Ortho Mind is an advanced formula for cognitive health that contains synergistic ingredients in doses supported by clinical research. These include: R-lipoic acid, acetyl-L-carnitine, Citicoline, the Ayurvedic herb Bacopa monnieri, L-pyroglutamic acid and the Asian herb Panax ginseng.
Ortho Mind is designed to support cognitive performance at any age, as well as to protect against age-related cognitive decline. R-lipoic acid and acetyl-L-carnitine work synergistically to support the function of mitochondria, where energy is produced. Since mitochondrial density is high in the brain due to its extensive energy requirements, this has the effect of increasing mental energy. R-lipoic acid is also a powerful antioxidant, protecting nerve cells from damage. Citicoline supports phospholipid and neurotransmitter synthesis, both of which support mood and brain cell function. Bacopa monnieri, an herb long revered in Ayurvedic tradition, has been shown to enhance cognitive function in both adults and children. Both bacopa and L-pyroglutamic acid have been shown to enhance learning, information processing and memory. Finally, all of the ingredients in Ortho•Mind have been clinically studied not only in healthy subjects, but in patients with cognitive impairments, all with positive results.
Ortho Mind is designed to optimize brain function in anyone from working professionals to students, aging adults who feel their mind isn’t as good as it used to be, or those who require support in a state of cognitive decline. Ortho Mind is AOR’s most comprehensive formula for superior cognitive performance.
Ortho•Mind contains ingredients that help support cognitive function and reduce mental fatigue in cases of mental stress.
|Serving Size: 6 Capsules||Amount|
|R(α)-Lipoic acid (sodium salt) †||100 mg|
|Panax ginseng extract (30:1)||100 mg|
|Bacopa monnieri extract (50% bacosides A&B)||300 mg|
|ALCAR (Acetyl-L-carnitine)||1500 mg|
|Arginine Pyroglutamate||1500 mg|
|Pantothenic acid (calcium D-pantothenate)||460 mg|
†Contains 11 mg sodium per serving.
*Cognizin® is a registered trademark of Kyowa Hakko Bio Co., Ltd.
|Non-medical ingredients: |
microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish or shellfish.
Take 2 capsules three times daily without food, or as directed by a qualified health care practitioner. Consult a health care practitioner for use beyond 2 months or for use beyond 6 weeks if you have a cardiovascular condition.
Do not use if you are pregnant or breastfeeding, have had a heart attack/myocardial infarction or have primary systemic L-carnitine deficiency or secondary L-carnitine deficiency (inborn errors of metabolism) for which supplementation is prescribed/monitored by a health care practitioner. Consult a health care practitioner prior to use if you have celiac disease, fat malabsorption, vitamin A, D, or E deficiency, diabetes, if you have cardiovascular disease and are attempting to increase physical activity, have renal/kidney disease, are following a low protein diet or are taking blood thinners, digoxin, antidepressant medications, or medications for cardiovascular diseases or erectile dysfunction. Consult a health care practitioner if your cardiovascular condition worsens. Some people may experience gastrointestinal discomfort (such as diarrhea). Some people may experience insomnia, anxiety, or headaches, in which case, discontinue use. May cause nausea, dry mouth, fatigue, and hypersensitivity (allergy). Use with caution if you have allergies to members of the Scrophulariaceae (figwort) family. If you experience sweating, paleness, chills, headaches, dizziness and/or confusion, discontinue use and consult a health care practitioner as these may be symptoms of serious low blood sugar.
Natural botanical extracts
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
Advanced Cognitive Support
To support optimal brain structure and function, a cognitive enhancement formula must:
• Facilitate energy production in the brain
• Support the clean, efficient burning of energy in the mitochondria (cellular “power plants”)
• Protect the cells of the brain from the toxic insults, whether from without, or from within (in the form of the free radicals which are the byproducts of cellular energy production)
• Maintain or restore neural cell membrane phospholipids, crucial for cellular communication
• Support optimal levels of key nerve cell messenger-molecules (neurotransmitters)
Ortho•Mind is that formula.
