Pro Estro Support


Supports estrogen metabolism and liver function

  • Promotes healthy menstrual cycles
  • Helps to balance estrogen levels
  • Promotes detoxification of toxins and excess estrogen
  • Reduces risk of abnormal cell growth
  • Lowers the risk of estrogen-related diseases


Gluten Free

Pro Estro Support provides comprehensive support for estrogen metabolism and liver detoxification. This superior formula contains D-glucarate, DIM (3,3’-diindolylmethane), hops extract, choline, and sulforaphane glucosinolate from broccoli extract.

Pro Estro Support reduces the risk of abnormal cellular growth related to estrogen. DIM supports healthy cervical tissue growth. 8PN is a phytoestrogen found in hops shown to reduce abnormal cell growth in breast tissue and interfere with undesirable estrogenic activity. D-glucarate, choline and SGS all support the detoxification of excess or inactivated estrogens.

Additionally, toxins and unbalanced estrogen metabolism are believed to increase the risk of other conditions such as uterine fibroids, menorrhagia, and endometriosis. Pro Estro Support can help support healthy, regular menstruation due to its estrogen-modulating activities.

AOR Advantage

Pro Estro Support offers a formula composed of research-based components that encourages the balance of female hormones, supporting healthy estrogen metabolism and the detoxification of excess estrogen metabolites.




Pro Estro Support contains hops and choline. Hops are traditionally used in herbal medicine as a calmative to help relieve nervousness, and Choline is a nutrient that supports liver function. Optimal liver function is essential for hormonal health.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.


Adult Dosage

Take two capsules daily with breakfast, or as directed by a qualified health care practitioner.


If you have symptoms of low estrogen (such as joint pain, mood changes, change in libido, hot flashes, night sweats, vaginal dryness or irregular menstruation); consul a health care practitioner. Consult a health care practitioner prior to use if you are taking blood thinners or natural health products. May temporarily alter urine color, consult a health care practitioner if urine does not normalize upon discontinued use. If sleeplessness (insomnia) occurs for more than four weeks, if you develop liver related symptoms (e.g., yellowing of the eyes or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen, discontinue use and consult a health care practitioner. To exclude the diagnosis of a serious hormonal imbalance, consult a health practitioner prior use.


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with a health care practitioner if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Main Applications

• Estrogen dominance
• Fibroids
• Endometriosis
• Menorrhagia
• Cervical health
• Breast cancer prevention

Serving Size: Two Capsules
LIFENOL®† Hops extract
120 mg
Calcium D-glucarate
150 mg
DIM (3,3’-diindolylmethane)
108 mg
Choline (bitartrate)
Broccoli extract
300 mg

†LIFENOL® is a registered trademark of Naturex, Inc.

Non-medicinal Ingredients: Microcrystalline cellulose, silicon dioxide
Capsule: hypromellose

Estrogen has long been considered a risk factor for a variety of women’s cancers, especially breast cancer. Research has shown that there are several types of estrogen metabolites that may increase or decrease the risk of female hormone health events. For example, 16α-hydroxylated estrogen metabolites are associated with an increased risk of breast cancer. The ingredients in Pro Estro Support work together to promote a healthy estrogen balance and to promote the detoxification of potentially harmful metabolites, thereby helping to reduce the risk of women’s cancers.


Through glucuronidation, toxic substances, environmental carcinogens and excess levels of estrogen are neutralized, and then eliminated from the body. This process can be disrupted by the enzyme beta-glucuronidase, which acts to reactivate the neutralized toxins.

The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification and also encouraging healthy estrogen metabolism. Research has shown that D-glucarate can inhibit breast cancer development in mice by as much as 70% and can lower serum estrogen levels by 23%. Preliminary studies in humans suggest that supplementing with D-glucarate has the same effects on beta-glucuronidase as in animals.

3,3’-Diindolylmethane (DIM)

DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM has been shown to promote the formation of safer estrogen metabolites, shunting estrogen metabolism towards 2-hydroxylated estrogen metabolites instead of 16α-hydroxylated metabolites. DIM has also been shown to prevent breast and cervical cancer cell growth in vitro. It can block the activation of genes that promote cancer cell growth while activating genes that help prevent cancer. As well, in human cases of cervical dysplasia, preliminary open label testing has shown that treatment with DIM can successfully resolve moderate to severe dysplasia.


Sulforaphane is another naturally occurring substance found in broccoli, and is a potent inducer of phase II liver detoxification enzymes. Research has shown that sulforaphane acts directly to inhibit cancer cell growth and initiate apoptosis of cancer cells. When it comes to women’s health, sulforaphane has been shown to inhibit the proliferation of breast cancer cells, and reduce their expression of the estrogen receptor.

Hops Extract – 8-Prenylnaringenin

8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen. In vitro, 8PN has been shown to inhibit breast cancer cell proliferation by interfering with certain pathways mediated by the estrogen receptor. As well, 8PN has been shown to prevent angiogenesis in animal studies. In humans, 8PN has been shown to reduce menopausal symptoms including hot flashes. Lifenol®’s hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.


Choline is a cofactor for phase II detoxification in the liver and for methylation processes that occur throughout the body. Methylation helps deactivate estrogen which can then be excreted. Choline is an excellent addition to Pro Estro Support to support the detoxification of xenobiotics and excess estrogens.

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