Beauty from Within

Final report of the safety assessment of L-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate, and sodium ascorbyl phosphate as used in cosmetics

In 2005 researchers reviewed evidence on the safety and tolerability of ingested and topical use of commercially available ascorbic acid preparations. Given the widespread use in cosmetics, authors assessed preclinical evidence relating to L-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate and sodium ascorbyl phosphate. Helps guide industrial selection of ascorbic acid …

Final report of the safety assessment of L-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate, and sodium ascorbyl phosphate as used in cosmetics Read More »

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study

In a double-blind, placebo-controlled trial from 2018, 53 women aged 40-60 years were randomized to receive 1000 mg of low-molecular weight collagen peptide supplement (a fish-derived collagen hydrolysate) or placebo, daily for 12 weeks. The group given collagen had significantly higher values of skin-hydration after 6 weeks and 12 weeks. Several parameters of skin elasticity …

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study Read More »

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis

In a double-blind, placebo-controlled study from 2014, 114 women aged 45-65 years were randomized to receive 2.5 g of a collagen peptide supplementation or placebo daily for eight weeks. Eye wrinkles were visibly and significantly reduced in the group given collagen (p<0.05) at 4 weeks and 8 weeks. Researchers also detected a significantly higher content …

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β-Carotene and other carotenoids in protection from sunlight

This systematic review published in 2012 provides key insights into the use of carotid micronutrients in the prevention of cellular UV damage. Photoprotection from carotenoids seems to relate to the ability to absorb UV light, diverting light from damaging the cellular structures. Authors suggest that while the evidence for topical use alone is insufficient to …

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Systematic review of carotenoid concentrations in human milk and infant blood

This systematic review published in 2022 defined the carotenoid concentrations in infant blood and human milk highlighting the importance on human health and development and defining nutritional requirements. Carotenoids: b-carotene, lutein, lycopene, and b-cryptoxanthin were the most commonly reported. References: Zaidi, Y., Stroh, R., & Moran, N. E. (2022). Systematic review of carotenoid concentrations in …

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Biotin is required for the zinc homeostasis in the skin

This preclinical study published in 2019 presents insights into the importance of maintaining healthy biotin levels to prevent skin and hair changes often seen with zinc deficiency. References: Ogawa Y, Kinoshita M, Sato T, Shimada S, Kawamura T. Biotin Is Required for the Zinc Homeostasis in the Skin. Nutrients. 2019 Apr 24;11(4):919. doi: 10.3390/nu11040919. PMID: …

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Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review.

In this 2018 systematic review 10 articles (preclinical) were included in the final analysis. These studies demonstrated that vitamin C increases type 1 collagen fibres, scar tissue formation and accelerates bone healing after fracture. References: DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy …

Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Read More »

Supplementation with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: A comparative study with placebo

This randomized, placebo-controlled trial aimed to evaluate the effect astaxanthin, in combination with collagen hydrolysate supplementation on moderately photoaged skin. The results suggest that a combination of astaxanthin and collagen hydrolysate can improve elasticity and barrier integrity in photoaged skin.

Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women

The effect of green tea polyphenols on skin properties has been established in cell culture and animal models. This study looked to evaluate the benefits of green tea polyphenols in modulating the skin properties of healthy female volunteers. The results of this study show that skin structural characteristics, including skin elasticity, roughness, scaling, density and …

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Proline-dependent regulation of collagen metabolism

This review from 2020 focused on available data relating to the role of proline (Pro) in collagen biosynthesis and cellular metabolism. It suggests that Pro availability determines the rate of collagen biosynthesis and demand for Pro in fibroblasts is predominantly met by conversion from Gln. References: This review from 2020 focused on available data relating …

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