Ortho Glucose II

AOR04190

Supports healthy glucose metabolism

  • Provides nutrients and herbal extracts that support healthy blood sugar levels
  • Increases insulin sensitivity
  • Reduces the risk of diabetic complications
  • AOR’s premium blood sugar balance formula
Gluten Free
Vegan

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With every meal that we eat, our bodies break down the carbohydrate portion of the meal into simple sugars, such as glucose, which can then be used for energy or stored as fat for a later time. Unfortunately, a poor diet and lifestyle can lead to poorly controlled blood sugar, impaired insulin production and eventually Type 2 Diabetes. High blood sugar or hyperglycemia is a risk factor for almost every degenerative disease, especially cardiovascular diseases. It produces inflammation, toxins and damage to the cells of the body which accelerates aging, weight gain, skin disorders and reduces life span.

Ortho Glucose II supports healthy blood sugar metabolism and may help reduce the symptoms of hyperglycemia. Hyperglycemia, or high blood sugar, increases the risk of many serious health complications including cardiovascular disease, retinal damage, blindness, neuropathy and many others. The ingredients in Ortho Glucose II have been shown to enhance the activity of insulin, improve the cellular uptake of glucose, and promote pancreatic function to produce more insulin. Ortho Glucose II also reduces the risk of complications resulting from chronic high blood sugar levels such as numbness and tingling in the fingers and toes, high cholesterol and heart disease.

AOR Advantage

Ortho Glucose II is AOR’s premium blood sugar balance formula, containing the most well-researched nutrients and plant extracts studied in diabetic subjects. They have been shown to reduce elevations in blood sugar levels, potentiate the action of insulin, improve the cellular utilization of glucose and reduce risk factors for complications associated with diabetes. Ortho Glucose II is the ideal choice for those trying to regain normal carbohydrate metabolism and striving to achieve normal blood glucose levels while protecting against the harmful effects of high blood sugar, all in one formula.

NPN

80027523

Discussion

Ortho Glucose II contains ingredients that provide support for healthy glucose metabolism. Glucose metabolism is the process which generally converts glucose into energy for cell utilization.

Guarantees

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule daily half an hour before a meal, or as directed by a qualified health care practitioner.

Cautions

Do not use if you are pregnant or breastfeeding, hypersensitive or allergic to cinnamon or Peruvian balsam, if you have acid reflux, stomach or intestinal ulcers, liver disease, alcoholism, or are taking acetaminophen. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia including feelings of anxiety, dizziness and/or confusion, tremor, sweating, paleness, chills, nausea or headache or in the case of an allergic reaction. May cause irritation of the gastric mucous membranes and reflux. Consult a health care practitioner prior to use if you have a kidney disorder, diabetes, or for use beyond six months. This product is not suitable for children. This product contains corn derived ingredients, do not use if you have an allergy.

Main Application
  • Insulin sensitivity
  • Blood sugar balance
  • Nerve function
  • Weight loss
Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Serving Size: One Capsule
Chromium (from chromium picolinate)
166 mcg
Cinnamon Cassia (Cinnamon) extract (10:1)
33 mg
Gymnema sylvestre (Gurmar) Extract (20:1)
66.5 mg
Momordica charantia (Bitter Melon) Extract (10:1)
85 mg
*R(+) alpha -Lipoic Acid (sodium salt)
100 mg

*Contains 10 mg sodium per capsule

Non-medicinal Ingredients: microcrystalline cellulose, maltodextrin, sodium benzoate, sodium stearyl fumarate.

Capsule: hypromellose

Background

Background Information

Unhealthy blood sugar levels occur when sugar levels in the blood are abnormally elevated or lowered. Many people suffer problematic symptoms as a result of high blood sugar levels. There are two types of disorders characterized by high blood sugar levels: one is insulin-dependent diabetes and the other which is non-insulin-dependent. Insulin is central to unhealthy blood sugar levels simply because it is the hormone that regulates the metabolism of glucose. Insulin regulates the entry of glucose in our cells, thereby regulating blood sugar levels. The ß cells of the pancreas produce insulin. Insulin is released when blood glucose levels rise, as is the case after a meal. Glucose is the main source of energy for our cells and without the action of insulin, there is improper glucose utilization and storage, which leads to several metabolic derangements including elevated blood sugar levels.