R-Lipoic Acid is a key mitochondrial metabolite, needed by these cellular “power plants” to drive nerve cell metabolism. R-Lipoic Acid is the natural, mitochondrial form of this critical orthomolecule – not to be confused with the artificial “racemic compound” sold as “lipoic acid” or “alpha-lipoic acid.” R-Lipoic Acid improves the efficiency of mitochondrial function, while preventing the age-related increase in free radical production which is exacerbated when ALCAR is taken alone. Since lipoic acid enhances mitochondrial function and mitochondrial dysfunction has been associated with Alzheimer’s disease and other types of cognitive decline, many researchers suggest the use of lipoic acid for cognitive health. R-Lipoic Acid has also been shown to reverse the age-related buildup of iron in the brain of laboratory animals – a buildup associated with human neurological disorders. The dose found in Ortho•Mind is designed to “top up” the amount found in a core R-Lipoic Acid supplement used for general health and anti-aging goals.
Carnitine is an amino acid that helps shuttle fatty acids into the mitochondria to produce energy. ALCAR is an acetylated form of carnitine, which allows it to cross the blood-brain barrier more effectively. ALCAR has been found to slow the cognitive deterioration and improve mental function. Numerous controlled clinical trials attest to its use in a variety of cognitive disorders and in brain function in young, healthy adults. ALCAR has also shown to be useful in improving energy and mental function in the healthy elderly, in chronic fatigue, and in stroke rehabilitation. There is also research suggesting that N-acetyl levocarnitine enhances Nerve Growth Factor (NGF), a protein that stimulates the growth of nerve cells. ALCAR is best when combined with Lipoic Acid.
L-Pyroglutamic Acid from L-Arginine-L-Pyroglutamic Acid, is the so-called “forgotten amino acid,” and is the natural molecule behind the nootropic drugs, such as piracetam, oxiracetam, and pramiracetam: these drugs are chemically “tweaked” versions of L-Pyroglutamic Acid. No one quite understands how L-Pyroglutamic Acid or the nootropics work: they don’t seem to significantly affect neurotransmitter levels, they don’t bind to any known receptors, and their metabolism is extremely simple, nontoxic, and “clean.”
But however they work, the nootropics’ ability to improve learning, memory consolidation, and retrieval in normal, healthy people has been well-established in clinical trials. Piracetam, which is the most widely-researched of these “smart drugs,” has also been found effective in dyslexia, although results in Down’s syndrome and Alzheimer’s disease have been inconclusive. One of the most interesting effects reported with piracetam, and believed to be universal to the nootropics, is its ability to facilitate communication between the left (verbal/logical) and right (spatial/ mathematical/creative) hemispheres of the brain. Subjectively, many users report that L-Pyroglutamic Acid and the nootropics “wake up your brain,” although the effect is quite distinct from that of stimulants such as caffeine.
Despite the sound of the name, L-Pyroglutamic Acid is not a potential “excitotoxin” like glutamate. Studies in laboratory animals have not only shown that feeding large doses of this nutrient to newborn mice are harmless, but that direct injection of L-Pyroglutamic Acid into the adult brain causes no negative effects. In fact, an animal experiment demonstrated that L-Pyroglutamic Acid actually protects the brain from glutamate excitotoxicity!
Citicoline (cytidine diphosphate choline) is not just a source of choline, the main building block of the neurotransmitter acetylcholine. Instead, Citicoline is a brain phospholipid booster. Phospholipids such as phosphatidylcholine (PC) and phosphatidylserine (PS) are essential components of neural membranes, and their presence is needed for the normal responsiveness of the brain to neurotransmitter signals. Taking individual phospholipids, such as PS, forces more of the specific phospholipid that you’re taking into the membranes of nerve and other cells. But it cannot restore the youthful balance of all brain phospholipids. By contrast, Citicoline enhances the brain’s ability to synthesize its own phospholipids. As a result, studies in experimental animals show that Citicoline increases levels of all phospholipids in neural membranes – yet the normal, youthful proportions of the various phospholipids are not altered. Citicoline also increases the manufacture or release of key neurotransmitters, including acetylcholine, norepinephrine, dopamine, and serotonin.
Bacopa monnieri, an herb long revered in Ayurvedic tradition, has been used to “open the gateway of intelligence” in infants, and many of the studies documenting its cognitive-enhancing powers have been conducted in school children. Studies have also shown it to be helpful in relieving anxiety.
