Bax and Bcl-2 protein}, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) positivity and histopathological studies.

RESULTS: Post-ischemic reperfusion injury resulted in significant cardiac necrosis, apoptosis, decline in antioxidant status and elevation in lipid peroxidation in the IR control group as compared to sham. Ws prior-treatment favorably restored the myocardial oxidant-antioxidant balance, exerted marked anti-apoptotic effects {upregulated Bcl-2 (p<0.001) protein, decreased Bax (p<0.01) protein, and attenuated TUNEL positivity (p<0.01)}, and reduced myocardial damage as evidenced by histopathologic evaluation.

CONCLUSIONS: The antioxidant and anti-apoptotic properties of Ws may contribute to the cardioprotective effects.

 

Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate.

Indian Heart J. 2002 Mar-Apr;54(2):170-5.

Bharani A, Ganguli A, Mathur LK, Jamra Y, Raman PG.

BACKGROUND: Terminalia arjuna, an Indian medicinal plant, has been reported to have beneficial effects in patients with ischemic heart disease in a number of small, open studies. The need for a double-blind, randomized, placebo-controlled study with adequate sample size has long been felt. The bark extract (IPC-53) contains acids (arjunic acid, terminic acid), glycosides (arjunetin arjunosides I-IV), strong antioxidants (flavones, tannins, oligomeric proanthocyanidins), minerals. etc. and exhibits antifailure and anti-ischemic properties.

METHODS AND RESULTS: Fifty-eight males with chronic stable angina (NYHA class II-III) with evidence of provocable ischemia on treadmill exercise test received Terminalia arjuna (500 mg 8 hourly), isosorbide mononitrate (40 mg/daily) or a matching placebo for one week each, separated by a wash-out period of at least three days in a randomized, double-blind, crossover design. They underwent clinical, biochemical and treadmill exercise evaluation at the end of each therapy which were compared during the three therapy periods. Terminalia arjuna therapy was associated with significant decrease in the frequency of angina and need for isosorbide dinitrate (5.69 /-6.91 mg/week v. 18.22 /-9.29 mg/week during placebo therapy, p<0.005). The treadmill exercise test parameters improved significantly during therapy with Terminalia arjuna compared to those with placebo. The total duration of exercise increased (6.14 /-2.51 min v. 4.76 /-2.38 min, p<0.005), maximal ST depression during the longest equivalent stages of submaximal exercise decreased (1.41 /-0.55 mm v. 2.21 /-0.56 mm, p<0.005), time to recovery decreased (6.49 /-2.37 min v. 9.27 /-3.39 min, p<0.005) and higher double products were achieved (25.75 /-4.81×10(3) v. 23.11 /-4.83×10(3), p<0.005) during Terminalia arjuna therapy. Similar improvements in clinical and treadmill exercise test parameters were observed with isosorbide mononitrate compared to placebo therapy. No significant differences were observed in clinical or treadmill exercise test parameters when Terminalia arjuna and isosorbide mononitrate therapies were compared. No significant untoward effects were reported during Terminalia arjuna therapy.

CONCLUSIONS: Terminalia arjuna bark extract, 500 mg 8 hourly, given to patients with stable angina with provocable ischemia on treadmill exercise, led to improvement in clinical and treadmill exercise parameters as compared to placebo therapy. These benefits were similar to those observed with isosorbide mononitrate (40 mg/day) therapy and the extract was well tolerated. Limitations of this study include applicability of the results to only men with chronic stable angina but not necessarily to women, as they were not studied.

 

Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.

Indian J Exp Biol. 2000 Jun;38(6):607-9.

Andallu B, Radhika B.

Hypoglycemic, diuretic and hypocholesterolemic effects of roots of W. somnifera (ashvagandha) were assessed on human subjects. Six mild NIDDM subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of W. somnifera for 30 days. Suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period. Decrease in blood glucose was comparable to that of an oral hypoglycemic drug. Significant increase in urine sodium, urine volume, significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density lipoproteins) cholesterol were observed indicating that root of W. somnifera is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents. Clinical observations revealed no adverse effects.

 

Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy–a comparative study with dobutamine and sodium nitroprusside.

Baumann G, Felix S, Sattelberger U, Klein G.

J Cardiovasc Pharmacol. 1990 Jul;16(1):93-100.

Forskolin, a diterpene derivative of the Indian plant Coleus forskhohlii, proved to be a marked positive inotropic and vasodilatory compound in animal experiments with a mechanism of action distinct from catecholamines, cardiac glycosides, and phosphodiesterase-inhibiting compounds. The cardiovascular effects of forskolin seem to be mediated by a direct stimulatory action at the catalytic unit of sarcolemmal adenylate cyclase. The aim of the present study was to clarify the cardiovascular profile of this compound in 12 patients with stage III (NYHA) congestive cardiomyopathy. The effects of forskolin were investigated by invasive techniques using the thermodilution catheter method and compared to the beta 1-receptor agonist dobutamine and the vasodilator sodium nitroprusside in an intraindividual comparison. Forskolin dose-dependently reduced cardiac pre- and afterload values, and led to a reduction in systolic, diastolic, and mean pulmonary artery pressure as well as pulmonary wedge pressure by greater than 50% concomitant with an increase in cardiac output. There was a slight increase in heart rate. Cardiac stroke volume and stroke volume index was increased by approximately 70%. The cardiovascular effects of dobutamine and nitroprusside were less pronounced; however, it seemed that a similar hemodynamic profile could be achieved by the combination of both dobutamine and sodium nitroprusside. In view of the rapid development of tolerance toward beta 1-receptor stimulation, forskolin, with its receptor-independent mechanism of action, may be advantageous for…..

 

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