Fem Ease

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Fem Ease

AOR CODE: AOR04332

A Natural Solution for Menstrual Pain


  • Powerful, natural muscle pain formula

  • Helps relieve menstrual pain and cramping

  • Reduces menstrual headaches



 


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Use this product for: Menstrual Cycle/PMS Sports Nutrition

Details

Many women experience pain before and during their menses that can range from mild to debilitating. Fem Ease was designed as a combination of well-studied and natural ingredients to target the causes of dysmenorrhea (menstrual pain): namely, muscle tightness and inflammation. L-Carnitine, ginger and curcumin have all been shown to help reduce muscle cramping, pain and inflammation related to menstruation, and support muscle recovery. Ginger has even been shown to be as effective as over the counter pain killers known as NSAIDs. Magnesium and California poppy provide mood support and relaxation effects, which is important since moodiness and higher stress have been linked to greater menstrual pain. 

Fem Ease can be taken several days before and during menstruation, to help relieve the physical symptoms of premenstrual syndrome (PMS) and dysmenorrhea. For mood support related to PMS, Fem Ease is best used with Fem Calm. Fem Ease can also be used by both men and women to help relax tight neck and back muscles, relieve general inflammation and reduce headache pain. It can even benefit athletes and those who experience frequent muscle tension to relieve muscle pain and discomfort.

Label Info

Discussion

Fem Ease helps relieve pain associated with menstruation, is traditionally used in Herbal Medicine as an analgesic and sedative, and is traditionally used in Ayurveda to relieve pain and inflammation.

Product Variation

Product Code NPN Size
AOR04332 80047080 60 VEGI-CAPS

Supplements Facts

Serving Size: 3 Capsules Amount
Magnesium (bisglycinate) 100 mg
Optimized Curcumin* (Curcuma longa root 25-30:1) 40 mg
California Poppy extract (Eschscholzia californica 10:1) 20 mg
L-Carnitine (tartrate) 680 mg
Ginger extract (Zingiber officinale 10:1) 100 mg

*LONGVIDA® is a registered trademark of Verdure Sciences Inc. International, patent pending.

Non-medical ingredients:

stearic acid, ascorbyl palmitate, soy lecithin, maltodextrin, gum arabic, microcrystalline cellulose, silicon dioxide, sodium stearyl fuamrate. Capsule: hypromellose

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, peanuts, sulphites, dairy, eggs or any animal byproduct.

Adult Dosage

For menstrual pain relief, take 3 capsules two to three times daily, 2 days prior to menstruation until 3 days afterward. For pain and inflammation relief, analgesic, or sedative effects, take 3 capsules one to three times daily. Take with food, or as directed by a qualified health care practitioner.

Cautions

Do not use if you are pregnant. Consult a health care practitioner prior to use if you are breastfeeding, taking antiplatelet medication or blood thinners, if you have gallstones, a bile duct obstruction, stomach ulcers, excess stomach acid, liver or kidney disease, or a seizure disorder. Consult a health care practitioner if symptoms persist or worsen. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Consumption with alcohol, other medications or natural health products with sedative and/or analgesic properties is not recommended.

Source

Botanical extracts

Pharmaceutical synthesis

Main Application

Women's health

PMS

Muscle pain

Menstrual migraines

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

Introducing Fem Ease

If you suffer from physical symptoms of PMS like cramps, then Fem Ease is for you. Fem Ease is formulated with several natural ingredients that when taken several days before and during menstruation, help relieve menstrual pain, cramps and other physical symptoms of PMS.

What Causes Painful PMS, and What Can Help?

Dysmenorrhea is painful menstrual cramps that stem from the uterus. As many as 25% of women are affected by it, and up to 40% of that portion of women experience pain so severe that it disrupts daily activities, causing them to miss work, school and other activities.