Recently, studies have begun to give us some exciting clues about the potential long-term, neuroprotective effects of this Ayurvedic secret. A recent animal study revealed that Bacopa boosts the brain’s production of the key protective antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT).
Despite what you might hear, you can’t boost levels of SOD or CAT by taking them as preformed supplements: even when taken sublingually, these enzymes are destroyed by other enzymes. One of the few things that can rev up the brain’s production of these enzymes is the Parkinson’s drug deprenyl (Eldepryl®); this jump in SOD and CAT has been associated – in a series of remarkable experiments in mice, rats, hamsters, and dogs – with remarkable jumps in lifespan. In the most dramatic of these experiments, deprenyl actually extended the built-in maximum lifespan of lab rats by as much as 24% – a feat unprecedented by any other drug or nutrient.
But the results of other studies show that the effect is inconsistent. The success or failure of deprenyl in extending life seems to be closely associated with whether the drug boosts CAT and SOD in these organisms under the conditions of a given study. So it’s especially encouraging that the effects of Bacopa on these enzymes were shown to be even more broad-ranging than those of deprenyl, affecting a wider range of areas in the brain, and simultaneously boosting levels of the detoxifying glutathione peroxidase (GSH-Px) enzyme – an effect not seen with deprenyl.
Lastly, Panax ginseng is very well known for its cognitive boosting powers. Furthermore, the combination of Panax ginseng with ginkgo has been shown to be especially effective.
R-Lipoic acid has been the subject of many studies in animal models of Alzheimer’s disease, many of these combining it with acetyl-L-carnitine. Double-blind placebo controlled randomized clinical trials for lipoic acid in dementia are lacking despite the positive animal research.
One open label study followed up with 48 dementia patients who had received 600 mg of lipoic acid per day for 2 years. Compared to other long-term studies following up patients not receiving any treatment or those receiving certain medications, the cognitive deterioration was much lower with lipoic acid. The authors suggest an urgent phase II clinical trial.
In an early double-blind, placebo-controlled study of 130 patients clinically diagnosed with Alzheimer’s disease receiving ALCAR, a slower rate of deterioration was observed in 13 of 14 outcome measures at the end of the one-year study. These measures included intelligence, long-term verbal memory and selective attention.
A study on 1.5g of ALCAR supplementation in young adult subjects aged 22-27 for 1 month found that test subjects had better reflexes than controls to an auditory stimulus, and test subjects also demonstrated 3-4 times greater efficiency in navigating a video-game maze than controls.
In one randomized, double-blind, placebo-controlled trial, 40 men and women with age-associated memory impairment were first run through a series of memory tests, and then took either a supplement providing 1276 milligrams of L-Pyroglutamic Acid or a look-alike pill for sixty days. At the end of the study, people taking L-Pyroglutamic Acid experienced a 37.8% improvement in their ability to remember words after a twenty-minute pause; a 17% jump in immediate recall of categorized words; a corresponding 30% boost in recall of those same words after a delay; and a 50% lower rate of “false positives” (wrongly “recognizing” faces that they had never seen before). People getting the placebo experienced no improvements.
Controlled human studies prove that Citicoline provides effective nutritional support in a wide range of cognitive disorders, including Alzheimer’s disease, stroke, dementia associated with Parkinson’s disease, and head trauma. Double-blind, placebo-controlled trials have also shown that Citicoline significantly improves memory function in persons with “normal” age-related cognitive decline. These trials have used daily Citicoline doses of 300 milligrams and up.
The latest and best study on the brain-boosting powers of Bacopa has given the herb its strongest scientific endorsement yet. In this double-blind, placebo-controlled study, 46 healthy men and women took a battery of neuropsychological tests before the trial began. Then, Australian scientists provided half of them a daily supplement containing 300 milligrams of standardized Bacopa extract, while the remaining 23 people took placebos.
At the end of the twelve-week study, men and women supplementing with Bacopa showed significant improvements in cognitive function compared to the group taking the placebo pill, processing visual information 15% faster (as measured by the inspection time (IT) test), showing a 14% greater rate of learning – and a 33% lower rate of forgetting – verbal information, and a remarkable 108% better ability to consolidate new information without interference from previously-learned data (the problem of “proactive interference”). Few side effects were seen in the study, the most notable being increases in thirst and urination. Interestingly, in fact, the people taking Bacopa actually suffered fewer headaches than did those getting the dummy pills!
