CurcuMIND

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CurcuMIND

AOR CODE: AOR04259

Curcumin Optimized with Vitamin D for Cognitive Support

Synergistic combination of curcumin and vitamin D3

Contains Longvida curcumin, clinically proven to improve brain health and memory

Supports balanced immunity

Powerful anti-inflammatory

Use this product for: Auto-Immunity Brain Health

Details

CurcuMIND provides a high dose of Longvida optimized curcumin in synergy with vegan vitamin D3, a first in the world combination from AOR. CurcuMIND is designed for individuals wanting cognitive support for improved memory, attention, mood and alertness. 

Curcumin and vitamin D3 work together to protect brain cells against the effects of toxic beta-amyloid proteins, which have been linked to cognitive decline. Together, these ingredients have been shown to support the clearance of beta-amyloid, repair nerve function in the brain, and positively affect mood and behaviour. While standard curcumin supplements suffer from poor absorption, Longvida provides the solution to this problem with improved bioavailability. Longvida has several studies in healthy humans showing that just 80 mg daily improved cognitive function, memory, attention, mood and alertness, while reducing blood levels of beta-amyloid in just 30 days. 

CurcuMIND can also provide support for autoimmune conditions and inflammation related to autoimmunity since curcumin and vitamin D work synergistically to modulate immune function. Up to 9 capsules of CurcuMIND per day will provide powerful support for those suffering from age-related cognitive decline, poor focus and concentration, inflammation and auto-immune disorders.

Label Info

Discussion

Only free-form curcumin crosses the blood-brain barrier, and Longvida® optimized curcumin delivers highly bioavailable free-form curcumin with superior clinical results. CurcuMIND provides synergistic antioxidants for the maintenance of good health.

Product Variation

Product Code NPN Size
AOR04259 80024708 90 VEGI-CAPS

Supplements Facts

Serving Size: 3 Capsules Amount
Longvida® Optimized Curcumin* (from Curcuma longa root 25-30:1) 400 mg
Vitamin D3 (vegan, from lichen) 333 IU/ 8.33 mcg

*LONGVIDA® is a registered trademark of Verdure Sciences Inc. International, patent pending.

Non-medical ingredients:

ascorbyl palmitate, microcrystalline cellulose, soy lecithin, stearic acid, maltodextrin, silicon dioxide, tocopherols, corn starch, sucrose, sodium stearyl fumarate. Capsule: hypromellose.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take 3 capsules three times daily with/without food, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner prior to use if you are pregnant, taking antiplatelet medication or blood thinners, or have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.

Source

Longvida® Optimized Curcumin (from Curcuma longa / turmeric root)

Main Application

Antioxidant

Cognitive health

Inflammation

Healthy cellular growth and differentiation

Lipid metabolism

Gastrointestinal health

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

CurcuMIND provides a high dose of Optimized Curcumin in synergy with vegan vitamin D3, a first in the world combination from AOR. Optimized Curcumin was specially formulated to provide a solution to the curcumin conundrum of low bioavailability, poor absorption and rapid breakdown. Although bioavailability and absorption help determine effectiveness, the key lies within its ability to remain free. This free state of curcumin is achieved due to the formula’s ability to avoid being rapidly broken down within the body. Because free curcumin retains its “unbroken” form, it is then taken up through the blood stream where it is stable, concentrated, and retains maximum effectiveness for up to 24 hours, making it the most effective, absorbable curcumin available for cognitive health.

CurcuMIND is designed to support cognition and protect brain cells against the effects of toxic beta-amyloid proteins. In vitro studies with curcumin and vitamin D3, alone and in combination, have been found to support the clearance of beta-amyloid. In mice, curcumin helped repair nerve function in the brain and positively affected their behaviour. Finally, a study in healthy humans showed that just 80 mg of Optimized Curcumin reduced blood levels of beta-amyloid in just 30 days – a feat that other “bioavailable” curcumin have failed to accomplish.

CurcuMIND can also provide support for autoimmune conditions and inflammation related to autoimmunity since curcumin and vitamin D work synergistically to modulate immune function.

Up to 9 capsules of CurcuMIND per day will provide powerful support for those suffering from age-related cognitive decline, severe inflammation, auto-immune disorders and supports healthy cellular growth & differentiation.