Although researchers are still uncertain exactly why some women experience PMS and painful menstrual cycles while others don’t, a group of researchers found that PMS was more prevalent in schoolgirls who were overweight, dieting, regularly ate junk food or not doing regular physical activity, and that menstrual cramps were more common in those who dieted or ate less food. This suggests that food, physical activity and lifestyle choices are important factors for a healthy menstrual cycle.

Stress has also been found to be a large contributing factor to dysmenorrhea. California poppy is traditionally used in Herbal Medicine as a mild sedative or sleep aid and analgesic, effects that are mediated by 5-HTP receptors in the brain which control mood. High levels of stress have been correlated with worsening of the typical symptoms associated with PMS. Therefore, obviating stress by using California poppy may help ease menstrual cramps. The analgesic effects of California poppy also help reduce pain.

Reduced Magnesium levels have been reported in women with primary dysmenorrhea. A human clinical study showed that magnesium is able to relieve premenstrual mood changes. A depressed mood has been linked with increased PMS pain, therefore supplementing magnesium may help decrease menstrual pain by relieving mood changes during menstruation. Magnesium also helps muscles relax and is clinically used for chronic pain and muscle spasms. Magnesium glycinatealso provides glycine, an amino acid with a calming effect.

Prostaglandins are locally acting hormones that act as pro-inflammatory molecules, and they can also make pain receptors more sensitive. The cells lining the uterus produce prostaglandins when an egg is not implanted, and this causes the uterus to contract to shed the lining that has built up over the cycle. A thicker lining is thought to produce more prostaglandins. It is thought that excessive prostaglandin production in the uterus is responsible for causing the cramping, back pain, headaches, nausea and other physical symptoms of PMS. This is what makes anti-inflammatories useful for physical PMS symptoms.

Curcumin, a powerful anti-inflammatory that regulates prostaglandin production, is the most active curcuminoid component of turmeric. Turmeric is a yellow Indian spice used in Traditional Chinese Medicine (TCM) to relieve pain of menstruation due to blood stasis and in Ayurvedic medicine to help relieve abdominal cramps and intestinal disorders. 1-4 grams per day of dried rhizome has been shown to reduce pain and inflammation, and 3-9 grams per day can be used for menstruation. Thankfully, there is Longvida® curcumin, a cutting edge, highly bioavailable and effective curcumin formula which provides the equivalent of 4 grams of curcumin in just three capsules of Fem Ease.

Ginger is known to help prevent nausea and vomiting. However, Ginger has also been shown to be as effective as NSAIDs in treating primary dysmenorrhea. Ginger reduces prostaglandin activity and synthesis, which helps relax the uterus muscles and reduces pain.

Inflammation is always accompanied by oxidative stress. L-Carnitine is made from the amino acids lysine and methionine; it reduces oxidative stress in the muscles and supports muscle recovery and muscle tissue repair. L-Carnitine may help mitigate the increased oxidative stress and decreased anti-oxidant levels that have been reported to be associated with primary dysmenorrhea cases.

 

Research

Ginger

In a double-blind comparative clinical trial, 150 participants suffering from primary dysmenorrhea enrolled to take either one of 250 mg of ginger rhizome powder (4:1 extract), 250 mg mefenamic acid or 400 mg ibuprofen four times per day for 3 days. At the end of treatment, the severity of dysmenorrhea significantly decreased in all groups and no significant differences were found between the groups in severity of dysmenorrhea, pain relief, or satisfaction with the treatment. This shows that ginger was as effective in relieving the pain of dysmenorrhea as two NSAIDs (non-steroidal anti-inflammatory drugs) commonly used for menstrual pain.

In a placebo-controlled trial, 70 participants took either 1.5 g of ginger rhizome powder or placebo per day for 3 days for primary dysmenorrhea. The mean change in pain score (before and after supplementation) in the ginger group was significantly greater than that in the placebo group.

