D-Glucarate Milk Thistle is designed to support detoxification and overall liver health and function. It is especially helpful in the elimination of excess hormones.
D-Glucarate is a phytochemical that supports detoxification and is found naturally in many plants, including cruciferous vegetables like broccoli, cauliflower, kale and bok choy. It is also produced inside the body but only in small amounts that decrease with age. D-Glucarate supports glucuronidation, an important detoxification pathway within the body designed to eliminate potentially carcinogenic pathogens through the urine or the bile. D-Glucarate can be particularly effective in protecting hormone sensitive tissues such as the breast and prostate. Interestingly, people exposed to a toxic environment and with certain severe illnesses have been shown to have abnormally low levels of D-glucarate.
Milk thistle is an herb that has been used as a traditional remedy for over 2000 years, primarily for supporting overall liver health. Milk thistle protects the liver against toxins and supports liver function including detoxification and regeneration. Milk thistle has also been shown to inhibit the growth of abnormal cells, protect healthy cells, and protect against chemotherapy-induced liver toxicity.
D-Glucarate Milk Thistle is an excellent addition to a detoxification program, or for anyone simply looking for a supplement to support the healthy metabolism of hormones and toxins.
D-Glucarate + Milk Thistle contains milk thistle which helps to support liver function and is used as a liver protectant.
|Serving Size: 2 Capsules||Amount|
|Calcium D-Glucarate||150 mg|
|Milk Thistle dry extract (80% silymarin)||175 mg|
|Non-medical ingredients: |
microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.
Take 1 capsule twice daily with food, or as directed by a qualified health care practitioner. Use for a minimum of 3 weeks to see beneficial effects.
Consult a health care practitioner prior to use if you are taking other medications or antibiotics, for use beyond 28 days, or if symptoms persist or worsen. Do not use if you are pregnant or breastfeeding, have a liver or eye condition, or have Sly disease. Discontinue use if hypersensitivity develops (such as an allergy) or if symptoms of liver trouble or corneal clouding develop.
Milk Thistle dry extract
Healthy cellular growth
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
D-glucarate is a substance made in small amounts by the body but found mainly in foods like oranges and cruciferous vegetables like broccoli. Interestingly enough, such foods also contain other substances that promote detoxification and protect the cells, including glucoraphanin glucosinolate (SGS), IP6, DIM and I3C. D-Glucarate reduces the activity of the killer beta-glucuronidase enzyme in tissues all over the body, including key organs like the liver, spleen, breast, lung, and prostate resulting in higher net glucuronidation activity. This boost to your body’s glucuronidation capacity helps to ensure that those pollutants and toxins that have been neutralized by UGT enzymes (uridine 5′-diphospho-glucuronosyltransferase) will stay neutralized, and be safely passed out through the urine or the bile.
Every moment of every day, every cell in your body is under attack by chemical and biological weapons with the potential to cause harm and disease. Toxic compounds include not just artificial chemicals (such as persistent organic pollutants (POPs)) in the form of organochlorine pesticides and other such chemicals), but ancient, and even naturally-occurring substances, including polycyclic aromatic hydrocarbons (PAH), heterocyclic amines (HCAs), fungal toxins (such as aflatoxin), and even excess levels of the sex hormones estrogen and testosterone.
Glucuronidation: Phase II Detoxification
The body makes use of intricate detoxification pathways to process xenobiotic and naturally occurring toxins. One of the most important of such pathways is glucuronidation, in which UGT enzymes (uridine 5′-diphospho-glucuronosyltransferase) neutralize toxins by binding them to a molecule of glucuronic acid. This is an essential part of phase II detoxification. Glucuronidation renders potential carcinogens less hazardous to the cells of the body. It also makes many such chemicals easier for the body to excrete through the urine or the bile. Glucuronidation generally glucuronidates chemical toxins, steroid hormones, and other lipid-soluble toxins to either neutralize or detoxify them. The vital neutralization of toxins by glucuronidation can be undone by an enzyme known as beta glucuronidase. This enzyme frees up the original toxin from its glucuronic acid “handcuffs.” Beta-glucuronidase is present in the body’s cells and is also produced by some fecal bacteria. The activity of beta-glucuronidase increases with age.