Free Yourself, with Free-Form Curcumin

Turmeric, Curcumin & Bioavailability – What’s All The Hype About?

Curcumin is well known for its anti-inflammatory and pain relieving properties, which are well supported by clinical studies. These studies have shown that curcumin is highly effective for improving joint mobility and for reducing stiffness, swelling and pain. However, until recently, very high doses of curcumin (over 8 g per day) have been required to achieve these results due to weak turmeric extracts that provide only 2% curcumin, and to the poor bioavailability of curcumin. Studies suggest that you need to take more than 8g of a regular 95% curcumin extract, which is somewhere between 10 and 20 capsules, before it becomes detectable in your blood! Taking this many capsules per day just to achieve an effective dose is highly inconvenient and costly! Furthermore, many products on the market are highly misleading, and may not be effective at all! Being aware of what is actually in each product and taking advantage of the latest advances in nutraceutical technology can help to ensure that you are getting the best possible curcumin supplement, and therefore the most effective relief from pain and inflammation.

Optimized Curcumin – Discover The Benefits

AOR’s Optimized Curcumin products are based on proven Solid Lipid Particle™ (SLP) technology and have the following advantages:

The only curcumin shown to be free from rapid breakdown within the body and remain in its free form within the blood stream for up to 24 hours! Other so-called bioavailable curcumins result in various metabolites in the blood that have been broken down (ie. glucuronides) and are no longer active or effective, making their improved bioavailability useless.

Clinically tested bioavailability in human subjects, notably in diseased patients, with results published in the prestigious Journal of Agricultural and Food Chemistry (Gota et al., 2010).

A 100-fold increase in bioavailability compared to regular curcumin. No other curcumin on the market has been proven to have this kind of bioavailability. Other so-called bioavailable curcumin products have maximum bioavailability improvements of 30-fold or less.

A recent human study (DiSilvestro et al., 2012) shows that a low dose of 1 capsule of 80 mg Optimized Curcumin reduces blood levels of beta-amyloid in healthy people in just 1 month!

Vegan formula

Optimized Curcumin consists of Solid Lipid Particles™ (SLP). This process involves a unique combination of highly purified lipids that coat the curcumin particles, which are also significantly reduced to 1 millionth of a millimeter in size. This combination is organized in such a way as to increase bioavailability and absorption, and remarkably avoid being rapidly broken down within the body. This unique formulation allows for each solid lipid curcumin particle to be taken up through the lymph system, as opposed to being absorbed directly into the circulation and broken down by the liver, therefore avoiding “first pass metabolism” or glucuronidation. The liver is the major organ responsible for metabolizing or breaking down substances. When something is ingested, it is either glucuronidated or sulphated by the liver. This process involves adding a glucuronide or sulphate group to the substance, making it extremely soluble. It is then carried to our kidneys and bowel and is ready for excretion. When curcumin is able to avoid this rapid breakdown, it retains its activity as free form curcumin. When it cannot, it is excreted out of the body rapidly, which is unfortunately the case with all other curcumins on the market. Finally, the tiny particle size and the lipid coating allows the curcumin to be taken up into the body’s cells quickly and put to use. This means that it delivers all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster and more effectively than any other curcumin product. Do you want to free yourself, with free form curcumin?

 

Try our Optimized Curcumin products today and start feeling the benefits of a true high-potency, free form curcumin supplement.

 

Research

Bioavailability

Gota and colleagues did a safety and bioavailability study on healthy volunteers versus patients. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 1 to 2 capsules of CurcuMIND). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events.

Longvida® Curcumin in Humans

A new ground-breaking study is the first to show cognitive improvements with an Optimized Curcumin formula. A 30-day study in healthy older adults found that Optimized Curcumin not only enhanced memory, mood, alertness and cholesterol after 30 days, but it improved cognitive function after just 1 hour after taking it the first day!