In one study including 97 Alzheimer’s patients it was found that taking 4.5g of ginseng powder for 12 weeks significantly improved cognitive function in the patients. The improvement deteriorated after supplementation was stopped.
In one study healthy middle-aged individuals were given 60mg of Ginkgo along with 100mg of Panax ginseng for 14 weeks. The Ginkgo/ginseng combination was found to significantly improve an Index of Memory Quality, supporting the results of previous studies. This effect represented an average improvement of 7.5% and reflected improvements to a number of different aspects of memory, including working and long-term memory.
When thinking of natural supplements for brain health, Ginkgo biloba is one of the first to come to mind. While Ginkgo is an excellent choice for delivering more nutrients to the brain, why not combine it with clinically studied nutrients shown to enhance cognitive performance and protect the brain!
If you want to get results with a cognitive support supplement – or any other supplement or drug – it’s critical to ensure that you’re getting the right dose. Far too few “kitchen sink” nutritional formulas throw in small, meaningless doses of various ingredients just so that they can list the nutrient in question on their labels.
Clinical trials are the “magnetic pole” that can guide us to the effective doses of a given nutrient. But combination cognitive support formulas present unique dosing challenges. Many “smart drugs,” botanicals, and nutrients display an “inverted ‘U’ response curve:” enough is enough, too little is too little – and too much is too much. Taking excessive amounts of cognitive-enhancing supplements, in other words, can actually be more counterproductive than taking a “just right” dose! And since these nutrients and botanicals also interact in hard-to-predict synergy, the optimal dose for a given supplement taken alone can be excessive when combined with synergistic partners.
Ortho•Mind is AOR’s principal cognitive function formula backed by clinical research. It is designed to help any brain perform better and to provide support against age-related cognitive deterioration. See the related products section for complementary products that can be combined with Ortho•Mind for superior results.
The Best Dose For You
Each individual must titrate his or her dose of cognition-enhancing nutrients to his or her own optimal level. Ortho•Mind is formulated with amounts of each individual nutrient which are at the low end of the spectrum of doses proven to be effective in controlled clinical trials. But for most people, the full six capsules will be too much, leaving them on the falling side of the inverted “U.” So it’s best to start low – one or two capsules a day – and build slow, adding one capsule every three days or so, using subjective experience and (if possible) objective tests to guide you to your personal peak in mental performance. For most people, this will be two to four capsules a day.
Alvarez XA, Laredo M, Corzo D, Fernandez-Novoa L, Mouzo R, Perea JE, Daniele D, Cacabelos R. “Citicoline improves memory performance in elderly subjects.” Methods Find Exp Clin Pharmacol. 1997 Apr; 19(3): 201-10.
Grioli S, Lomeo C, Quattropani MC, Spignoli G, Villardita C. “Pyroglutamic acid improves the age associated memory impairment.” Fundam Clin Pharmacol. 1990; 4(2):169-73.
Hager K, Marahrens A, Kenklies M, Riederer P, Munch G. “Alpha-lipoic acid as a new treatment option for Azheimer type dementia.” Arch Gerontol Geriatr 2001 Jun; 32(3):
Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. “Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid.” PNAS. 2002 Feb 19; 99(4): 2356-61.
Montgomery SA, Thal LJ, Amrein R. “Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease.” Int Clin Psychopharmacol 2003 Mar; 18(2): 61-71.
Psychopharmacology (Berl). 2001 Aug; 156(4): 481-4.
Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. “The chronic effects of an extract of Bacopa monnieri (Brahmi) on cognitive function in healthy human subjects.”
Wesnes KA et al. The memory enhancing effects of a Ginkgo bilboa/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology, Vol 152(4), Nov 2000, 353-361.
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
Neurochem Res. 2008 Jan;33(1):194-203.