The incidence of unhealthy blood sugar levels is rapidly increasing and in 2008, 6% of Canadians reported were diagnosed with this health problem. The prevalence of the disease increases with age and can produce some life threatening complications such as heart disease, nerve damage in the hands and feet (neuropathy), kidney failure (nephropathy), eye damage (retinopathy, cataracts, etc.), and more.

Several well-researched nutrients have demonstrated that they can encourage healthy glucose metabolism. Ortho Glucose II is a nutritional formula that contains nutrients that encourage healthy blood sugar metabolism, support the action of insulin and protect against the complications of high blood sugar levels. These ingredients include cinnamon, chromium, bitter melon, Gymnema and R-lipoic acid.

Cinnamon

Cinnamon is a popular spice that has been known since antiquity. It is no coincidence that cinnamon is often used for the preparation of desserts. Indeed, laboratory work has demonstrated that cinnamon enhances cellular glucose uptake and utilization. Patients with unhealthy blood sugar levels often have abnormal blood lipid and cholesterol levels, which predisposes them to cardiac complications. Cinnamon has also been shown to reduce blood triglycerides and cholesterol levels. Cinnamon can therefore be used to improve blood sugar metabolism and reduce the risks of common complications associated with blood sugar level instability.

Chromium

Chromium is an essential mineral for the metabolism of carbohydrates. Chromium increases the sensitivity of insulin receptors, which increases the cellular transport of glucose and reduces blood sugar levels. Chromium supplementation has been found to lower blood glucose levels, reduce hemoglobin A1c concentrations, and improve cholesterol levels.

Momordica charantia

Momordica charantia, or MC (commonly known as bitter melon), is a fruit from the Cucurbitaceae family that is found in tropical areas throughout the world. It has been known as a ‘healing food’ in traditional circles, and in modern scientific ones the fruit extract has been studied for its potential with respect to a number of clinical applications, including microbial infections, cytotoxicity for certain types of abnormal cellular growth – and most notably – blood sugar instability.

The MC plant is exceptionally dense with micronutrients: the ones that are attributable to its hypoglycemic effects are charantin, cucurbutanoids, momordicin, oleanolic acids, and insulin-like peptide (plant (p)-insulin), the latter being structurally similar to bovine insulin.

Scientists have determined that the mechanism of action for MC extract’s ability to reduce blood sugar levels by increasing glucose utilization by the liver, inhibiting gluconeogenesis (glucose production from non-carbohydrate sources), and improving glucose oxidation.

Gymnema sylvestre

Gymnema sylvestre (GS) is an herb belonging to the Asclepiadacea family with an established history of use within the Ayurvedic tradition of medicine in India. Gymnema extract can help reduce blood sugar, HbA1c and blood lipids. Gymnema may also enhance the body’s production of insulin.

R( )- Lipoic Acid

Lipoic acid, particularly in the form of R-alpha-lipoic acid, is primarily an exceptional antioxidant which also exerts an effective glucose-metabolizing action. It can also help protect the nerves from sugar damage, which is a common complication of blood sugar instability.

Blood Sugar Disorders

In one type of blood sugar disorder, the immune system is attacking the pancreas’s insulin-producing cells. This leads to the inability to produce adequate levels of insulin and without the presence of insulin, blood sugar levels rise uncontrollably. These patients require additional insulin to regulate their blood glucose levels. Patients are typically diagnosed in childhood or early adulthood. Unfortunately, the cause remains unclear.

The other common form of blood sugar instability usually develops in late adulthood, and although insulin production may be compromised later in the course of this disorder, the condition is primarily the result of increased insulin resistance. Insulin resistance refers to the inability of our cells to respond to insulin even when normal levels of insulin are present. Once cells become insulin resistant, glucose cannot enter cells and blood glucose levels rise. Patients with this disorder are far more common, comprising 90% of patients with disorders due to blood sugar instability. This blood sugar disorder develops slowly and for which three separate stages have been identified:

Cardiovascular Complications of Unstable Blood Sugar Levels

Insulin resistance has another serious consequence; not only does it lead to elevated blood sugar levels but it also predisposes to heart disease. People with chronically elevated blood sugar levels are twice as likely to suffer from cardiovascular disease and are five times more likely to experience a heart attack. Insulin resistance gives rise to risk factors for heart disease such as lower HDL cholesterol levels (the beneficial cholesterol fraction), abdominal obesity, higher triglyceride levels and elevated low-density cholesterol (the unfavourable cholesterol fraction). Obesity is closely related to insulin resistance and is one of the main risk factors for the development of this form of blood sugar disorder. There is also a strong genetic influence on the development of blood sugar disorders with identical twins (which share the same genes) having a 90% concordance in the occurrence of the disorder.

