Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis
What they did: What they found: What it means:
Health Conditions
Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial
This randomized, double blind, placebo-controlled clinical study investigated the effectiveness of Bacopa monniera supplementation on memory performance in healthy older adults. Participants were randomized to receive a placebo or Bacopa, 300 mg per day for 12 weeks and assessed for neuropsychologic and subjective memory assessment at baseline and after 12 weeks of supplementation. Audioverbal and …
An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children
The aim of this open label clinical study was to investigate the effectiveness of a standardized extract of Bacopa monnieri in improving the severity of ADHD symptoms. Children aged 6-12 years old, with an age of onset prior to 7 years of age were recruited for the study and received 225 mg bacopa extract daily …
Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials
This meta-analysis published in 2021 relating to the effect of BCAAs supplementation on plasma muscle damage markers and soreness after resistance exercise in only trained males. Nine studies met the inclusion criteria with a total of 278 participants ranging from 21.5 to 24.7 years old. Study length ranged from 1-28 days and supplementation schedules included …
Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances and energy metabolism substances
To determine the effects of BCAA supplementation on fatigue, muscle damage and energy metabolism after endurance exercise, this randomized, double-blind, placebo-controlled clinical trial from 2013 was carried out. These results suggest that BCAA may reduce muscle damage associated with endurance exercise.
Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase II clinical trial
This double-blind early phase II randomized placebo-controlled trial published in 2020, was conducted of benfotiamine with the objective of collecting preliminary data on feasibility, safety and efficacy in mild cognitive impairments, mild dementia experienced by Alzheimer’s patients (amyloid positive). Results suggest that benfotiamine offers a low cost, high safety intervention that can improve outcomes for …
Benfotiamine in the treatment of diabetic polyneuropathy – A three-week randomized, controlled pilot study (BEDIP study)
Published in 2008 this six-week, double blind, placebo-controlled, phase-III-study recruited 165 patients with symmetrical, distal diabetic polyneuropathy. Authors found a dose dependent improvement in the neuropathic symptom scores with the benfotiamine treatment group. References: Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2008). Benfotiamine in diabetic polyneuropathy (BENDIP): results of a …
Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes
This human clinical pilot study from 2008 set the basis of future research in whether benfotiamine in combination with α-lipoic acid would normalize markers of reactive oxygen species-induced pathways of complications in humans. Authors found the intervention with oral benfotiamine plus α-lipoic acid normalises several complications-causing pathways in patients with type 1 diabetes. References: Du, …
Review on pharmacognostic, phytochemical and pharmacological characteristics of medicinal plants which can be used to design a novel ayurvedic formulation to treat hypertension in multidimensional approaches
This review from 2023 evaluates extraction methods of the active phytoconstituents and pharmacognostic, physiochemical, phytochemical and quantitative analysis parameters, and the different pharmacological modes of action for ayurvedic plants traditionally used for the management of blood pressure. Concluding that Boerhavia diffusa consists of active ingredients: Liriodendron & Syringaresinol mono β-D-Glucosidase which can exhibit Ca2+ channel …
Pivotal role of boron supplementation on bone health: A narrative review
This review from 2020 included 11 eligible studies evaluating the effectiveness of boron supplementation (alone or with other micronutrients) on growth and maintenance of bone in humans through control of calcium, vitamin D and sex steroid hormone metabolism. Authors concluded supplementation of 3 mg / day is considered useful to support bone health (in order to …
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