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Gymnema sylvestre is a woody branched vine growing in the wild forests of Central and South India. The plant has been used in traditional Ayurvedic medicine for centuries for many different conditions, but is mainly known for enhancing blood sugar metabolism. It does this by reducing glucose absorption from the intestines and increasing peripheral insulin sensitivity, and some evidence even suggests that it may support the body’s ability to produce its own insulin by helping to repair the cells in the pancreas that make it. Clinical trials have found that gymnema can lower blood glucose and decrease the need for insulin in both insulin-dependent (type 1) and insulin-independent (type 2) diabetes.
Balancing blood sugar will help not only to manage diabetes but also to reduce weight gain. When used as a mouthwash, gymnema inhibits the sensation of sweetness by interfering with the tongue's sugar receptors. Gymnema has been found to lower blood lipids in diabetic subjects and it also inhibits the growth of Candida albicans, an opportunistic fungus that is known to cause a wide array of health issues.
AOR’s Gymnema-75 is an evidence-based, high dose extract of Gymnema sylvestre. Those looking for a natural support for blood sugar management and candida control will benefit from supplementing with this ancient Indian herb.
Gymnema-75 is a high-potency extract of Gymnema sylvestre, an herb used in traditional Ayurvedic medicine to help promote digestion and manage cravings.
|Serving Size: 1 Capsule||Amount||% Daily|
|Gymnema sylvestre (20:1 leaf extract)||300 mg†|
†Contains 225 mg gymnemic acids.
Note : Herbal extracts will naturally vary in colour from one batch to another.
microcrystalline cellulose, silicon dioxide, may contain sodium stearyl fumarate. Capsule: hypromellose.
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.
Take 1 capsule daily with food, 2 hours before or after taking other medications, or as directed by a qualified health care practitioner.
Do not use if pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes, intestinal disorders or symptoms such as abdominal pain, nausea, vomiting or fever.
Gymnema sylvestre leaf
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
Gymnema sylvestre (GS), an herb belonging to the Asclepiadacea family, is a woody branched vine growing in the wild forests of Central and South India. The plant has been used by the traditional medical practitioners of India since Buddha’s era. The hypoglycemic effect of this herb was scientifically tested for the first time in 1930. It was observed that GS modulated blood glucose levels in alloxan-induced diabetic dogs but not in pancreactomized animals, suggesting that some residual pancreatic tissue is needed for this herb to be effective. Further research revealed that GS modulated blood glucose levels in both insulin-dependent and non-insulin-dependent rats with unhealthy blood sugar levels.
Since conventional treatments often support part of the problem but neglect or create others, the search for natural treatments for blood sugar control persist. In this context, the Ayurved herb Gymnema sylvestre has gained considerable importance and generated much scientific and medical interest.
Reduces Blood Glucose, HbA1c, and Medication Requirements
In human clinical trials, Gymnema extracts were effective in patients with unhealthy blood sugar levels. In 22 patients, Gymnema extract resulted in a significant reduction in blood glucose, and in sugar-modified haemoglobin and plasma proteins. 5 of the 22 patients were able to discontinue their standard medications and maintain healthy blood glucose levels with Gymnema alone.
Repairs Beta Cells in the Pancreas
Similar results were found in a study of 27 patients receiving therapy for unhealthy blood sugar levels. The Gymnema, along with its other effects, reduced the requirements for insulin and brought serum lipids to almost normal levels. The Gymnema extract appeared to enhance the body’s own insulin, possibly by regenerating or repairing beta cells which produce insulin.
Glucose Receptor Modulation
More recent studies suggest that the GS may inhibit the release of Gastro-Intestinal Peptide (G.I.P.), which normally occurs following duodenal infusion of glucose. In addition to reducing the insulinotropic action of gastro-intestinal hormones, GS is thought to increase peripheral insulin sensitivity. This might then result in lowered insulin levels during a glucose tolerance test. The mechanism of action may be via the interaction with the glucose receptor. This may explain the folklore claims of loss of sweet sensation following chewing of GS leaves. In fact, GS is considered a carbohydrate metabolism modifier and has the following properties:
(1) Sensation of taste. The tongue sugar receptors are effectively blocked by GS, thereby inhibiting sensation of sweetness.
(2) Glucose Control. Inhibition of uptake of glucose in the intestines by interacting with and blocking the glucose receptor sites, thereby reducing the “spike” in glucose and insulin seen after a meal.
The active ingredients are thought to be saponin and glycoside derivatives. So far, eleven different types have been isolated and identified as gymnemic acids. The chemical structure has been identified by nuclear magnetic resonance and X-ray studies to be similar to glycuronides.
