EN | FR
Pro Destress is a fast-acting and long-lasting anxiolytic for anxiety, stress, and onset insomnia, particularly in those that dealing with phase II adrenal dysfunction. It works to calm excess sympathetic tone with GABA, L-theanine, and the adaptogen holy basil.
Holy basil helps induce relaxation, promotes a feeling of calm, and reduces stress, both acutely and addressing underlying dysfunction. L-theanine is the amino acid predominately found in green tea associated with increased alpha wave activity in the brain, resulting in a calming, yet alert effect. Finally, GABA is a well-understood inhibitory neurotransmitter, prescribed in the treatment of multiple nervous system disorders, including, stress, anxiety, panic disorders, and insomnia.
Pro Destress is formulated with effective doses of L-theanine, holy basil, and GABA. This fast-acting combination is also a non-drowsy formula, making it a suitable solution for both daytime or nighttime use.
Pro Destress helps promote relaxation, and is used in herbal medicine as an adaptogen. It helps to increase energy and resistance in case of mental and physical fatigue related to stress.
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by-product.
Take one capsule daily with or without food, or as directed by a qualified health care practitioner.
Do not use if you are pregnant. Consult a health care practitioner prior to use if you are breastfeeding, taking any heart or blood pressure medication, have a heart condition or diabetes, or if symptoms persist or worsen.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with a health care practitioner if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate, hyprolose, silicon dioxide, maltodextrin.
The stress response, activating the hypothalamic-pituitary-adrenal axis (HPA), is an essential adaptive survival mechanism, designed to rapidly provide the necessary energy, strength, and stamina to handle acute stressors. In present-day society, this short-term response can become chronic, due to perceived physical and psychological threats.
With long-term activation, the HPA axis can become dysfunctional, leading to alterations in cortisol rhythms and poor adrenal output, commonly known as “adrenal fatigue”. Furthermore, dysregulation of neurobiological pathways occurs as GABA, endogenous opioids, and serotonin become depleted. These neurochemical changes are responsible for common symptoms associated with chronic stress, including fatigue, anxiety, irritability, sleeping disorders, emotional instability, and concentration problems.
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter with anxiolytic effects. Impairments in GABA-mediated inhibition are seen in various neurological and psychological conditions, such as insomnia and anxiety disorders. Recent studies have demonstrated GABA’s anxiolytic effects on the CNS by modulating the vagus nerve and gut microbiota.
L-theanine, an amino acid predominantly found in green tea, has a number of neuroregulatory effects, able to combat both acute and long-term stress. It has been shown to reduce symptoms of anxiety, improving the ratio between alpha and beta brain waves and block glutamate receptors to dampen excitatory signalling.
Holy Basil, a common Ayurvedic herb, possesses a range of actions, including adaptogenic, antioxidant and anti-inflammatory properties. The use of adaptogens provides significant relief from both acute and chronic effects of chronic HPA dysregulation seen with stress. Notably, Holy Basil can act as a neuroprotectant, able to prevent the oxidative damage associated with glucose spikes and dysglycemia.
Mechanisms of Action
Although recent evidence has identified and confirmed the presence of a GABA transporter in the blood-brain-barrier (BBB), GABA receptors are expressed in a variety of peripheral tissues, including the digestive tract.
L-theanine is an amino acid with neuroregulatory effects. Due to its similar structure to glutamate, theanine is able to modulate NMDA receptors to prevent overstimulation of the excitatory glutamate pathway. In addition, theanine increases GABA, dopamine, and glycine and reduces serotonin, lending a focused, yet calm effect.
Numerous active constituents of Holy Basil have been identified, including; eugenol, ursolic acid, rosmarinic acid and luteolin. Of these, eugenol has received considerable attention for its ability to reduce serum glucose, triglycerides, and cholesterol levels. Extracts of Holy Basil have also been shown to increase the production of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), to inhibits neuronal death, lipid peroxidation and DNA damage associated with stress-induced oxidative stress.
In a study of eight 12-year-old boys diagnosed with attention deficit/hyperactivity disorder (ADHD), consuming 200 mg of L-theanine twice daily led to significant improvements in sleep efficiency (percentage of the night spent sleeping restfully).
Holy Basil has been reported to promote relaxation, improve anxiety and symptoms of stress. One study showed that participants given 500 mg of Holy Basil, twice daily for 2 months led to significantly improved symptoms of stress (27.5%), depression (30.5%) and generalized anxiety (34.2%). Additionally, animal studies have demonstrated that Holy Basil reduces serum concentrations of cortisol and glucose, prevents lipid peroxidation associated with dysglycemia, and prevents stress-induced reductions in hippocampal acetylcholine, which are attributed to short-term memory loss during chronic stress.