Green Lipped FFA

AOR04228

Alleviates Inflammation Due To Osteoarthritis

  • High in rare omega-3s ETA and SDA
  • Provides better joint support than conventional fish oil
  • Green-lipped mussel extract sourced from New Zealand
Absorbable
Corn Free
Gluten Free
Non-GMO

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Green Lipped FFA contains omega-3 fatty acids from the green lipped-mussel of New Zealand, which has unique benefits for osteoarthritis and rheumatoid arthritis not seen with standard omega-3 supplements. This is due to the fact that it is high in rare omega-3s not found in most fish oil extracts: eicosatetraenoic acid (ETA) and its precursor stearidonic acid (SDA). Not all green-lipped mussel products are fatty acid extracts – many simply contain the crude dried mussel powder. AOR’s Green Lipped FFA is a concentrated fatty acid extract, making it much more potent than common dried mussel products.

Few people know that ETA and SDA are actually superior to other omega-3s at quenching the fires of inflammation such as in rheumatoid arthritis and osteoarthritis patients, giving more potent anti-inflammatory benefits at significantly lower doses. They act in similar ways to non-steroidal anti-inflammatory drugs (NSAIDs) but by multiple mechanisms of action and without the negative side effects. Additional research has found that Green Lipped FFA can provide relief for bronchial inflammation, and animal studies have suggested that it may be beneficial in premenstrual syndrome (PMS).

Green Lipped FFA is an excellent alternative to conventional fish oils for anyone who wants to address inflammation, or simply to increase their intake of omega-3 fatty acids.

NPN

80012063

Discussion

Green Lipped FFA is the stable free fatty acid mixture of the New Zealand green-lipped mussel. This compound contains a unique profile of omega-3 and other fatty acids not found in significant amounts in standard fish oil supplements. Studies show that this unique fatty acid extract with its physiological effects is more effective against inflammation than conventional fish oils.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy or eggs.

AOR Advantage

ETA/SDA-based omega-3 supplements are an orthomolecular revolution, providing powerful support against inflammation in ways that other natural supplements can’t match. The biochemistry explains the results seen in animal studies and clinical trials. AOR’s Green Lipped FFA is sourced off the coast of New Zealand. It is is a stable fatty acid extract, meaning that its anti-inflammatory benefits give results that can be relied upon. Benefit from the unique array of rare omega-3 fatty acids found in Green Lipped FFA, an excellent alternative to conventional fish oils.

Adult Dosage

Take 2 softgels twice daily for the first 2 months, followed by 1 softgel twice daily for the next 4 months, take with a fat-containing meal, or as directed by a qualified health care practitioner.

Cautions

Consult a health care practitioner for use beyond 6 months or if symptoms persist or worsen.
Do not use if pregnant or breastfeeding. This product contains soy and shellfish derived ingredients, do not use if you have such allergies.

Main Applications
  • Inflammation
  • Osteoarthritis
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: 1 Softgels
Amount Per Serving
% Daily Value
Green-Lipped Mussel fatty acid extract (Perna canaliculus)
50 mg

† Daily Value not established

Non-medical Ingredients: olive oil, D-alpha tocopherol (from soy). Softgel: gelatin (bovine), glycerin.

The Type of Fish Oil Extract Matters

While ETA is very rare in the normal Western diet, it is found in significant amounts in the fatty acids of the green-lipped mussel (Perna canaliculus). Many early studies in humans and animals found that crude extracts of Perna were effective in reducing inflammation, and in relieving the symptoms of osteoarthritis – but other studies found no effect.

The reason, as later studies confirmed, was that the anti-inflammatory properties of the green-lipped mussel were due to their content of SDA and ETA. Most green-lipped mussel supplements are not stable fatty acid extracts, but are crude concentrates or are based on mucopolysaccharides. When seven commercially-available green mussel products were put to the test by comparing them with a stable fatty extract rich in ETA and SDA, the fatty acid extract revealed strong anti-inflammatory powers, while the other extracts were found to vary wildly in strength. Great variations were even revealed in different batches of the same product.

Fatty Acids Are the Key

More tellingly, when the inflammation-fighting powers of a stable ETA- and SDA-rich extract were compared with crude P. canaliculus extracts whose fatty acid content had been deliberately removed, the fatty acid extract of the mussel exhibited potent anti-inflammatory effects, while the ETA-depleted preparation was found to be completely ineffective.

A Human Trial

In a randomized, double-blind, controlled trial involving osteoarthritis sufferers, significant improvements were reported in morning stiffness, joint tenderness and measures of joint functionality during the double-blinded phase among subjects taking the SDA/ETA-rich oil. Assessment by doctors and patients concluded that 70% of the persons with osteoarthritis had experienced a good response.

How Does It Work?

Why does the SDA- and ETA-rich oil of Perna canaliculus so remarkably outperform other omega-3s? The anti-inflammatory powers of all omega-3 fatty acids are grounded in biochemistry: the omega-3s’ ability to bind up key enzymes involved in making “bad” eicosanoids. And as studies show, ETA, and SDA working through it, more potently prevent the formation of both types of “bad” eicosanoids: series-2 prostanoids and series-4 leukotrienes. Mechanisms are believed to include:

  • A stronger ability to tie up delta-5 desaturase, the enzyme that forms arachidonic acid.
  • Indirectly increasing the production of the “good” eicosanoids from DGLA.
  • ETA’s close chemical resemblance to arachidonic acid, leading to stronger tying up of the LOX enzyme.

Multiple Anti-Inflammatory Mechanisms

In addition to these advantages, SDA and ETA share anti-inflammatory mechanisms that are common to all omega-3 fatty acids. Thus, ETA and SDA are natural COX-2 inhibitors. Remarkably, omega-3s accomplish this feat not only because their natural metabolites bind up COX-2, but also by actually working at the gene level to reduce the production of COX-2 from the DNA code. And SDA/ETA block the formation of inflammatory cytokines (immune system messenger chemicals) such as tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1). Revolutionary new painkillers – such as etanercept (Enbrel®) are so effective because they target TNF-alpha.

ETA and SDA Top the Omega-3s

Two direct comparison studies have been performed in animals to compare the anti-inflammatory effects of the ETA- and SDA-rich oil of P. canaliculus against those of salmon, cod liver, flaxseed, and two mixed fish oils. These studies clearly show that the ETA- and SDA-rich fatty acid extract of P. canaliculus is far superior to other omega-3 sources at quenching the fires of inflammation, giving more potent anti-inflammatory benefits at significantly lower doses.

Using the series of tests discussed above, rear paw swelling was reduced by 96-98% by the ETA/SDA-rich oil, while swelling was only lowered by 7 to 38% with common omega-3s! These results are all the more remarkable because the dose of ETA/SDA-rich P. canaliculus oil was only about 1% of that used for the standard omega-3 oils.

Another recent study tested the effects of these novel fatty acids in a rat model of inflammation. After 15 days of administering omega-3 fatty acid extracts from P. canaliculus, rear paw swelling was significantly reduced by 34% and fore paw inflammation by 60%. Deterioration in total body condition was reduced by 52% compared to controls. The extract also decreased inflammatory response in the spleen, and it had a 35-70% inhibition of leukotriene metabolites. Serum levels of the inflammatory biomarker ceruloplasmin were reduced compared to control mice, indicating a less severe disease state. Interestingly, the fatty acids had comparable potency to the known anti-inflammatory agent piroxicam. The fatty acid extract had no adverse side effects.

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