Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis
What they did: What they found: What it means:
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The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: A randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
Published in 2023 this randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial assessed for safety and tolerability of NMN on metabolic parameters that relate to aging. The results confirmed that orally administered NMN is absorbed and quickly converted into NAD in human blood. NAD blood levels were increased in a dose dependent manner. References: Yi …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults with Subjective Cognitive Decline: A Randomized Clinical Trial
This study known as the SmartAge study was a monocenter, randomized, double-masked, placebo-controlled phase 2b trial. The intervention included 89 participants (aged 60-90 years old) and 12-month dietary spermidine supplementation. Researchers suggest that supplementation with dietary spermidine might not act as a memory booster, but rather prevent age-related memory impairment and development of AD. References: …