Mag-K-Taurine

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Mag-K-Taurine

AOR CODE: AOR04246

Electrolytes for Nerve & Heart Function


  • Supports healthy blood pressure and regulates heart rhythm

  • Maintains the activity of nerves and muscles

  • Protects the heart from cellular damage

  • Provides a correct balance of magnesium, potassium, and taurine


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Use this product for: Heart Health Neurological Health

Details

Magnesium and potassium are electrolyte minerals that have many important functions, including maintaining the activity of nerves and muscles, regulating water retention and supporting a healthy acid-base balance. Studies suggest that 50-90% of the population is deficient in magnesium, and deficiencies in potassium often occur along with magnesium deficiencies since the minerals are closely related in function. Taurine is the most abundant free amino acid within the heart muscle and shares many of the same functions as magnesium, making it an ideal complement to the mineral.

Magnesium, potassium and taurine are essential for healthy cardiovascular function. The heart health benefits of magnesium and potassium are mostly due to their electrolyte effects on cells and nerves, supporting the ability of nerves to transmit signals and the ability of muscles to contract, both of which are important to regulate heart rhythm. A deficiency in either magnesium or potassium can result in high blood pressure, and many studies have found supplementation with either mineral to be effective for lowering blood pressure. Even mild deficiencies in potassium may result in nervous disorders, insomnia, and irregular heartbeat. Nutritional research has also proven taurine's ability to lower blood pressure, stabilize membranes and regulate the heartbeat. In repeated studies, taurine has been shown effective for regulating heartbeat, as well as for minimizing the damage caused by a lack of oxygen to the heart tissues. 

Mag-K-Taurine is ideal for those looking for a synergistic, highly absorbable mineral supplement to correct a magnesium or electrolyte deficiency. Mag-K-Taurine is especially effective in maintaining healthy blood pressure and to counterbalance an irregular heartbeat.

Label Info

Discussion

Taurine helps support cardiovascular function. Magnesium and potassium are minerals that are factors in the maintenance of good health.

Product Variation

Product Code NPN Size
AOR04246 80059998 90 VEGI-CAPS

Supplements Facts

Serving Size: 1 Capsule Amount
Magnesium (citrate) 70 mg
Potassium (chloride) 25 mg
Taurine 375 mg
Non-medical ingredients:

silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take 1 capsule four times daily with/without food, or as directed by a qualified health care practitioner. 

Cautions

Consult a health care practitioner prior to use if you are pregnant or breastfeeding. 

Source

Pharmaceutical synthesis

Main Application

Cardiovascular health

Brain function

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Research

Background

Magnesium, Potassium, and Taurine Electrolytes

Electrolytes are conductors of electricity, but they are better summarized as substances that dissociate in solution to form ions. Electrolytes, such as magnesium and potassium, have many major functions, including:

1) Impulse transmission activity – electrolytes maintain activity of nerves and muscles.

2) Help regulate water levels in the body. Shifts of fluids are controlled by electrolytes.

3) Help regulate acid-base balance.

Potassium

Potassium is a mineral that is one of the body’s many resident electrolytes. Deficiencies in potassium can be caused by magnesium deficiency, refined glucose intake, alcohol, exercise-induced water loss, dieting (decreased dietary intake), gastrointestinal losses (i.e. diarrhea), and many other dietary factors. Potassium deficiencies have become much more common today because of refined high salt diets and the increasing levels of alcohol consumption.

Low levels of potassium directly result in an electrolyte imbalance in the heart (salt concentrations in the heart muscle increase.) Even mild deficiencies in potassium may result in nervous disorders, insomnia, and irregular heartbeat. Trials have shown that even those with frequent arrhythmia found a significant drop in the likelihood of abnormal rhythms after supplementing with magnesium and potassium for three weeks. Also, potassium has a definite impact upon blood pressure. In study after study, the efficacy of using potassium supplementation for lowering blood pressure has been established.

Magnesium

When a magnesium deficiency arises, the result is high blood pressure. In a 1988 study on the prevalence of magnesium deficiency, it was reported that “Magnesium is the most under-diagnosed electrolyte abnormality…” (Whang, R: Prevalence of magnesium deficiency, Clifton, N.J., Oxford Health Care Inc., pg. 5-6). How prevalent are magnesium deficiencies? In a nationwide study conducted by the U.S. Department of Agriculture in 1977-78, only 25% of 37,785 people surveyed had magnesium intake at or greater than the RDA. That means 75% of the population was deficient!