In a double blind, placebo-controlled and parallel-group study, 120 participants took either 500 mg of ginger rhizome powder or placebo three times daily. The first protocol involved supplementation for 5 days (two days before the onset of the menstrual cycle and three days after) of both groups, while the second protocol involved supplementation during the first 3 days of the menstrual cycle. Ginger significantly reduced the severity of pain compared to the placebo in both the 3-day and 5-day groups, but it only reduced the duration of pain in the 5-day group. Therefore, taking ginger at least several days before and after menstruation is most beneficial.

Magnesium

In one study on the effect of magnesium or a placebo on women with dysmenorrhea, magnesium had a therapeutic effect on both back pain and lower abdominal pain on the second and the third days of the cycle. In addition, there was a marked reduction in absences from work due to the dysmenorrhea.

In another study, treatment started on the 15th day of the cycle and continued till the next menses. Although both the placebo and the magnesium treatments reduced pain associated with menstruation, those receiving magnesium had significantly less pain than the placebo group. Magnesium also improved premenstrual complaints, and the number of days the women suffered from menstrual headaches were only reduced in the magnesium group.

L-Carnitine

500 mg of L-carnitine daily for 12 weeks improved muscular symptoms such as muscle weakness, fatigue, and cramps/aches in 66% of the 30 patients studied who were undergoing hemodialysis.

 

Market Trends

NSAIDS and birth control pills are currently the main treatment for menstrual cramps and painful periods. They are reported to be very effective, although there are some risks and adverse effects linked to their long-term use. Most natural substances have not been found effective enough to relieve the debilitating pain that some women experience during their monthly cycle.

AOR Advantage

Fem Ease combines several well-known natural ingredients with novel uses for a unique formula designed to relieve menstrual pain, cramping and other physical symptoms of PMS. Use with AOR’s Fem Calm for a well-rounded combination for overall PMS and to support PMS-related mood changes.

References

Abass, M. 2012. Evaluation of Serum Magnesium , Hemoglobin and Body Mass Index in Dysmenorrheic Women in Tikrit Ciy/Iraq, Tikrit. Journal of Pure Science; 17(4): 59-62.

Allais G, Bussone G, De Lorenzo C, Mana O, Benedetto C. Advanced strategies of short-term prophylaxis in menstrual migraine: state of the art and prospects. Neurol Sci. 2005 May;26 Suppl 2:s125-9.

Berna, C., Leknes, S., Holmes, E., Edwards, R., Goodwin, G., & Tracey, I. 2010. Induction of Depressed Mood Disrupts Emotion Regulation Neurocircuitry and Enhances Pain Unpleasantness. Biological Psychiatry; 67(11): 1083-90.

Bettendorf B, Shay S, Tu F. Dysmenorrhea: contemporary perspectives. Obstet Gynecol Surv. 2008 Sep;63(9):597-603.

Chan, W. & Hill, J. 1978. Determination of Menstrual Prostaglandin Levels in Non-dysmenorrheic and Dysmenorrheic Subjects. Prostaglandins; 15(2): 365-375.

Dawood, M. 1986. Current Concepts in the Etiology and Treatment of Primary Dysmenorrhea. Acta Obstet Gynecol Scand Suppl; 138: 7–10.

Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. , & Genazzani, A.  1991. Oral Magnesium Successfully Relieves Premenstrual Mood Changes. Obstetrics & Gynecology; 78(2): 177.

Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991). Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 31:298–301

Fontana-Klaiber H, Hogg B. Therapeutic effects of magnesium in dysmenorrhea. Schweiz Rundsch Med Prax. 1990 Apr 17;79(16):491-4.

Gafner, S., Dietz, B., McPhail, K., Scott, I., Glinski, J., Russell, F., McCollom, M., Budzinski, J., Foster, B., Bergeron, C., Rhyu, M., & Bolton, J. 2006. Alkaloids from Eschscholzia californica and Their Capacity to Inhibit Binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A Receptors in vitro. J Nat rod.; 69(3): 432-435.

Ghayur, M.  & Gilani, A. 2007. Inhibitory Activity of Ginger Rhizome on Airway and Uterine Smooth Muscle Preparations. European Food Research and Technology; 224(4): 477-481.

