Healthy Aging

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial  

This randomized, double blind, placebo-controlled clinical study investigated the effectiveness of Bacopa monniera supplementation on memory performance in healthy older adults. Participants were randomized to receive a placebo or Bacopa, 300 mg per day for 12 weeks and assessed for neuropsychologic and subjective memory assessment at baseline and after 12 weeks of supplementation. Audioverbal and …

Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial   Read More »

An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children  

The aim of this open label clinical study was to investigate the effectiveness of a standardized extract of Bacopa monnieri in improving the severity of ADHD symptoms. Children aged 6-12 years old, with an age of onset prior to 7 years of age were recruited for the study and received 225 mg bacopa extract daily …

An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children   Read More »

Benfotiamine in the treatment of diabetic polyneuropathy – A three-week randomized, controlled pilot study (BEDIP study) 

Published in 2008 this six-week, double blind, placebo-controlled, phase-III-study recruited 165 patients with symmetrical, distal diabetic polyneuropathy. Authors found a dose dependent improvement in the neuropathic symptom scores with the benfotiamine treatment group.     References: Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2008). Benfotiamine in diabetic polyneuropathy (BENDIP): results of a …

Benfotiamine in the treatment of diabetic polyneuropathy – A three-week randomized, controlled pilot study (BEDIP study)  Read More »

Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes 

This human clinical pilot study from 2008 set the basis of future research in whether benfotiamine in combination with α-lipoic acid would normalize markers of reactive oxygen species-induced pathways of complications in humans. Authors found the intervention with oral benfotiamine plus α-lipoic acid normalises several complications-causing pathways in patients with type 1 diabetes.  References: Du, …

Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes  Read More »

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial 

This randomized, double blind, placebo-controlled trial planned to evaluate the effects of bacopa supplementation on cognitive function in healthy, elderly, study participants. Participants were randomized to receive a placebo or bacopa (300 mg/day) for 12 weeks, with a placebo run-in of 6 weeks. Each participant was assessed by the following measures: Rey Auditory Verbal Learning …

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial  Read More »

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study 

In a double-blind, placebo-controlled trial from 2018, 53 women aged 40-60 years were randomized to receive 1000 mg of low-molecular weight collagen peptide supplement (a fish-derived collagen hydrolysate) or placebo, daily for 12 weeks. The group given collagen had significantly higher values of skin-hydration after 6 weeks and 12 weeks. Several parameters of skin elasticity …

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study  Read More »

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis 

In a double-blind, placebo-controlled study from 2014, 114 women aged 45-65 years were randomized to receive 2.5 g of a collagen peptide supplementation or placebo daily for eight weeks. Eye wrinkles were visibly and significantly reduced in the group given collagen (p<0.05) at 4 weeks and 8 weeks. Researchers also detected a significantly higher content …

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis  Read More »

Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. 

In the adult male study, healthy participants were given 300 mg MBP per day for 16 days and assessed for markers of bone loss. The results show a significant decrease in bone metabolism and bone loss. A decrease in urinary cross-linked N-teleopeptides of type-I collagen (NTx) excretion was also observed, suggesting that MBP promoted bone …

Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men.  Read More »

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: A randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial 

Published in 2023 this randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial assessed for safety and tolerability of NMN on metabolic parameters that relate to aging. The results confirmed that orally administered NMN is absorbed  and quickly converted into NAD in human blood.  NAD blood levels were increased in a dose dependent manner.   References: Yi …

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: A randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial  Read More »

β-Carotene and other carotenoids in protection from sunlight 

This systematic review published in 2012 provides key insights into the use of carotid micronutrients in the prevention of cellular UV damage. Photoprotection from carotenoids seems to relate to the ability to absorb UV light, diverting light from damaging the cellular structures. Authors suggest that while the evidence for topical use alone is insufficient to …

β-Carotene and other carotenoids in protection from sunlight  Read More »

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