Taurine

Taurine is the most abundant free amino acid in the blood of mammals. Within the heart muscle, taurine is again the most abundant amino acid. A variety of studies have shown taurine to be an effective modulator of heart activity, although the mechanism still has not been clarified.

Nutritional research has been gathered upon taurine’s effects on the cardiovascular system. Some of the results are astounding, especially for an unpopular (but well researched) amino acid: hypotensive activity, membrane stabilizing effects, and antiarrhythmic activity. In repeated studies, taurine has been effective in minimizing the injurious effects of congestive heart failure. A review article just published in 2012 even suggests that altered taurine exposure during fetal development can actually alter blood pressure control in adulthood.

The beneficial effects of taurine reach past the cardiovascular system: taurine protects the cellular membranes from being damaged by toxic compounds, such as oxidants, bile acids, and xenobiotics. The cellular membranes are protected by taurine because it:

1) Acts as a direct antioxidant: It protects tissues from oxidative stress because of its ability to scavenge free radicals.

2) Acts as an indirect antioxidant by preventing the disruption of ion transport and membrane permeability that results from oxidative damage. It protects the heart against free radical damage by its ability to stabilize the membranes.

 

Research

Arrhythmias

In 1994, a milestone from the Framingham Heart Study was published, linking reduced potassium and magnesium levels to premature ventricular contractions, a form of arrhythmia that can be quite lethal if not controlled properly. The Framingham Heart Study is a giant on-going cohort study that has followed the heart health of thousands of subjects since 1948 in Framingham, Massachusetts.

A subsequent 3-week study on 232 patients experiencing frequent ventricular premature beats were given 50% more magnesium and potassium than the recommended daily intake. A moderate anti-arrhythmic effect was noted. This effect was again shown in another 3 week study, and the treatment was even effective in those who were not deficient in magnesium and potassium. The treatment was most effective for patients over 50 years of age who had previous CAD or MI.

Blood Pressure Regulation

Magnesium and potassium supplementation has also been shown to be therapeutic to those with unstable blood pressure levels. In just 4 weeks, 70 mg of magnesium and 217 mg of potassium per day had beneficial effects on systolic and diastolic blood pressure by 7.83 and 3.67 mmHg respectively, improved small and large arterial compliance by 12.44% and 45.25% respectively, and decreased systemic vascular resistance by over 10%.

 

Market Trends

Most electrolyte supplements are taken in the form of energy drinks, which of course are full of sugar.

Many people supplement with magnesium only without considering the balance that magnesium strikes with potassium and taurine for nerve, muscle and heart health.

 

AOR Advantage

AOR’s Mag-K-Taurine is an electrolyte formula free of sugars that fill most electrolyte supplements. It provides an important balance of magnesium and potassium for good nerve and muscle contractility along with taurine for maintained heart function.

References

Abebe W, Mozaffari MS. Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis. 2011;1(3):293-311

Manz M, Susilo R. [Therapy of cardiac arrhythmias. Clinical significance of potassium- and magnesium aspartate in arrhythmias]. [Article in German] Fortschr Med Orig. 2002;120(1):11-5. 

Moloney MA, Casey RG, O’Donnell DH, Fitzgerald P, Thompson C, Bouchier-Hayes DJ. Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics. Diab Vasc Dis Res. 2010 Oct;7(4):300-10.

Roysommuti S, Wyss JM. Perinatal taurine exposure affects adult arterial pressure control. Amino Acids. 2012 Oct 16.

Tsuji H, Venditti FJ Jr, Evans JC, Larson MG, Levy D.The associations of levels of serum potassium and magnesium with ventricular premature complexes (the Framingham Heart Study). Am J Cardiol. 1994 Aug 1;74(3):232-5.

Wu G, Tian H, Han K, Xi Y, Yao Y, Ma A. Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension. Clin Exp Hypertens. 2006 Jul;28(5):489-97.

Zehender M, Meinertz T, Faber T, Caspary A, Jeron A, Bremm K, Just H. Antiarrhythmic effects of increasing the daily intake of magnesium and potassium in patients with frequent ventricular arrhythmias. Magnesium in Cardiac Arrhythmias (MAGICA) Investigators. J Am Coll Cardiol. 1997 Apr;29(5):1028-34.