Gollenberg, A., Hediger, M., Mumford, S., Whitcomb, B., Hovey, K., Wactawski-Wende, J., & Schisterman, E. 2010. Perceived Stress and Severity of Perimenstrual Symptoms: The BioCycle Study. Journal of Women’s Health; 19(5): 959-967.

Gulcin I. 2006. Antioxidant and Antiradical Activities of L-Carnitine. Life Science; 78: 803-811.

Jenabi, E. 2013. The effect of Ginger for Relieving of Primary Dysmenorrhoea. J Pak Med Assoc.; 63(1): 8-10.

Ju H, Jones M, Mishra G. The prevalence and risk factors of dysmenorrhea. Epidemiol Rev. 2014;36(1):104-13.

Kiuchi, F., Iwakami, S., Shibuya, M., Hanaoka, F., & Sankawa, U. 1992. Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarlherptanoids, Chem Pharm Bull.; 40(2): 387-391.

Ko, Y. , Hong, S., & Pedersen, P. 1999. Chemical Mechanism of ATP Synthase. Magnesium Plays a Pivotal Role in Formation of the Transition State Where ATP is Synthesized from ADP and Inorganic Phosphate. Journal of Biological Chemistry; 274(41): 28853-28856.

Kumar A, Purwar B, Shrivastava A, Pandey S. Effects of curcumin on the intestinal motility of albino rats. Indian J Physiol Pharmacol. 2010 Jul-Sep;54(3):284-8.

Ozgoli, G., Marjan, G., & Fariborz M. 2009. Comparison of Effects of Ginger, Mefenamic Acid, and Ibuprofen on Pain in Women with Primary Dysmenorrhea. The Journal of Alternative and Complementary Medicine; 15(2): 129-132.

Pharmacopoeia of the People’s Republic of China, 2005, Part I, Volume I, page 121.

RaO, S., & Vijyasree, M. 2011. Oxidative Stress and Antioxidant Status in Primary Dysmenorrhea. Journal of Clinical and Diagnostic Research; 5: 509-511.

Rahnama, P., Montazeri, A., Huseini, H., Kianbakht, S. & Naseri, M. 2012. Effect of Zingiber officinale R. Rhizomes (Ginger) on Pain Relief in Primary Dysmenorrhea: A Placebo Randomized Trial. BMC Complementary and Alternative Medicine; 12:92.

Rupa Vani K, Veena KS, Subitha L, Hemanth Kumar VR, Bupathy A.  Menstrual abnormalities in school going girls – are they related to dietary and exercise pattern? J Clin Diagn Res. 2013 Nov;7(11):2537-40.

Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., & Maeda, K. 1998. Effects of L-Carnitine Supplementation on Muscular Symptoms in Hemodialyzed Patients. American Journal of Kidney Diseases; 32(2): 258-264.

Spiering, B., Kraemer, W., Vingren, J., Hatfield D., Fragala M., Ho J., Maresh C., Anderson J., & Volek, J. 2007. Responses of Criterion Variables to Different Supplemental Doses of L-Carnitine L-Tartrate. The Journal of Strength & Conditioning Research; 21(1): 259-264.

Stults-Kolehmainen, M., & Bartholomew, J.  2012. Psychological Stress Impairs Short-Term Muscular Recovery from Resistance Exercise. Medicine & Science in Sports & Exercise; 44(11): 2220-2227.

Wall, B., Stephens, F., Constantin-Teodosiu, D., Marimuthu, K., Macdonald, A. & Greenhaff, P. 2011.

Yanagida, T., Arata, T., & Oosawa, F. 1985. Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle. Nature; 316 (6026):366-369.

 

Abstract

Menstrual abnormalities in school going girls – are they related to dietary and exercise pattern?

J Clin Diagn Res. 2013 Nov;7(11):2537-40.

