Magnesium Synergy

AOR04409

Helps maintain proper muscle function

  • Most advanced form of magnesium supplement
  • Helps in energy production and metabolism
  • Formulated to promote optimal absorption of magnesium
Gluten Free
Non-GMO
Vegan

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Magnesium Synergy is specially formulated to promote optimal absorption of magnesium into the cell, where it is needed the most, without negative side effects at therapeutic doses. This formulation helps in energy metabolism and tissue and connective tissue formation and provides electrolytes for the maintenance of good health while providing support for healthy glucose metabolism and the maintenance of healthy skin and immune function.

Magnesium Synergy is a factor in the maintenance of good health, helps the body metabolize nutrients and in the development and maintenance of cartilage, bones, and teeth. It is a source of antioxidants that helps to fight, protect cells against and reduce the oxidative effect of the oxidative damage caused by free radicals.

AOR Advantage

AOR’s Magnesium Synergy delivers a magnesium formulation that allows for optimal absorption of magnesium to provide optimal benefits for the maintenance of good health.

NPN

80079053

Discussion

Magnesium Synergy is specially formulated to promote optimal absorption of magnesium into the cell, without the negative side effects that can occur with therapeutic doses. Magnesium Synergy helps in energy metabolism and connective tissue formation, provides electrolytes for the maintenance of good health, supports healthy glucose metabolism and helps maintain healthy skin and immune function. Synergistic trace minerals are added to enhance the function of magnesium in the production of cellular energy in the mitochondria.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, or any animal byproduct.

Adult Dosage

Take one to two scoops daily, with food. Take a few hours before or after taking other medications or natural health products. Mix product well in 250-500 mL of liquid (water, juice, etc.) immediately before consumption.

Cautions

Do not use this product if you are pregnant or breastfeeding or with other supplements or salt substitutes that contain potassium. Consult a healthcare practitioner for use beyond six months. This product contains corn derived ingredients, do not use if you have an allergy.

Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: Two Scoops (6.9 g)
Magnesium (Malate)
150 mg
Elemental malic acid
817.6
Magnesium (Glycinate)
150 mg
Potassium (Aspartate)
100 mg
Chromium (Picolinate)
50 mcg
Manganese (Bisglycinate)
5 mg
Molybdenum (Na Molybdate)
100 mcg
Zinc (Malate)
15 mg
Selenium (Selenomethionine)
55 mcg
Vitamin B6 (Pyridoxal-5-Phosphate)
30 mg
Copper (Citrate)
1 mg
Glycine
600 mg
Taurine
650 mg

Non-medicinal Ingredients: sodium carbonate, citric acid, lemon flavour, maltodextrin, dextrose, acacia gum, tri calcium phosphate, monk fruit extract, dicalcium phosphate, silicon dioxide and sodium bicarbonate.

Fibromyalgia

Fibromyalgia and Magnesium Malate
A proprietary form of magnesium malate was studied in a randomized control trial for the impact of supplementation in 24 subjects with primary fibromyalgia. Subjects were given three tablets BID (providing 300 mg magnesium, and 1200 mg malic acid) for four weeks. While this did not yield any significant benefits for pain reduction. The researchers did find that benefits were seen in the extended open-label trial at a higher dose which ran for two months. Indicating that those with fibromyalgia may benefit from higher doses over a longer time rather than divided doses. This was further validated in preclinical pharmacokinetic studies describing magnesium malate absorption in rats. Whereby, magnesium malate required higher single doses rather than divided doses for optimal absorption.

Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double-blind, placebo-controlled, crossover pilot study. J Rheumatol 1995 May; 22(5): 953-8. https://pubmed.ncbi.nlm.nih.gov/8587088/

Mood

Magnesium Review in Affective Disorders

This 2002 review describes a number of studies both clinical and preclinical that describe the role of magnesium in affective disorders. Namely that the role of magnesium in prevention if hippocampal kindling and subsequently regulation of the entire HPA axis- which have a known relationship with affective disorders such as long-term depression and melancholic depression.

Murck H. Magnesium and affective disorders. Nutr Neurosci. 2002;5:375–89. https://pubmed.ncbi.nlm.nih.gov/12509067/

Another review from 2008 found much of the same however further specified mood disorders that were most significantly impacted or strongly correlated with magnesium status were those with chronic long-standing depressive symptoms rather than acute cases of depression.

