Blood Sugar

A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia 

Following 12 weeks of supplementation, this randomized double blind placebo controlled trial had 98 subjects with high cholesterol. There was a significant decrease in total cholesterol, triglycerides, LDL-cholesterol and VLDL cholesterol levels in the amla supplementation group, compared to the placebo group.   References: Upadya, H., Prabhu, S., Prasad, A., Subramanian, D., Gupta, S., & Goel, …

A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia  Read More »

A systematic review on the cardiovascular pharmacology of Melica officinalis Gaertn. 

This systematic review of clinical trials evaluating the effect of Amla on cardiovascular pharmacology was published in 2018. It included 19 cell culture, animal and human clinical studies with the terms “antioxidant, arrhythmia, cardioprotective, cardiotoxicity, heart disease, heart failure, hyperlipidemia, hypertension, myocardial dysfunction and oxidative stress”.   References: Hashem-Dabaghian, F., Ziaee, M., Ghaffari, S., Nabati, F., …

A systematic review on the cardiovascular pharmacology of Melica officinalis Gaertn.  Read More »

Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study 

This randomized, double-blind, placebo-controlled clinical study from 2019  aimed to evaluate the effect of Amla on endothelial dysfunction and corresponding biomarkers of oxidative stress, systemic inflammation and lipid profiles in patients with metabolic syndrome.  References: Usharani, P., Merugu, P. L., & Nutalapati, C. (2019). Evaluation of the effects of a standardized aqueous extract of Phyllanthus …

Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study  Read More »

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women 

This study published in 2021 over 10-weeks was a randomized, placebo-controlled, double-blind trial. Demonstrated an improvement in muscle insulin sensitivity similar to the improvement observed after ~10% weight loss  References: Yoshino, M.,et al (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science (New York, N.Y.), 372(6547), 1224–1229. https://doi.org/10.1126/science.abe9985   

Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy 

This review study published in 2008 compiled data from two published clinical trials involving 1,679 subjects receiving 2g daily assessing for pain scores in patients with diabetic peripheral neuropathy. Both studies found improvements in pain and one also found nerve conduction.    References: Evans, J. D., Jacobs, T. F., & Evans, E. W. (2008). Role of …

Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy  Read More »

The effects of L-carnitine supplementation on glycemic control: A systematic review and meta-analysis of randomized controlled trials 

Authors reviewed 37 RCTs investigating L-carnitine supplementation on glycemic regulation.  This meta-analysis was published in 2019 and reviewed studies published between 1998 and 2018 of which 37 RCT’s met inclusion criteria (total pooled 2467 subjects, 1243 in intervention and 1224 in control groups.) Intervention length varied from 23 days to 12 months and dosages ranged …

The effects of L-carnitine supplementation on glycemic control: A systematic review and meta-analysis of randomized controlled trials  Read More »

L-Carnitine supplementation in recovery after exercise 

This comprehensive review published in 2018, examined the role of L-carnitine supplementation relating to a number of health parameters. Aerobic capacity, fat oxidation, maximum oxygen uptake and physical performance. Authors concluded that L-carnitine supplementation may be an option for management for those facing lean muscle mass and function decline, reduced muscle L-carnitine content and mitochondrial …

L-Carnitine supplementation in recovery after exercise  Read More »

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