Rupa Vani K, Veena KS, Subitha L, Hemanth Kumar VR, Bupathy A

Context: Adolescence is the transitional phase of physical and mental development between childhood and adulthood and is characterized by immense hormonal changes.75% of girls experience some problems associated with menstruation. Aim: We tried to find out the prevalence of menstrual abnormalities in school going girls in Pondicherry and their association with dietary and exercise habits.

Setting and Design: A cross-sectional questionnaire based study was conducted in adolescent girls who attained menarche in four secondary schools of Pondicherry, India.

Material and Methods: All students who attained menarche and willing to participate in the study were invited to answer the questionnaire, which dealt with anthropometric data, socioeconomic data, menstrual history, and diet and exercise pattern.

Statistical Analysis: Chi-square test and Fisher’s exact test was used to compare the dietary and exercise patterns among students having menstrual abnormalities and those who do not have menstrual abnormalities.

Results: A total of 853 students participated in the study. Dysmenorrhea and premenstrual symptoms were the most frequent problems encountered. Premenstrual symptoms were significantly more common among girls who were overweight, in girls who were eating junk food regularly, in girls who were eating less food (dieting) in order to lose weight and in those who were not doing regular physical activity. Dysmenorrhea was significantly more common in the girls who were dieting to lose weight. Passage of clots was also significantly high in the girls who were dieting.

Conclusion: Lifestyle modifications like regular physical activity, decreasing the intake of junk food and promoting healthy eating habits should be emphasised in school health education programs to improve their menstrual health.

 

The effect of ginger for relieving of primary dysmenorrhoea.

J Pak Med Assoc. 2013 Jan;63(1):8-10.

Jenabi E.

OBJECTIVE: To assess the effectiveness of ginger in providing relief to patients of primary dysmenorrhoea.

METHODS: The clinical trial was conducted at Toyserkan Azad University in western Iran from July 10 to September 5, 2010. It comprised of 70 female students of the university with primary dysmenorrhoea. The subjects were randomly divided in to two equal groups and were given either placebo or ginger in capsule form for 3 days in first menstruation cycles. They graded the severity of their pain using a visual analogue scale. A 5-point Likert scale was used to assess response to treatment. Wilcoxor’s rank-sum test was used to compare the severity of pain in the two groups.

RESULTS: Compared with the baseline, the decrease in the visual analogue scores of post-therapy pain in the ginger group was significantly greater than that for placebo group. In the ginger group, 29 (82.85%) subjects reported an improvement in nausea symptoms, compared with 16 (47.05%) in the placebo group.

CONCLUSION: Ginger is effective in minimising the pain severity in primary dysmenorrhoea.

 

Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial.

BMC Complement Altern Med. 2012 Jul 10;12:92.

Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M.

BACKGROUND: Zingiber officinale R. rhizome (ginger) is a popular spice that has traditionally been used to combat the effects of various inflammatory diseases. The aim of this study was to evaluate the effects of ginger on pain relief in primary dysmenorrhea.

METHOD: This was a randomized, controlled trial. The study was based on a sample of one hundred and twenty students with moderate or severe primary dysmenorrhea. The students were all residents of the dormitories of Shahed University. They were randomly assigned into two equal groups, one for ginger and the other for placebo in two different treatment protocols with monthly intervals. The ginger and placebo groups in both protocols received 500 mg capsules of ginger root powder or placebo three times a day. In the first protocol ginger and placebo were given two days before the onset of the menstrual period and continued through the first three days of the menstrual period. In the second protocol ginger and placebo were given only for the first three days of the menstrual period. Severity of pain was determined by a verbal multidimensional scoring system and a visual analogue scale.

RESULTS: There was no difference in the baseline characteristics of the two groups (placebo n = 46, ginger n = 56). The results of this study showed that there were significant differences in the severity of pain between ginger and placebo groups for protocol one (P = 0.015) and protocol two (P = 0.029). There was also significant difference in duration of pain between the two groups for protocol one (P = 0.017) but not for protocol two (P = 0.210).

