This review from 2006 includes insights on all B vitamins and their role in energy production in the mitochondria. Authors outline preclinical evidence of the mechanism of action of biotin as a critical coenzyme. It is imperative for gluconeogenesis and fatty acid oxidation due to its role as a decarboxylase co-enzyme. References: Depeint F, Bruce …
From 2020 this review offers a look into the natural sources of 5-HTP, the chemical analysis and synthesis, biosynthesis and microbial production. Evidence examining the physiological effects of 5-HTP in the treatment of depression, anxiety, panic, sleep disorders, obesity, myoclonus and serotonin syndrome are also discussed. 5-HTP toxicity and the occurrence of toxic impurities present …
An open label clinical study published in 2017 assessed the benefit of a combination of creatine and 100 mg of 5-HTP twice daily, in combination with already approved SSRIs or SNRIs (selective norepinephrine reuptake inhibitors). Supplementation was given for 8 weeks, with 4 weeks of post treatment follow up, with the primary endpoint being a …
A systematic review from 2021 and a meta-analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo respectively, without serious side effects. …
From 2022 this comprehensive review analyzes the properties of this plant updating currently available literature, with a special emphasis on human studies. Providing compositional insights related to specific actions as an antioxidant, anti-inflammatory, antispasmodic, antimicrobial, neuroprotective, nephroprotective, antinociceptive effects. Making it helpful in the management of and against different human diseases, such as anxiety, sleeping …
A 2010 systematic review has been performed on the effects of maca on sexual function in humans. Four randomized clinical trials (RCT) met all the inclusion criteria. According to the review, two RCTs suggested a significant positive effect of maca on sexual dysfunction or sexual desire in healthy menopausal women or healthy adult men, while …
Maca (L. meyenii) for improving sexual function: A systematic review Read More »
This review from 2020 examines evidence of the Peruvian maca composition and the recent findings regarding the medicinal effects of this root in sexual dysfunction regulation, neuroprotective effects, action in memory enhancement, antidepressant, antioxidant, anti-cancer, anti-inflammatory activities and skin protection. References: da Silva Leitão Peres N , Cabrera Parra Bortoluzzi L , Medeiros Marques LL …
Medicinal effects of Peruvian maca (Lepidium meyenii): A review Read More »
A 2012, double-blind randomized clinical trial aimed to determine the efficacy of Mg supplementation to improve insomnia in the elderly. In this study, 46 elderly subjects were randomly allocated into the Mg or the placebo group and received 500 mg magnesium or placebo daily for eight weeks. Supplementation of Mg appears to improve subjective measures …
In a recent 2018 review of the literature, researchers have investigated magnesium research across neurological conditions. Current literature has been reviewed for migraine, chronic pain, epilepsy, Alzheimer’s, Parkinson’s and stroke, as well as the commonly comorbid conditions of anxiety and depression. References: Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. …
This 2017 review was the first systemic review of human clinical trials relating to clinical effects of ingested holy basil (common name tulsi). The review found 24 articles that met their inclusion criteria with the most outcome measures relating to blood glucose levels, lipid profile, blood pressure, immune response, neurocognitive changes, fatigue and mood. Regarding …
