Pain and Inflammation

Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines

In this small proof of concept clinical study from 2011, eight healthy male volunteers were assessed for the impact of short- and long-term boron supplementation on various inflammatory cytokines and steroid hormones. Boron in plasma increased significantly following hours and weekly consumption. Six hours after supplementation showed a significant decrease on sex hormone binding globulin …

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Effects of gum resin of Boswellia serrata in patients with chronic colitis.

In this 2001 clinical trial, Gupta and his colleagues studied the effects of gum resin of Boswellia serrata in patients with chronic colitis. Thirty patients, 17 males and 13 females in the age range of 18 to 48 years with chronic colitis were included in this study. Twenty patients were given a preparation of the …

Effects of gum resin of Boswellia serrata in patients with chronic colitis. Read More »

A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.

In this 2008, double-blind, randomized, placebo-controlled study on 75 osteoarthritis (OA) patients, the researchers evaluated the efficacy and safety of 5-Loxin in the treatment of OA of the knee over a 90-day period. 5-Loxin is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase …

A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Read More »

Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage

This 2015 preclinical paper examines the pharmacological mechanisms mediated by BSE, in protecting intestinal epithelial barrier from inflammatory damage and supports its use as a safe adjuvant in patients affected by IBD. Fortification of the intestinal barrier function is still a challenge in acute or chronic colonic cell lines and supplementation with Boswellia demonstrated key …

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Bovine colostrum applications in sick and healthy people: A systematic review

This comprehensive review published in 2021 evaluated evidence relating to the clinical use of exogenous supplemental bovine colostrum in human health. 24 full text studies were selected and reviewed regarding intestinal and respiratory recovery. The mechanism of action seemed to suggest bovine colostrum modulates the immune response and may increase sIgA. References: Guberti, M., Botti, …

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Bovine colostrum: Its constituents and uses

This comprehensive review published in 2021 in Nutrients, reviews the main constituents, quality control and an overview of the use of bovine colostrum in health and disease. Bovine colostrum active constituents include immunoglobulins, cytokines, oligosaccharides and immune factors. It also contains growth factors and hormones which account for many of the health benefits. Multiple studies …

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The use of bovine colostrum in medical practice and human health: Current evidence and areas requiring further examination

The prestigious scientific journal Nutrients published this special edition in 2022 for a comprehensive review of the health potential of bovine colostrum supplementation. Including five review articles, use in gastrointestinal health and disease, sports nutrition, pediatrics, and immune support. It also includes a systematic review of its clinical use and an original research article examining …

The use of bovine colostrum in medical practice and human health: Current evidence and areas requiring further examination Read More »

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

A study published in the American Journal of Sports Medicine in 2014 consisting of a systematic review of 13 randomized controlled trials evaluated the effectiveness of 12 different agents in preserving articular cartilage of the knee and delaying the progression of osteoarthritis. Treatment with chondroitin sulfate showed a significant reduction in cartilage loss in three …

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. Read More »

Update on the role of pharmaceutical-grade chondroitin sulfate (CS) in the symptomatic management of knee osteoarthritis.

In this literature review from 2019, the authors summarized the most recent findings on the efficacy and safety of CS in OA. Based on the results of studies presenting a low risk of bias, the most recent meta-analysis shows that only the pharmaceutical-grade CS may be considered as an appropriate background treatment for the management …

Update on the role of pharmaceutical-grade chondroitin sulfate (CS) in the symptomatic management of knee osteoarthritis. Read More »

Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials

A meta-analysis of randomized controlled trials published in the Journal of Orthopaedics Surgery and Research in 2018 assessed the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. Twenty-six articles describing 30 trials met the …

Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials Read More »

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