We have identified a group of nutrients that can directly or indirectly protect mitochondria from oxidative damage and improve mitochondrial function and named them “mitochondrial nutrients”. The direct protection includes preventing the generation of oxidants, scavenging free radicals or inhibiting oxidant reactivity, and elevating cofactors of defective mitochondrial enzymes with increased Michaelis-Menten constant to stimulate enzyme activity, and also protect enzymes from further oxidation, and the indirect protection includes repairing oxidative damage by enhancing antioxidant defense systems either through activation of phase 2 enzymes or through increase in mitochondrial biogenesis. In this review, we take alpha-lipoic acid (LA) as an example of mitochondrial nutrients by summarizing the protective effects and possible mechanisms of LA and its derivatives on age-associated cognitive and mitochondrial dysfunction of the brain. LA and its derivatives improve the age-associated decline of memory, improve mitochondrial structure and function, inhibit the age-associated increase of oxidative damage, elevate the levels of antioxidants, and restore the activity of key enzymes. In addition, co-administration of LA with other mitochondrial nutrients, such as acetyl-L-carnitine and coenzyme Q10, appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction. Therefore, administrating mitochondrial nutrients, such as LA and its derivatives in combination with other mitochondrial nutrients to aged people and patients suffering from neurodegenerative diseases, may be an effective strategy for improving mitochondrial and cognitive dysfunction.
The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.
Psychopharmacology (Berl) 2001 Aug; 156(4): 481-4.
Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ.
RATIONALE: Extracts of Bacopa monniera have been reported to exert cognitive enhancing effects in animals. However, the effects on human cognition are inconclusive.
OBJECTIVE: The current study examined the chronic effects of an extract of B. monniera (Keenmind) on cognitive function in healthy human subjects.
METHODS: The study was a double-blind placebo-controlled independent-group design in which subjects were randomly allocated to one of two treatment conditions, B. monniera (300 mg) or placebo. Neuropsychological testing was conducted pre-(baseline) and at 5 and 12 weeks post drug administration.
RESULTS: B. monniera significantly improved speed of visual information processing measured by the IT task, learning rate and memory consolidation measured by the AVLT
CONCLUSIONS: These findings suggest that B. monniera may improve higher order cognitive processes that are critically dependent on the input of information from our environment such as learning and memory.
Citicoline improves memory performance in elderly subjects.
Methods Find Exp Clin Pharmacol 1997 Apr; 19(3): 201-10.
Alvarez XA, Laredo M, Corzo D, Fernandez-Novoa L, Mouzo R, Perea JE, Daniele D, Cacabelos R.
Citicoline is a choline donor involved in the biosynthesis of brain phospholipids and acetylcholine extensively used in the treatment of neurodegenerative diseases. In this study we investigated the effects of the oral administration of citicoline alone (C1000:1000 mg/day; C500:500 mg/day) or in combination with nimodipine (C NI:300 90 mg/day) during 4 weeks on memory performance in elderly subjects with memory deficits and without dementia (N = 24; age = 66.12 /- 10.78 years; MMS score = 31.69 /- 2.76). Results indicated that citicoline in comparison with placebo improves memory in free recall tasks, but not in recognition tests. A significant improvement in word recall (5.17 /- 1.1 vs. 3.95 /- 1.2 omissions; p < 0.005), immediate object recall (6.5 /- 1.6 vs. 5.5 /- 1.2 omission; p < 0.05) and delayed object recall (8.5 /- 2.1 vs. 6.7 /- 2.4 omissions; p < 0.005) was observed after citicoline treatment. Similar results were found in the three subgroups of treatment (8 subjects per group), suggesting that citicoline possesses memory-enhancing activity at doses of 300-1000 mg/day. A decrease in systolic blood pressure and minor changes in lymphocyte cell counting were also observed in old subjects after receiving citicoline. These effects are consistent with the vasoregulatory and neuroimmune actions of citicoline and suggest that this compound may improve memory by acting on mechanisms of brain neurotropism and cerebrovascular regulation. According to the present results, showing that citicoline improves memory performance in elderly subjects, we concluded that this molecule is suitable for the treatment of memory deficits in old people.
Pyroglutamic acid improves the age associated memory impairment.
Fundam Clin Pharmacol 1990; 4(2): 169-73.
Grioli S, Lomeo C, Quattropani MC, Spignoli G, Villardita C.
Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatm0ent by means of a battery made up of 6 memory tasks. The results suggest that PCA is effective in improving some verbal memory functions in subjects affected by age-related memory decline.
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