Zhang M, Bi LF, Fang JH, Su XL, Da GL, Kuwamori T, Kagamimori S. Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids. 2004 Jun;26(3):267-71.

 

Abstract

Role of taurine in the vasculature: an overview of experimental and human studies.

Am J Cardiovasc Dis. 2011;1(3):293-311

Abebe W, Mozaffari MS.

Taurine is a sulfur-containing amino acid-like endogenous compound found in substantial amounts in mammalian tissues. It exerts a diverse array of biological effects, including cardiovascular regulation, antioxidation, modulation of ion transport, membrane stabilization, osmoregulation, modulation of neurotransmission, bile acid conjugation, hypolipidemia, antiplatelet activity and modulation of fetal development. This brief review summarizes the role of taurine in the vasculature and modulation of blood pressure, based on experimental and human studies. Oral supplementation of taurine induces antihypertensive effects in various animal models of hypertension. These effects of taurine have been shown to be both centrally and peripherally mediated. Consistent with this, taurine produces endothelium-dependent and independent relaxant effects in isolated vascular tissue preparations. Oral administration of taurine also ameliorates impairment of vascular reactivity, intimal thickening, arteriosclerosis, endothelial apoptosis, oxidative stress and inflammation, associated primarily with diabetes and, to a lesser extent with obesity, hypertension and nicotine-induced vascular adverse events. In rat aortic vascular smooth muscle cells (VSMCs), taurine acts as an antiproliferative and antioxidant agent. In endothelial cells, taurine inhibits apoptosis, inflammation, oxidative stress and cell death while increasing NO generation. Oral taurine in hypertensive human patients alleviates the symptoms of hypertension and also reverses arterial stiffness and brachial artery reactivity in type 1 diabetic patients. However, despite these favorable findings, there is a need to further establish certain aspects of the reported results and also consider addressing unresolved related issues. In addition, the molecular mechanism (s) involved in the vascular effects of taurine is largely unknown and requires further investigations. Elucidation of the mechanisms through which taurine affects the vasculature could facilitate the development of therapeutic and/or diet-based strategies to reduce the burdens of vascular diseases.

 

Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects.

Amino Acids. 2004 Jun;26(3):267-71.

Zhang M, Bi LF, Fang JH, Su XL, Da GL, Kuwamori T, Kagamimori S.

Taurine has beneficial effects on lipid metabolism in experimental animals fed with high-cholesterol or high fat diets. Whether taurine benefits lipid metabolism in humans has rarely been investigated. The aim of this study was to evaluate the effects of taurine on serum lipids in overweight or obese young adults. Thirty college students (age: 20.3 /-1.7 years) with a body mass index (BMI) >/=25.0 kg/m(2), and with no evidence of diabetes mellitus were selected and assigned to either the taurine group (n=15) or the placebo group (n=15) by double-blind randomization. Taurine 3 g/day or placebo was taken orally for 7 weeks. Triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and plasma glucose were measured before and after supplementation. The atherogenic index (AI) was calculated as (TC-HDL-C)/HDL-C. There were no differences in any baseline parameter between the two groups. Taurine supplementation decreased TG and AI significantly. Body weight also reduced significantly in the taurine group. These results suggest that taurine produces a beneficial effect on lipid metabolism and may have an important role in cardiovascular disease prevention in overweight or obese subjects.

 

[Therapy of cardiac arrhythmias. Clinical significance of potassium- and magnesium aspartate in arrhythmias]. [Article in German]

Fortschr Med Orig. 2002;120(1):11-5.

Manz M, Susilo R.

Potassium and magnesium deficiencies usually coexist and represent a risk factor for cardiac arrhythmias. Serum levels–in particular of magnesium–are inconclusive for establishing a possible electrolyte deficiency. Basic treatment of arrhythmia should therefore include the administration of potassium and magnesium, since the benefit is great, and the possible side effects is negligible. A placebo-controlled study involving patients with cardiac arrhythmias revealed that appreciably fewer ventricular asystoles occurred after three weeks of treatment with potassium and magnesium aspartate, even when serum levels were within the normal range prior to initiating treatment. Patients older than 50, and those with previous coronary heart disease and/or myocardial infarction derived particular benefit from this form of treatment. These results underscore the key role played by potassium and magnesium in the treatment of cardiac arrhythmias.