CONCLUSION: Treatment of primary dysmenorrhea in students with ginger for 5 days had a statistically significant effect on relieving intensity and duration of pain.

 

Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.

J Altern Complement Med. 2009 Feb;15(2):129-32.

Ozgoli G, Goli M, Moattar F.

OBJECTIVES: To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.

METHODS: This was a double-blind comparative clinical trial conducted from September 2006 to February 2007. Participants were 150 students (18 years old and over) with primary dysmenorrhea from the dormitories of two medical universities who were alternately divided into three equal groups. Students in the ginger group took 250 mg capsules of ginger rhizome powder four times a day for three days from the start of their menstrual period. Members of the other groups received 250 mg mefenamic acid or 400 mg ibuprofen capsules, respectively, on the same protocol. A verbal multidimensional scoring system was used for assessing the severity of primary dysmenorrhea. Severity of disease, pain relief, and satisfaction with the treatment were compared between the groups after one menstruation.

RESULTS: There were not significant differences between groups in baseline characteristics, p > 0.05. At the end of treatment, severity of dysmenorrhea decreased in all groups and no differences were found between the groups in severity of dysmenorrhea, pain relief, or satisfaction with the treatment, p > 0.05. No severe side effects occurred.

CONCLUSION: Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea. Further studies regarding the effects of ginger on other symptoms associated with dysmenorrhea and efficacy and safety of various doses and treatment durations of ginger are warranted.

 

Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients.

Am J Kidney Dis. 1998 Aug;32(2):258-64.

Sakurauchi Y, Matsumoto Y, Shinzato T, Takai I, Nakamura Y, Sato M, Nakai S, Miwa M, Morita H, Miwa T, Amano I, Maeda K.

Various muscle symptoms are well recognized among patients on maintenance hemodialysis. Carnitine deficiency may be an important factor of dialysis-associated muscle symptoms, whereas high-dose L-carnitine supplementation may result in unphysiologically high plasma levels of carnitine and carnitine esters. We studied the effect of low-dose L-carnitine treatment (500 mg/d) on muscle symptoms, plasma carnitine fractions, and lipid profiles in 30 periodically dialyzed patients with muscular weakness, fatigue, or cramps/aches. After 12 weeks of L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms, whereas carnitine fractions were normal or slightly above normal ranges, but lipid profiles showed no demonstrable changes. This study also showed the correlation between plasma-free carnitine deficiency and months on dialysis. These results suggest that prolonged low-dose L-carnitine treatment can improve dialysis-associated muscle symptoms by restoring carnitine tissue levels and washing out acyl moieties.

 

Oral magnesium successfully relieves premenstrual mood changes.

Obstet Gynecol. 1991 Aug;78(2):177-81.

Facchinetti F, Borella P, Sances G, Fioroni L, Nappi RE, Genazzani AR.

Reduced magnesium (Mg) levels have been reported in women affected by premenstrual syndrome (PMS). To evaluate the effects of an oral Mg preparation on premenstrual symptoms, we studied, by a double-blind, randomized design, 32 women (24-39 years old) with PMS confirmed by the Moos Menstrual Distress Questionnaire. After 2 months of baseline recording, the subjects were randomly assigned to placebo or Mg for two cycles. In the next two cycles, both groups received Mg. Magnesium pyrrolidone carboxylic acid (360 mg Mg) or placebo was administered three times a day, from the 15th day of the menstrual cycle to the onset of menstrual flow. Blood samples for Mg measurement were drawn premenstrually, during the baseline period, and in the second and fourth months of treatment. The Menstrual Distress Questionnaire score of the cluster “pain” was significantly reduced during the second month in both groups, whereas Mg treatment significantly affected both the total Menstrual Distress Questionnaire score and the cluster “negative affect.” In the second month, the women assigned to treatment showed a significant increase in Mg in lymphocytes and polymorphonuclear cells, whereas no changes were observed in plasma and erythrocytes. These data indicate that Mg supplementation could represent an effective treatment of premenstrual symptoms related to mood changes.

 

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