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Detoxification

Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: A review 

In this review published in 2020 researchers explored the impact of milk thistle extracts on mitigating impacts of exposure to biological toxins (e.g. mycotoxins, snake venoms, bacterial toxins) or chemical toxic agents (e.g. metals, pesticides, cardiotoxic, neurotoxic, hepatotoxic and nephrotoxic agents). Authors examined preclinical data that defined constituents that had radical scavenging, anti-oxidative, anti-apoptotic properties.  …

Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: A review  Read More »

Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review 

This review published in 2018 summarized different animal and human studies regarding the effect of S. marianum in metabolic syndrome to identify the underlying mechanisms of action. Silymarin is the main component of S. marianum and derived from fruits and seeds of S. marianum (milk thistle). S. marianum has been found to exhibit antioxidant, lipid-lowering, …

Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review  Read More »

The multifaceted therapeutic role of N-Acetylcysteine (NAC) in disorders characterized by oxidative stress 

From 2021 this narrative review provides an overview of the most relevant and recent evidence on the clinical application of NAC, with a focus on respiratory diseases, acetaminophen poisoning, disorders of the central nervous system (chronic neuropathic pain, depression, schizophrenia, bipolar disorder, and addiction), cardiovascular disease, contrast-induced nephropathy, and ophthalmology (retinitis pigmentosa).  References: Raghu G, …

The multifaceted therapeutic role of N-Acetylcysteine (NAC) in disorders characterized by oxidative stress  Read More »

The effects of N-Acetylcysteine on serum level of inflammatory biomarkers in adults. Findings from a systematic review and meta-analysis of randomized clinical trials. 

In this systematic review and meta-analysis from 2020, 24 randomized clinical trials (n=1057) aimed to assess the effects of NAC supplementation on inflammatory markers. The anti-inflammatory properties of NAC have been of considerable controversies in the past. NAC is a powerful antioxidant, which can help neutralize free radicals. It also aids in the synthesis of …

The effects of N-Acetylcysteine on serum level of inflammatory biomarkers in adults. Findings from a systematic review and meta-analysis of randomized clinical trials.  Read More »

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