A human trial on curcumin showed statistically significant effects on clinical endpoints in a healthy population. The fact that such a low dose (80 mg) was needed to achieve effects in only 30 days is an interesting and unique finding as well, and adds to the substantial amount of pharmacokinetic and pharmacodynamic data compiled on Longvida®. The results of the study suggest that curcumin can produce beneficial effects in people who are without immediate disease states. The study was conducted on 38 healthy middle aged people between the age of 40 and 60 who were either given a dose of 80 mg/day of Longvida® curcumin extract for four weeks or were a part of the 19 person placebo group. The study is particularly interesting because the relatively small dose of curcumin, from Longvida® which was used, exerted a variety of health promoting effects leading researchers to presume that a significant amount of the curcumin was absorbed, although not tested directly.

Blood sample readings collected from test subjects to assess nitric oxide and sICAM molecules were notably affected by the curcumin. Interestingly, other markers of inflammation and free radicals/toxic species that cause inflammation and damage to cells were also significantly lowered. Both direct and indirect antioxidant actions of curcumin were evident in the subjects; these findings are consistent with in vitro and animal studies used to measure increases in curcumin induced antioxidant enzyme activity.

 

Market Trends

New Technology – Better Products!

Numerous supplements on the market contain the curcumin extract of turmeric. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability. Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose in as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is nano-technology.

 

AOR Advantage

Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. CurcuMIND is clinically proven to deliver several health benefits as a result of its high bioavailability and has the following advantages:

Clinically tested with results published in 2010 in the prestigious Journal of Agricultural and Food Chemistry. In the study, patients experienced few to no adverse effects and good tolerability of the equivalent of up to 9 capsules of CurcuMIND

Higher bioavailability compared to regular curcumin

Patented by the University of California

Recent human study showing positive effects on markers of health with just 80 mg of Longvida® curcumin per day for 1 month.

CurcuMINDTM consists of solid lipid particles (SLP) which are tiny particles that have a protected layer that provides a phenomenal increase in stability, potency and effectiveness. Unlike regular curcumin that is easily broken down by stomach acids, Curcumin Fast Relief particles are resistant to acid breakdown. Even more important is the fact that these tiny particles are absorbed very rapidly. This means that they deliver all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster than any other curcumin product. Try CurcuMINDTM today and start feeling the benefits of a real high-potency, high-bioavailability curcumin supplement.

 

References

Baum et al. Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease. Journal of Clinical Psychopharmacology. 2008; 28(1): 110-113.

Begum AN et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease.  J Pharmacol Exp Ther. 2008 Jul;326(1):196-208

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2014 Oct 2. 

Fiala M, Mahanian M, Rosenthal M, Mizwicki MT, Tse E, Cho T, Sayre J, Weitzman R, Porter V. MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer’s disease by vitamin D and curcuminoids. J Alzheimers Dis. 2011;25(1):135-44.

Frautschy, SA. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.

Gota VS et al. Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers. J Agric Food Chem. 2010; 58(4): 2095-2099.

Hamaguchi T et al. REVIEW: Curcumin and Alzheimer’s Disease. CBS Neuroscience and Therapeutics. 2010; 16(5): 285-297.

Haussler MR et al. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutrition Reviews. 2008; 68: S98-S112.

Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwickie M, Cashman J, Fiala M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2009;17(3):703-17.

Ray B, Lahiri DK. Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009 Aug;9(4):434-44.

 

Abstract

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.

J Psychopharmacol. 2014 Oct 2.

Cox KH, Pipingas A, Scholey AB.

Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic (1 and 3 h after single dose following chronic treatment) effects of solid lipid curcumin formulation (400 mg as Longvida®) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85. One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. Working memory and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress) were significantly better following chronic treatment. A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures. To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioral effects in humans. Results highlight the need for further investigation of the potential psychological and cognitive benefits of curcumin in an older population.

 

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. 

Nutr J. 2012 Sep 26;11:79.

Disilvestro RA, Joseph E, Zhao S, Bomser J.

BACKGROUND: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.

METHODS: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.

RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.

CONCLUSION: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.

 

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers.

J Agric Food Chem. 2010; 58(4): 2095-2099.

Gota VS et al.

Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose−plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.

 

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.

Nutrition Reviews. 2008; 68: S98-S112.

Haussler MR et al.

The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyvitamin D3. We report novel dietary ligands for VDR including curcumin, γ-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR.

 

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