This monograph from 2007 provides a review of available evidence for the therapeutic uses of calcium D glucarate. Through suppression of beta glucuronidase activity, hormone and lipid excretion can occur as normal making this particularly useful in excess conditions. References: Calcium-D-glucarate. Altern Med Rev. 2002;7(4):336‐339. https://pubmed.ncbi.nlm.nih.gov/12197785/
This review from 2023 covers the mechanistic evidence for liver benefits of calcium d glucarate specifically glucaric acid. Authors explain four specific molecular pathways: improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting β-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes. References: Ayyadurai VAS, Deonikar P, Fields …
This is a review from 2020 that discusses the findings thus far in terms of the potential benefits of inositol and IP6 in the treatment of diabetes. IP6 is also known as phytic acid and is found naturally in grains and oil seeds. Some of the most abundant sources are wheat bran and flaxseeds. At …
Published in 2016 this double blinded randomized controlled trial (RCT), conducted on 85 female PCOS patients (20–35 years old) to assess the effects of chromium supplementation on fasting glucose insulin ration, BMI, fasting blood sugar. The treatment group did demonstrate a significant reduction in fasting serum insulin levels. References: Ashoush S, Abou-Gamrah A, Bayoumy H, …
Published in 2021 this randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients. Researchers concluded that supplementation over 12 weeks has a positive impact on patients with NAFLD’s leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. References: Kooshki F, Moradi F, Karimi A, Niazkar HR, Khoshbaten M, Maleki V, …
This review looked at literature relating to benefits of chromium supplementation on metabolic parameters of subjects with type 2 DM. Twenty-eight studies reported fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C) and homeostatic model assessment for insulin resistance (HOMA-IR) as an outcome measure. Results revealed significant reduction in FPG, insulin level, HbA1C and HOMA-IR after …
This meta-analysis from 2011 assessed the effects of cinnamon extracts on blood glucose in patients with type 2 diabetes and/or prediabetes. Eight clinical studies designed as randomized, placebo-controlled trials were included. Authors concluded that results of the eight studies demonstrated statistically significant benefits for type 2 diabetics or prediabetics for lowering their blood glucose. References: …
Cinnamon intake lowers fasting blood glucose: meta-analysis. Read More »
Published in 2020, this review highlights the evidence relating to a mechanism of action as well as eight clinical studies that outline the use of cinnamon for blood sugar regulation. With authors concluding that as a “complementary therapy, it should not be viewed as an alternative to established glucose lowering drugs. While the exact dose …
Is cinnamon efficacious for glycaemic control in type-2 diabetes mellitus? Read More »
From 1985 this preclinical study set the stage for much of our mechanistic understanding of Coleus. Authors identified forskolin, the main active compound, may mainly act on the catalytic component of adenylate cyclase. Suggesting that it stimulates adenylate cyclase in human thyroid membranes by a novel mechanism that differs from TSH- or Gpp(NH)p-stimulation, and that …
Forskolin stimulation of adenylate cyclase in human thyroid membranes Read More »
In this 2016 randomized, controlled prospective study of 192 adults with autoimmune thyroiditis, patients were given either 83 mcg SeMet daily or no treatment for four months. At the end of the study, 31.3% of patients in the SeMet group had restored euthyroidism (TSH <4.5mUI/L) compared to 3.1% of patients in the control group. References: …
