Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis
What they did: What they found: What it means:
Cognitive
Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial
This randomized, double blind, placebo-controlled clinical study investigated the effectiveness of Bacopa monniera supplementation on memory performance in healthy older adults. Participants were randomized to receive a placebo or Bacopa, 300 mg per day for 12 weeks and assessed for neuropsychologic and subjective memory assessment at baseline and after 12 weeks of supplementation. Audioverbal and …
An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children
The aim of this open label clinical study was to investigate the effectiveness of a standardized extract of Bacopa monnieri in improving the severity of ADHD symptoms. Children aged 6-12 years old, with an age of onset prior to 7 years of age were recruited for the study and received 225 mg bacopa extract daily …
Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase II clinical trial
This double-blind early phase II randomized placebo-controlled trial published in 2020, was conducted of benfotiamine with the objective of collecting preliminary data on feasibility, safety and efficacy in mild cognitive impairments, mild dementia experienced by Alzheimer’s patients (amyloid positive). Results suggest that benfotiamine offers a low cost, high safety intervention that can improve outcomes for …
Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial
This randomized, double blind, placebo-controlled trial planned to evaluate the effects of bacopa supplementation on cognitive function in healthy, elderly, study participants. Participants were randomized to receive a placebo or bacopa (300 mg/day) for 12 weeks, with a placebo run-in of 6 weeks. Each participant was assessed by the following measures: Rey Auditory Verbal Learning …
Choline supplements: An update
From 2023, this review of supplemental forms of choline currently available includes choline alfoscerate also known as alpha-glycerophosphocholine (α-GPC or GPC), choline bitartrate, lecithin and citicoline. One of the most used is choline bitartrate, which has shown favorable effects both in preclinical and clinical studies, especially in terms of improved cognitive function. References: Kansakar U, …
Neuroprotective effects of thiamine and precursors with higher bioavailability: Focus on benfotiamine and dibenzoylthiamine
Published in 2022, this recent review offers insights into clinical and preclinical evidence of thiamin precursors and their neuroprotective potential. Authors conclude that human clinical research appears promising and requires more support in neurodegenerative diseases and stress-induced anxiety, aggression and depression. With no toxic side-effects reported it is suggested to be a potentially safe and …
Cardioprotection and lifespan extension by the natural polyamine spermidine
This 2016 animal study also included a prospective population based cohort where human consumption of spermidine was assessed in relation to prevalence of cardiovascular events. We also provide evidence that dietary spermidine intake in humans inversely correlates with cardiovascular disease. Authors found intake was inversely associated with the risk of both fatal heart failure (a …
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The positive effect of spermidine in older adults suffering from dementia: First results of a 3-month trial
This randomized, two-group, double-blind, multicentric and longitudinal study of men and women in facilities for cognitive decline. 92 older individuals (60–96 years of age) participated in the study. This randomized, two-group, double-blind, multicentric and longitudinal study of men and women in facilities for cognitive decline. 92 older individuals (60–96 years of age) participated in the …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults with Subjective Cognitive Decline: A Randomized Clinical Trial
This study known as the SmartAge study was a monocenter, randomized, double-masked, placebo-controlled phase 2b trial. The intervention included 89 participants (aged 60-90 years old) and 12-month dietary spermidine supplementation. Researchers suggest that supplementation with dietary spermidine might not act as a memory booster, but rather prevent age-related memory impairment and development of AD. References: …