Other frequent complications of having unstable blood sugar levels include retinal damage, blindness (this constitutes 8% of blindness cases in the US), unhealthy blood pressure levels (73% of persons with blood sugar disorders have elevated blood pressure), neuropathy (affecting 60-70% of patients with blood sugar disorders), unhealthy blood vessels, dental disease, increased susceptibility to infections, stroke, kidney failure (main cause of dialysis in developed countries) and ulcer formation, which can lead to tissue damage and amputation (one amputation every 30 seconds worldwide). In some patients, especially earlier in the disease process, exercise, dietary changes and weight loss may restore insulin sensitivity and normalize blood sugar levels. Patients that control their blood sugar levels minimize the damage to their organs (mainly kidneys, blood vessels and eyes) and their incidence of complications is significantly reduced and nearly normal.

 

Research

Cinnamon

Clinical trials have revealed that the bark of this small tree is a great choice for patients suffering from poor blood sugar control. Cinnamon improves the cellular uptake of glucose through its insulin-like activity. It also appears to reduce the gastric emptying rate, which results in lower levels of blood glucose after eating. Reported reduction of fasting plasma glucose levels varied from 10 to 29% depending on the initial glucose levels, and patients with poorly controlled blood glucose levels benefited even more from supplementation with cinnamon.

Patients affected by unhealthy blood sugar levels often have abnormal blood lipid and cholesterol levels, which predisposes them to cardiac complications. After 40 days of cinnamon supplementation, blood triglycerides and cholesterol levels were significantly reduced. A recent study showed that unhealthy subjects taking gliclazide with either 120 or 360 mg/day of cinnamon for three months had improved HbA1c and fasting blood glucose, while only the low dose group also had reduced triglycerides compared to the placebo group.

Chromium

Double-blinded, placebo-controlled studies have demonstrated that chromium supplementation lowers blood glucose levels, reduces hemoglobin A1c concentrations, and improves cholesterol levels. The most recent study showed that just 42 micrograms of chromium over 3 months reduced blood glucose from 197 to 103 mg/dL, HbA1c from 9.51 to 6.86%, and significantly reduced total cholesterol, LDL and triglycerides in newly diagnosed patients with poor blood sugar control.

Momordica charantia (Bitter melon)

In the 1970s, an insulin-like peptide from M. charantia that is structurally similar to animal insulin was found to significantly lower blood sugar in subjects with blood sugar control problems. Various MC extract have been clinically tested in these patients, and in some people, blood sugar reductions of as much as 54% have been observed after 3 weeks of MC extract supplementation. One recent study found that 2000 mg/day of a bitter melon extract significantly reduced fructosamine levels, although not quite as much as the drug metformin. However, another study showed that a bitter melon fruit extract combined with either or both common blood sugar regulation drugs metformin and glibenclamide produced a stronger hypoglycemic effect, showing synergism between the treatments.

Gymnema sylvestre

The hypoglycemic effect of this herb was scientifically tested for the first time in 1930. Further studies revealed that GS significantly lowered blood glucose levels in both insulin-dependent and non-insulin-dependent rats with poor blood sugar control. In human clinical trials, GS extracts were effective in patients with poor blood sugar control. In 22 type patients, GS extract resulted in a significant reduction in blood glucose, and in sugar-modified hemoglobin and plasma proteins. 5 of the 22 patients were able to discontinue their standard medications and maintain healthy blood glucose levels with GS alone. Similar results were found in a study of 27 patients with a similar blood sugar control disorder. The GS, along with its other effects, reduced the requirements for insulin and brought serum lipids to almost normal levels. The GS extract appeared to enhance the body’s own insulin, possibly by regenerating or repairing beta cells which produce insulin.

R( )- Lipoic Acid

Lipoic acid, particularly in the form of alpha-lipoic acid, is primarily an exceptionally versatile antioxidant which also exerts an effective glucose-metabolizing action. The latter has been demonstrated in numerous trials, including one randomized, double-blind, placebo-controlled study where 60 patients with poor blood sugar control were given at least 600 mg of alpha-lipoic acid daily and subsequently reported a 27% improvement in insulin-stimulated glucose disposal over their placebo-receiving counterparts. It is important to note that this study used alpha-lipoic acid, which is 50% comprised of the inert S(-)- enantiomer, with the effective R( )-enantiomer making up the remainder.