 

Antiarrhythmic effects of increasing the daily intake of magnesium and potassium in patients with frequent ventricular arrhythmias. Magnesium in Cardiac Arrhythmias (MAGICA) Investigators.

J Am Coll Cardiol. 1997 Apr;29(5):1028-34.

Zehender M, Meinertz T, Faber T, Caspary A, Jeron A, Bremm K, Just H.

OBJECTIVES: This study sought to assess potential antiarrhythmic effects of an increase in the daily oral intake of magnesium and potassium in patients with frequent ventricular arrhythmias.

BACKGROUND: Magnesium and potassium contribute essentially to the electrical stability of the heart. Despite experimental and clinical evidence for the antiarrhythmic properties of the two minerals, controlled data in patients with stable ventricular arrhythmias are lacking.

METHODS: In a randomized, double-blind study, 232 patients with frequent ventricular arrhythmias (> 720 ventricular premature beats [VPBs]/24 h) confirmed at baseline and after 1 week of placebo therapy were subsequently treated over 3 weeks with either 6 mmol of magnesium/12 mmol of potassium-DL-hydrogenaspartate daily or placebo.

RESULTS: Compared with placebo pretreatment, active therapy resulted in a median reduction of VPBs by -17.4% (p = 0.001); the suppression rate was 2.4 times greater than that in patients randomized to 3 weeks of placebo therapy (-7.4%, p = 0.038). The likelihood of a > or = 60% (predefined criterion) or > or = 70% suppression rate (calculated from the placebo-controlled run-in period) was 1.7 (25% vs. 15%, p = 0.044) and 1.5 times greater in the active than in the placebo group (20% vs. 13%, p = 0.085), respectively. No effect of magnesium and potassium administration was observed on the incidence of repetitive and supraventricular arrhythmias and clinical symptoms of the patients.

CONCLUSIONS: To our knowledge, this study is the first to provide controlled data on the antiarrhythmic effect of oral administration of magnesium and potassium salts when directed to patients with frequent and stable ventricular tachyarrhythmias. A 50% increase in the recommended minimum daily dietary intake of the two minerals for 3 weeks results in a moderate but significant antiarrhythmic effect. However, with the given therapeutic regimen, repetitive tachyarrhythmias and patient symptoms remain unchanged.

 

The associations of levels of serum potassium and magnesium with ventricular premature complexes (the Framingham Heart Study).

Am J Cardiol. 1994 Aug 1;74(3):232-5.

Tsuji H, Venditti FJ Jr, Evans JC, Larson MG, Levy D.

There are conflicting data regarding the impact of serum potassium and magnesium levels on susceptibility to ventricular premature complexes (VPCs) in the clinical setting. The associations of serum potassium and magnesium levels with the prevalence of complex or frequent (> 30/hour, multiform or repetitive) VPCs were examined after adjusting for age, sex, smoking, caffeinated coffee consumption, alcohol consumption, and left ventricular mass in Framingham Offspring Study subjects who were free of clinically apparent heart disease. There were 3,327 eligible subjects (mean age 44 years). Complex or frequent VPCs were present in 183 subjects (5.5%). When age-adjusted prevalences of complex or frequent VPCs were compared among quartiles of serum potassium and magnesium using a trend test, lower potassium (p = 0.002) and lower magnesium (p = 0.010) levels were associated with higher prevalence rates of arrhythmia. In logistic regression analyses that included potassium and magnesium simultaneously, potassium (p = 0.0021) and magnesium (p = 0.0311) levels were inversely associated with the occurrence of complex or frequent VPCs after adjustment for age, sex, smoking, coffee and alcohol consumption, diuretic use, and systolic blood pressure. These associations remained significant after accounting for left ventricular mass. A 1 SD decrement in potassium (0.48 mEq/liter) or magnesium (0.16 mEq/liter) level was associated with a 27% (95% confidence interval 6% to 51%) and a 20% (95% confidence interval 3% to 41%) greater odds of complex or frequent VPCs, respectively. Lower levels of serum potassium and magnesium were concurrently associated with higher prevalence rates of ventricular arrhythmias.

 

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