D-Glucarate & Disease
As you’d expect from a nutrient that is used up in the detoxification process, people exposed to a toxic environment have abnormal levels of D-Glucarate in their tissues and biological fluids. Impaired glucuronidation has been linked to susceptibility to many diseases in humans and in other species. Human research reveals links between toxic environments, glucuronidation, and beta-glucuronidase; and also between glucuronidation, beta-glucuronidase activity and disease. Beyond supporting the body’s detoxification systems, D-Glucarate supplements also appear to make the cells of the body themselves less prone to stimulation by toxins. This property is also shared by milk thistle!
Milk thistle has been used for thousands of years in traditional medicine to help treat various liver diseases. Early clinical studies examined its therapeutic effects in certain liver diseases. It is known for protecting the liver and helping the liver self-regenerate after damage, helping to maintain and improve the general functioning of the liver. The liver has many functions, one of which is detoxification. When the liver is functioning optimally, detoxification can occur more efficiently. When any part of the detoxification system is compromised, including liver function, toxins can build-up in the body, causing illness and disease.
Silymarin’s Benefits for the Liver
More recent studies have isolated silymarin, milk thistle’s main active ingredient, which is actually a group of flavonolignans called silybins. These studies are beginning to discover just how powerful silymarin can be. It acts as an antioxidant, protecting cells, especially liver cells, from free-radical damage. It also protects cell membranes from lipid peroxidation, making them more stable and functional thereby protecting the cells. It might even protect cells by occupying hepatocyte binding sites so that toxins can’t penetrate into the cells. Silymarin stimulates DNA synthesis in hepatocytes, the liver cells, which promotes liver tissue repair and regeneration. Since the liver is where most detoxification happens, it’s important to keep it functioning optimally.
More of Milk Thistle’s Power Revealed
It also helps prevent inflammation in various tissues by inhibiting NF-kB and modulating other pro-inflammatory signals, making it potentially therapeutic in the many illnesses related to inflammation. Other studies have demonstrated metal-chelating effects of silymarin, including iron and arsenic. One study even found that milk thistle protected both the liver and the heart from chemotherapy damage.
Silymarin also appears to benefit metabolic parameters. The results of one study showed significant improvements in various cholesterol and blood sugar parameters such as LDL, triglycerides, fasting blood glucose, HbA1c and others in silymarin treated patients.
Detoxification products are commonly purchased health supplements. However, not all of these detoxification products are proven to be effective or are backed by genuine scientific evidence. Some of the more common and unproven ways of detoxifying the body are by using foot patches, body wraps and ionic foot baths. Unfortunately, many of the dietary detoxification products on the market are not properly formulated to support the body throughout the detoxification process.
Milk thistle and D-Glucarate are backed by extensive clinical research which attests to their benefits in assisting the body with the detoxification process and cellular protection. In combination, these two ingredients provide optimal support to the liver and protect the cells from toxins.
Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley RW Jr, Webb TE. “Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis.” Anticancer Res. 1995 May-Jun; 15(3): 805-10.
Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336-9.
Cheng B, Gong H, Li X, Sun Y, Zhang X, Chen H, Liu X, Zheng L, Huang K. Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. Biochem Biophys Res Commun. 2012 Mar 16;419(3):495-9. Epub 2012 Feb 14.
Heerdt AS, Young CW, Borgen PI. “Calcium glucarate as a chemopreventive agent in breast cancer.” Isr J Med Sci. 1995 Feb-Mar; 31(2-3): 101-5.
Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2006 Dec;20(12):1036-9.
Kaur G, Athar M, Alam MS. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Invest New Drugs. 2010 Oct;28(5):703-13.
Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011 May 14;17(18):2288-301.
Maroni M, Columbi A, Antonini C. “D-glucaric acid urinary excetion as a tool for biological monitoring in occupational medicine.” In Brown SS, Davies DS (eds). Organ-directed toxicity: chemical indices and mechanisms. Oxford; Pergamon Press,1981:161-8.
Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer’s disease mouse model. Biosci Biotechnol Biochem. 2010;74(11):2299-306.
Muthumani M, Prabu SM. Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicol Mech Methods. 2012 Jan 9.
Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006 Nov;124(5):491-504.
Raškovi? A, Stilinovi? N, Kolarovi? J, Vasovi? V, Vukmirovi? S, Mikov M. The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules. 2011 Oct 12;16(10):8601-13.