Another study just published tested doses of DL-alpha-lipoic acid ranging from 300 mg to 1200 mg in type II diabetic patients. Six months of supplementation showed dose-dependent decreases in fasting blood glucose and HbA1c.

 

Market Trends

Cinnamon is one of the most popular traditional blood sugar supplements. Cinnamon came to be used in desserts because of its ability to inhibit blood sugar spikes after consuming sweets. Other natural ingredients that may help reduce blood sugar include Fennugreek seeds or extract and Korean ginseng. However, larger doses are required. Studies have used doses ranging from one gram to 100 g of Fennugreek, and Korean ginseng at doses upwards of two grams per day.

References

Alpha-lipoic acid. Monograph. Altern Med Rev. 2006 Sep;11(3):232-7.

Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct; 30(3): 295-300.

Fuangchan A, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, Sirigulsatien V, Ingkaninan K, Plianbangchang P, Haines ST. Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J Ethnopharmacol. 2011 Mar 24;134(2):422-8.

Hlebowicz J, Darwich G, Bjorgell O and Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Amercian Journal of Clinical Nutrition. 2007; 85(6):1552-1556.

Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012 Jun;32(6):408-12.

Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006 May;36(5):340-4.

Momordica charantia (bitter melon). Monograph. Altern Med Rev. 2007 Dec;12(4):360-3.

Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr. 2012;21(1):12-21.

Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990 Oct; 30(3): 281-94.

Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Med Biol. 2011 Jul;25(3):149-53.

Tongia A, Tongia SK, Dave M. Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM). Indian J Physiol Pharmacol. 2004 Apr;48(2):241-4.

 

Abstract

Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects.

Am J Clin Nutr. 2007 Jun;85(6):1552-6.

Hlebowicz J, Darwiche G, Björgell O, Almér LO

BACKGROUND: Previous studies of patients with type 2 diabetes showed that cinnamon lowers fasting serum glucose, triacylglycerol, and LDL- and total cholesterol concentrations.

OBJECTIVE: We aimed to study the effect of cinnamon on the rate of gastric emptying, the postprandial blood glucose response, and satiety in healthy subjects.

DESIGN: The gastric emptying rate (GER) was measured by using standardized real-time ultrasonography. Fourteen healthy subjects were assessed by using a crossover trial. The subjects were examined after an 8-h fast if they had normal fasting blood glucose concentrations. GER was calculated as the percentage change in the antral cross-sectional area 15-90 min after ingestion of 300 g rice pudding (GER1) or 300 g rice pudding and 6 g cinnamon (GER2).

RESULTS: The median value of GER1 was 37%, and that of GER2 was 34.5%. The addition of cinnamon to the rice pudding significantly delayed gastric emptying and lowered the postprandial glucose response (P < 0.05 for both). The reduction in the postprandial blood glucose concentration was much more noticeable and pronounced than was the lowering of the GER. The effect of cinnamon on satiety was not significant.

CONCLUSIONS: The intake of 6 g cinnamon with rice pudding reduces postprandial blood glucose and delays gastric emptying without affecting satiety. Inclusion of cinnamon in the diet lowers the postprandial glucose response, a change that is at least partially explained by a delayed GER.

 

Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets.

Am-J-Clin-Nutr. 1991 Nov; 54(5): 909-16.

Anderson R A, Polansky M M, Bryden N A, Canary J J.

The effects of low-chromium diets containing chromium in the lowest quartile of normal intake on glucose tolerance and related variables in 11 females and 6 male subjects were evaluated. Subjects with glucose concentration greater than 5.56 mmol/L but less than 11.1 mmol/L 90 min after an oral-glucose challenge were designated as the hyperglycemic group and the remainder, the control group. Glucose tolerance and circulating insulin and glucagon of the hyperglycemic group all improved during chromium supplementation (200 micrograms/d) whereas those of the control group were unchanged. Glucose and insulin concentrations 60 min after the oral-glucose challenge and the sum of the 0-90 min and 0-240 min glucose values were all significantly lower after chromium supplementation in the hyperglycemic group. These data demonstrate that consumption of diets in the lowest 25% of normal chromium intake lead to detrimental effects on glucose tolerance, insulin, and glucagon in subjects with mildly impaired glucose tolerance.

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