Mood

Body weight management in adults under chronic stress through treatment with ashwagandha root extract: A double-blind, randomized, placebo-controlled trial.

This study published in 2017 examined the role of ashwagandha (n=25, placebo n=25) in reducing perceived stress and subsequent weight gain in healthy subjects over eight weeks of supplementation. The results indicated statistically significant improvements in both the primary and secondary measures as compared to placebo. Indicating this may be a good option for management …

Body weight management in adults under chronic stress through treatment with ashwagandha root extract: A double-blind, randomized, placebo-controlled trial. Read More »

Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical Study.

This 2019, eight week randomised double-blind placebo controlled study of 58 participants examined the dose dependent effects of aqueous ashwagandha root extract on otherwise healthy participants facing stress and anxiety. The 300 mg group had the most pronounced decrease in Perceived Stress Scale (PSS) scores from baseline. References: Salve J, Pate S, Debnath K, Langade …

Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical Study. Read More »

Carnitine and Depression

This comprehensive review published in 2022 outlined critical research related to acylcarnitine levels in depression and other mood disorders such as bipolar. Authors offer insights into the effect of acetyl-L- carnitine on neuroplasticity, oxidative stress and neurotransmitter regulation. And conclude levels may help in diagnosis and supplementation for treatment of psychiatric diseases. References: Liu, T., …

Carnitine and Depression Read More »

Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): Results of a placebo-controlled, cross-over clinical trial

Clinical trial in 2019, published in Obstetrics & Gynecology Science. Oxaloacetate acid could be helpful in decreasing depression, perceived stress, anxiety, aggression and suicidal ideation caused by PMS. References: Tully, L., Humiston, J., & Cash, A. (2020). Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial. Obstetrics & Gynecology …

Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): Results of a placebo-controlled, cross-over clinical trial Read More »

Grape seed extract positively modulates blood pressure and perceived stress: A randomized, double-blind, placebo-controlled study in healthy volunteers

A randomized, double-blind, placebo-controlled clinical study from 2021 was conducted in subjects with mild hypertension. It was performed to investigate GSEe benefits on blood pressure regulation. GSEe resulted in a benefit of modulating endothelial functionality and blood pressure. It was noteworthy that GSEe relieved the perceived stress, promising new future perspectives on mood comfort. References: …

Grape seed extract positively modulates blood pressure and perceived stress: A randomized, double-blind, placebo-controlled study in healthy volunteers Read More »

A comprehensive review for phytochemical, pharmacological, and biosynthesis studies on Glycyrrhiza spp

This comprehensive review from 2020 examines the three species of licorice and the nearly 400 chemical compounds active within. Systematically reviewing evidence for the pharmacological activities, including metabolism via CYP450 system in vivo, and introducs the complete biosynthesis pathway of glycyrrhizin in licorice. References: Wang, C., Chen, L., Xu, C., Shi, J., Chen, S., Tan, …

A comprehensive review for phytochemical, pharmacological, and biosynthesis studies on Glycyrrhiza spp Read More »

Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae)

From 2020, this review provides additional insights into traditional and current therapeutic uses of licorice extracts in humans along with a complete breakdown of active constituents. Citing traditional use for respiratory disorders, hyperdipsia, epilepsy, fever, sexual debility, paralysis, stomach ulcers, rheumatism, skin diseases, hemorrhagic diseases and jaundice. References: El-Saber Batiha, G., Magdy Beshbishy, A., El-Mleeh, …

Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae) Read More »

5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology

From 2020 this review offers a look into the natural sources of 5-HTP, the chemical analysis and synthesis, biosynthesis and microbial production. Evidence examining the physiological effects of 5-HTP in the treatment of depression, anxiety, panic, sleep disorders, obesity, myoclonus and serotonin syndrome are also discussed. 5-HTP toxicity and the occurrence of toxic impurities present …

5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology Read More »

An open-label pilot study of combined augmentation with creatine monohydrate and 5-Hydroxytryptophan for selective serotonin reuptake inhibitor – or serotonin – norepinephrine reuptake inhibitor -resistant depression in adult women

An open label clinical study published in 2017 assessed the benefit of a combination of creatine and 100 mg of 5-HTP twice daily, in combination with already approved SSRIs or SNRIs (selective norepinephrine reuptake inhibitors). Supplementation was given for 8 weeks, with 4 weeks of post treatment follow up, with the primary endpoint being a …

An open-label pilot study of combined augmentation with creatine monohydrate and 5-Hydroxytryptophan for selective serotonin reuptake inhibitor – or serotonin – norepinephrine reuptake inhibitor -resistant depression in adult women Read More »

L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study

In a randomized, double blind, placebo controlled trial, 44 patients with moderate to severe obsessive compulsive disorder (OCD) were given either L-carnosine or placebo daily in addition to fluvoxamine. After 10 weeks of treatment there were significant reductions in obsessive compulsive symptoms in the group given L-carnosine compared to placebo. References: Arabzadeh S, Shahhossenie M, …

L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study Read More »

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