Pro 5 – HTP 100


Supports positive mood

  • Helps to reduce frequency of migraines
  • Enhances quality of sleep
  • Supports weight management
  • Boosts serotonin levels
Gluten Free

Pro 5-HTP 100 is L-5-hydroxytryptophan, a metabolite of the amino acid tryptophan, derived from Griffonia simplicifolia seed extract. 5-HTP is an essential precursor of the neurotransmitter serotonin and therefore is primarily used to support mood. Serotonin is also a precursor to melatonin, which can enhance sleep quality and regulate the circadian cycle. Additionally, research
supports a role for 5-HTP in reducing migraines and the symptoms of fibromyalgia.

While supplemental serotonin cannot cross the blood-brain barrier (BBB), naturally derived 5-HTP is well absorbed orally (70%) and penetrates the BBB, where it is converted into serotonin.

AOR Advantage

Pro 5-HTP 100 is an essential precursor of the neurotransmitter serotonin used to support mood and enhance sleep quality.




5-HTP 100 is 5-hydroxytryptophan, a metabolite of tryptophan and an essential precursor of serotonin and melatonin. Research supports a role for 5-HTP in supporting mood balance and relieving the symptoms of fibromyalgia. AOR’s 5-HTP is naturally- sourced from the seeds of the griffonia shrub.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage

Take one capsule three times daily with food, or as directed by a qualified health care practitioner. To minimize gastrointestinal side effect risk, slowly increase dose over a two week period. Use for a minimum of one week to see beneficial effects for mood balance and two weeks for the alleviation of fibromyalgia symptoms. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.


Do not use if you have scleroderma, if you are pregnant, breastfeeding, or trying to conceive. Not to be used by individuals under the age of 18 or those with a medical condition. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year. Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity, including, but not limited to, L-tryptophan, SAMe, St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea medication or anti-migraine medication. Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting and abdominal pain. May cause drowsiness; exercise caution if driving or operating heavy machinery or engaging in activities requiring mental alertness. Discontinue use and consult a health care practitioner if you experience skin changes, weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain.


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with a health care practitioner if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Main Applications
  • Mood
  • Fibromyalgia
  • Insomnia
  • Migraine headache
  • Weight management
Serving Size: One Capsule
L-5-Hydroxytryptophan (griffonia seed extract)
100 mg

Non-medicinal ingredients: microcrystalline cellulose, sodium stearyl fumarate.

Capsule: hypromellose.

Low levels of serotonin have been associated with multiple conditions such as anxiety, insomnia, aggressiveness, migraine headaches, and fibromyalgia, but most notably, depression.

Although supplemental serotonin does not have the ability to cross the blood-brain barrier (BBB), 5-HTP can, where it can then be converted into serotonin. Since serotonin is also a precursor to melatonin, supplementation can also help with sleep function.


Multiple studies have evaluated the clinical effects of 5-HTP. One study found that 300 mg daily led to similar yet slightly superior improvements in depressive symptoms compared to the SSRI drug fluvoxamine.1

Chronic Headaches

Research suggests a link between migraines and low serotonin levels that may be due to dysfunctional serotonin production or serotonin release/uptake from platelets and lymphocytes. Serotonin also plays an important role in mediating the descending pain inhibitory systems.

In one double-blind crossover study, patients with chronic primary headache given 400 mg of L-5-HTP daily for two months had a greater reduction in the severity and frequency of headaches compared to the placebo group.2


Women with fibromyalgia seem to have low serotonin levels and have shown symptomatic improvement with the use of tricyclic and SSRI antidepressants. Several clinical trials of 5-HTP supplementation have confirmed significant improvement in symptoms. Daily doses of 300 mg for 30 days have resulted in significant improvements in number of tender points, pain severity, morning stiffness, and ratings of sleep, anxiety and fatigue.1


Birdsall, T.C. 5-hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug; 3(4): 271-80

De Benedittis, G. and Massei, R. Serotonin precursors in chronic primary headache. A double-blind crossover study with L-5-hydroxytriptophan vs. placebo. J Neurosurg Sci. 1985 Jul-Sep; 29(3): 239-48

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