Szewczyk B, Poleszak E, Sowa-Kucma M, Siwek M, Dudek D, Ryszewska-Pokrasniewicz B. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action. Pharmacol Rep. 2008;60:588–9. https://pubmed.ncbi.nlm.nih.gov/19066406/

Finding the Right Forms of Magnesium
Studies examining the absorption and pharmacokinetics of different forms of magnesium in serum and tissues provides insights into where and how long forms should be taken. Notably, magnesium taurate and glycinate were highest in tissue including the brain, while magnesium malate was acutely increased in serum. Further studies on tissue status of magnesium malate with cofactors vitamin B6 and potassium are required. In addition, it seems the best results occurred when high doses were given at the same time for long durations rather than smaller divided doses.

Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?. Biol Trace Elem Res. 2019;187(1):128‐136. doi:10.1007/s12011-018-1351-9 https://link.springer.com/article/10.1007/s12011-018-1351-9

Magnesium and B6 Combination Therapy in Individuals Suffering from Depression and Stress
This human clinical “investigator-blinded” published in 2018 examined 264 subjects who were suffering from high levels of stress (defined as Depression Anxiety Stress Scales (DASS-42) stress subscale score >18) and low serum magnesium levels (hypomagnesia defined as 0.45 mmol/L–0.85 mmol/L) but were otherwise healthy adults. The interventions were a magnesium–vitamin B6 (daily dose 300 mg and 30 mg respectively) or magnesium alone (daily dose 300 mg) for eight weeks. Outcomes included were change in DASS-42 stress subscale score from baseline as well as the incidence of adverse events (AEs). Overall both treatment arms substantially reduced DASS-42 stress subscale score from baseline to week eight (Mg–vitamin B6, 44.9%; Mg 42.4%); though they did not differ significantly. However, the analysis of participants who had severe/extremely severe stress (DASS-42 stress subscale score >25; N = 162) at baseline did exhibit a more substantial difference in improvement between groups (24% greater improvement with Mg–vitamin B6 versus Mg alone.) Further, the combination therapy group experienced fewer side effects indicating that vitamin B6 plays a significant role in magnesium utilization in cells.

Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454

Magnesium and B6 in PMS Symptom Management
This study from 2010 examined the impact of magnesium and vitamin B6 in young women suffering from premenstrual syndrome. This randomized double-blinded placebo-controlled clinical trial included women from Iran who were “15-45 years old, having a regular menstrual cycle, not affected by depression or anxiety, no acute or chronic disease, not taking medicines or supplements, and not engaging in regular exercise. After 2 cycles of tracking to ensure patients did fulfill the PMS symptom criteria, the participants were randomly assigned to one of the three groups of the study: 250 mg of Mg (n=50), 250 mg Mg plus 40 mg of vitamin B6 (n=50), and placebo. Outcomes assessed included subgroups from subjective PMS scoring systems. These subgroups included: depression (including symptoms of depression and isolation, avoiding social activities, crying, dejection, inclination to remain at home, anger, forgetfulness, insomnia, and inability to concentrate; anxiety sub-group (signs of nervous tension, irritability, and anxiety; water retention sub-group (breast pain and tenderness, lower extremity edema, bloating, and abdominal discomfort); somatic symptom sub-group (feeling cold, nausea, urination frequency, flushing, low back pain, headache, acne, greasy skin, arthralgia, and muscular pain.) Symptoms improved more prominently in the combination group that the magnesium group alone and were above the placebo.

Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):401-405. https://pubmed.ncbi.nlm.nih.gov/22069417/

Review of Potassium and Magnesium
This review from 2008 outlines the complex relationship between potassium and magnesium. Low intracellular magnesium levels increase the elimination of potassium via the due to magnesium requirement for cellular potassium absorption. A high sodium intake (standard North American diet) may further aggravate and enhance potassium excretion. A major function of potassium is to maintain the excitability of nerve and muscle tissue. Along with magnesium, potassium plays a key role in maintaining a stable and regular heart rhythm and muscle contraction while as with calcium, (both minerals are very alkalizing) they play a key role in regulating acid-base mineral balance. Unfortunately, other factors can cause these key minerals to become deficient such as chronic alcoholism, diabetes (type 2), severe vomiting and diarrhea, and medications (diuretic drugs). Therefore, if there is a magnesium deficiency (which occurs in the majority of people) an underlying deficiency in potassium might be occurring as well.

Iezhitsa IN, Spasov AA. Potassium magnesium homeostasis: physiology, pathophysiology, clinical consequences of deficiency and pharmacological correction]. Usp Fiziol Nauk. 2008 Jan- Mar;39(1):23-41. https://pubmed.ncbi.nlm.nih.gov/18314767/