A high dietary glycemic load, coupled with sedentary and stressful lifestyles, has contributed to the alarming number of people with unhealthy blood sugar levels. Clinical complications include cardiovascular disease, peripheral vascular disease, strokes, renal disease, arterial problems, and blindness. Managing the symptoms of unhealthy blood sugar levels can be complex and may also involve the use of medications that have negative side effects. Changes in lifestyle and dietary habits are also generally recommended in the case that one has to take medications to control their blood sugar levels.
Numerous therapeutic approaches are available and depend on individual response. Dietary restrictions and insulin administration, though effective, are not found to correct the multiple tissue defects completely. Oral hypoglycemic drugs such as sulfonylureas and biguanides are known to have serious side effects; hence, the search for hypoglycemic agents which deal with the disease more completely and with minimum possible undesirable effects still persists.
Gymnema sylvestre has a long and well recognized history in Ayurvedic medicine of being effective in lowering elevated blood sugar levels by helping to support healthy glucose metabolism. The terpenoid active molecules known as the gymnemic acids are scientifically proven to be responsible for the health benefiting mechanisms that are provided byGymnema sylvestre.
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct; 30(3): 295-300.
Okabayashi Y, Tani S, Fujisawa T, Koide M, Hasegawa H, Nakamura T, Fujii M, Otsuki M. Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats. Diabetes Res Clin Pract 1990 May-Jun; 9(2): 143-8.
Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharmacol 1990 Oct; 30(3): 265-79.
Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990 Oct; 30(3): 281-94.
Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal.
Mol Cell Biochem. 2006 May 12
Luo H, Kashiwagi A, Shibahara T, Yamada K.
Objective: The aim of this work was to find obesity control method without rebound. In our previous studies, gymnemate extracted from Gymnema sylvestre, inhibited oleic acid absorption. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a genetic multifactor syndrome model, exhibits progressive overweight, hyperlipidemia and hyperglycemia. The effect of gymnemate on obesity in OLETF was investigated.
Methods: Three groups were divided (n = 4-8): (1) OLETF-gymnemate, gymnema water extract (containing gymnemate) diet (62.5 g/kg) and water (2.5 g/kg) were supplied 2 weeks from 26-28 weeks, following it general diet and water were fed 3 weeks to observe if it rebound, (2) OLETF-control and (3) the counterpart Long-Evans Tokushima Otsuka rats as normal-control.
Results: With gymnemate treatment, the food and water intake were decreased about 1/3 and 2/3, along with body weight reduced 57.2 /- 6.4 and 75.5 /- 6.3 g during 1 and 2 weeks respectively. In the end of experiment (3 weeks after gymnemate withdrawal), the body weight was decreased to no significant difference with normal-control. The total cholesterol was decreased about 1/3, moreover LDL VLDL (low-density and very-low-density lipoprotein) cholesterol decreased about 1/2. The proportion of HDL (high-density lipoprotein) cholesterol to the total cholesterol was increased. The serum triglyceride was decreased to the 1/4 of OLETF control. The level of serum cholesterol and triglyceride was no significant difference in gymnemate group with normal group.
Conclusion: Supplementation with gymnemate promotled weight loss by its ability to reduce hyperlipidemia, which was no withdrawal rebound: an important discovery. Supplementation with gymnemate is a novel therapeutic tool for weight management, especially in multifactor syndrome.
Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats.
Diabetes Res Clin Pract 1990 May-Jun; 9(2): 143-8.
Okabayashi Y, Tani S, Fujisawa T, Koide M, Hasegawa H, Nakamura T, Fujii M, Otsuki M.
Effect of Gymnema sylvestre, R.Br. (G. sylvestre; GS4) on glucose homeostasis was studied in rats. In the first set of experiments, the acute effect of GS4 was examined in both non-diabetic and streptozocin (30 mg/kg)-induced mildly diabetic rats. Administration of 1 g/kg body weight of GS4 to 18-h fasted non-diabetic rats significantly attenuated the serum glucose response to oral administration of 1 g/kg glucose. The immunoreactive insulin (IRI) response in GS4-administered rats was lower, but not significantly, than that in control rats. In mildly diabetic rats, a 60 min increment in serum glucose concentrations was significantly reduced by GS4 administration. No IRI response was observed in these diabetic rats irrespective of GS4 administration. In the second set of experiments, the chronic effect of GS4 was examined in mildly diabetic rats. Two weeks after the induction of diabetes, the rats were divided into two groups that had similar impairment of glucose tolerance assessed by an oral glucose-loading test. The rats were fed for 32-35 days with either a control diet or a diet supplemented with GS4. After 4 weeks, GS4 showed a tendency to reduce the serum glucose concentrations in the fed state and to improve the glucose tolerance. Gain in body weight, food intake, pancreas weight and the pancreatic contents of IRI, protein, amylase and trypsinogen were unaltered in the GS4-treated group compared with the control. These results suggest...
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