Saller R, Melzer J, Reichling J, Brignoli R, Meier R. An updated systematic review of the pharmacology of silymarin. Forsch Komplementmed. 2007 Apr;14(2):70-80.
Tukey RH, Strassburg CP. “Human UDP-glucuronosyltransferases: metabolism, expression, and disease.” Annu Rev Pharmacol Toxicol. 2000; 40: 581-616.
Walaszek Z., Hanausek M., Szemraj J, Adams A. “D-Glucaric acid as a potential tumor marker.” In Hanausek M, Walaszek Z (eds). Methods in Molecular Medicine, Vol 14: Tumor Marker Protocols. 1998; Humana press, Totowa, NJ: 487-95.
Walaszek Z, Szemraj J, Narog M, Adams AK, Kilgore J, Sherman U, Hanausek M. “Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention.” Cancer Detect Prev. 1997; 21(2): 178-90.
Effects of A Breast-Health Herbal Formula Supplement on Estrogen Metabolism in Pre- and Post-Menopausal Women not Taking Hormonal Contraceptives or Supplements: A Randomized Controlled Trial.
Breast Cancer (Auckl). 2010 Dec 16;4:85-95.
Laidlaw M, Cockerline CA, Sepkovic DW.
INTRODUCTION: Both indole-3-carbinol and dietary lignans have beneficial effects on estrogen metabolism. There is no published literature on the effects of a combination product. This study was designed to investigate the impact of a combination product on estrogen metabolism. The major trial objective was to determine whether a breast health supplement containing indole-3-carbinol and hydroxymatairesinol lignan would alter estrogen metabolism to favour C-2 hydroxylation and reduce C-16 hydroxylation.
METHODS: Forty-seven pre-menopausal and forty-nine post-menopausal women were recruited for this study, and were divided by random allocation into treatment and placebo group. The treatment supplement contained HMR lignan, indole-3-carbinol, calcium glucarate, milk thistle, Schisandra chinesis and stinging nettle, and each woman consumed either treatment or placebo for 28 days. At day 0 and day 28, blood samples were analysed for serum enterolactone concentrations, and first morning random urine samples were assessed for estrogen metabolites. Repeated measures ANOVA statistical testing was performed.
RESULTS: In pre-menopausal women, treatment supplementation resulted in a significant increase (P < 0.05) in urinary 2-OHE concentrations and in the 2:16α-OHE ratio. In post-menopausal women, treatment supplementation resulted in a significant increase in urinary 2-OHE concentrations. In pre- and post-menopausal women combined, treatment supplementation produced a significant increase in urinary 2-OHE concentration and a trend (P = 0.074) toward an increased 2:16α-OHE ratio. There were no significant increases in serum enterolactone concentrations in the treatment or placebo groups.
CONCLUSIONS: Supplementation with a mixture of indole-3-carbinol and HMR lignan in women significantly increased estrogen C-2 hydroxylation. Further studies with higher numbers of subjects are indicated.
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
Indian J Med Res. 2006 Nov;124(5):491-504.
Pradhan SC, Girish C.
Silymarin, a flavonolignan from ‘milk thistle’ (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review we discuss about its safety, efficacy and future uses in liver diseases. The use of silymarin may replace the polyherbal formulations and will avoid the major problems of standardization, quality control and contamination with heavy metals or bacterial toxins. Silymarin consists of four flavonolignan isomers namely–silybin, isosilybin, silydianin and silychristin. Among them, silybin being the most active and commonly used. Silymarin is orally absorbed and is excreted mainly through bile as sulphates and conjugates. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It acts by antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, immunomodulatory and liver regenerating mechanisms. Silymarin has clinical applications in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug induced liver diseases and in diabetic patients. Though silymarin does not have antiviral properties against hepatitis virus, it promotes protein synthesis, helps in regenerating liver tissue, controls inflammation, enhances glucuronidation and protects against glutathione depletion. Silymarin may prove to be a useful drug for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs. The non-traditional use of silymarin may make a breakthrough as a new approach to protect other organs in addition to liver. As it is having a good safety profile, better patient tolerability and an effective drug at an affordable price, in near future new derivatives or new combinations of this drug may prove to be useful.
Altern Med Rev. 2002 Aug;7(4):336-9.
Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.
All rights Reserved. Copyright © by AOR 2019