Metabolic

Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase II clinical trial

This double-blind early phase II randomized placebo-controlled trial published in 2020, was conducted of benfotiamine with the objective of collecting preliminary data on feasibility, safety and efficacy in mild cognitive impairments, mild dementia experienced by Alzheimer’s patients (amyloid positive). Results suggest that benfotiamine offers a low cost, high safety intervention that can improve outcomes for …

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Benfotiamine in the treatment of diabetic polyneuropathy – A three-week randomized, controlled pilot study (BEDIP study)

Published in 2008 this six-week, double blind, placebo-controlled, phase-III-study recruited 165 patients with symmetrical, distal diabetic polyneuropathy. Authors found a dose dependent improvement in the neuropathic symptom scores with the benfotiamine treatment group. References: Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2008). Benfotiamine in diabetic polyneuropathy (BENDIP): results of a …

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Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes

This human clinical pilot study from 2008 set the basis of future research in whether benfotiamine in combination with α-lipoic acid would normalize markers of reactive oxygen species-induced pathways of complications in humans. Authors found the intervention with oral benfotiamine plus α-lipoic acid normalises several complications-causing pathways in patients with type 1 diabetes. References: Du, …

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Calcium D Glucarate Monograph for Detoxification

This monograph from 2007 provides a review of available evidence for the therapeutic uses of calcium D glucarate. Through suppression of beta glucuronidase activity, hormone and lipid excretion can occur as normal making this particularly useful in excess conditions. References: Calcium-D-glucarate. Altern Med Rev. 2002;7(4):336‐339. https://pubmed.ncbi.nlm.nih.gov/12197785/

Mechanistic understanding of D-glucaric acid to support liver detoxification essential to muscle health using a computational systems biology approach

This review from 2023 covers the mechanistic evidence for liver benefits of calcium d glucarate specifically glucaric acid. Authors explain four specific molecular pathways: improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting β-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes. References: Ayyadurai VAS, Deonikar P, Fields …

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New frontiers for the use of IP6 and inositol combination in treating diabetes mellitus: A review 

This is a review from 2020 that discusses the findings thus far in terms of the potential benefits of inositol and IP6 in the treatment of diabetes. IP6 is also known as phytic acid and is found naturally in grains and oil seeds. Some of the most abundant sources are wheat bran and flaxseeds. At …

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Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

From 2012, this review looks at the effect of choline on liver function and fatty liver disease. Humans eating low-choline diets develop fatty liver and liver damage. Choline influences liver function, and the dietary requirement for this nutrient varies depending on an individual’s genotype and estrogen status. References: Corbin KD, Zeisel SH. Choline metabolism provides …

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Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.

Published in 2016 this double blinded randomized controlled trial (RCT), conducted on 85 female PCOS patients (20–35 years old) to assess the effects of chromium supplementation on fasting glucose insulin ration, BMI, fasting blood sugar. The treatment group did demonstrate a significant reduction in fasting serum insulin levels. References: Ashoush S, Abou-Gamrah A, Bayoumy H, …

Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial. Read More »

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

Published in 2021 this randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients. Researchers concluded that supplementation over 12 weeks has a positive impact on patients with NAFLD’s leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. References: Kooshki F, Moradi F, Karimi A, Niazkar HR, Khoshbaten M, Maleki V, …

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial Read More »

Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

This review looked at literature relating to benefits of chromium supplementation on metabolic parameters of subjects with type 2 DM. Twenty-eight studies reported fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C) and homeostatic model assessment for insulin resistance (HOMA-IR) as an outcome measure. Results revealed significant reduction in FPG, insulin level, HbA1C and HOMA-IR after …

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