RCT

Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase II clinical trial

This double-blind early phase II randomized placebo-controlled trial published in 2020, was conducted of benfotiamine with the objective of collecting preliminary data on feasibility, safety and efficacy in mild cognitive impairments, mild dementia experienced by Alzheimer’s patients (amyloid positive). Results suggest that benfotiamine offers a low cost, high safety intervention that can improve outcomes for …

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Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes

This human clinical pilot study from 2008 set the basis of future research in whether benfotiamine in combination with α-lipoic acid would normalize markers of reactive oxygen species-induced pathways of complications in humans. Authors found the intervention with oral benfotiamine plus α-lipoic acid normalises several complications-causing pathways in patients with type 1 diabetes. References: Du, …

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Effects of gum resin of Boswellia serrata in patients with chronic colitis.

In this 2001 clinical trial, Gupta and his colleagues studied the effects of gum resin of Boswellia serrata in patients with chronic colitis. Thirty patients, 17 males and 13 females in the age range of 18 to 48 years with chronic colitis were included in this study. Twenty patients were given a preparation of the …

Effects of gum resin of Boswellia serrata in patients with chronic colitis. Read More »

A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.

In this 2008, double-blind, randomized, placebo-controlled study on 75 osteoarthritis (OA) patients, the researchers evaluated the efficacy and safety of 5-Loxin in the treatment of OA of the knee over a 90-day period. 5-Loxin is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase …

A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Read More »

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial

This randomized double-blind placebo-controlled trial published in 2022 assessed the efficacy of two types of calcium forms: carbonate and citrate in the ability to increase calcium levels in individuals with parathyroid deficiencies. Both forms were effective in increasing serum calcium levels. Calcium citrate seems to have increased urine oxalate excretion which may reduce risks for …

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial Read More »

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial

This randomized double-blind placebo-controlled trial published in 2022 assessed the efficacy of two types of calcium forms: carbonate and citrate in the ability to increase calcium levels in individuals with parathyroid deficiencies. Both forms were effective in increasing serum calcium levels. References: Naciu AM, Tabacco G, Bilezikian JP, Santonati A, Bosco D, Incognito GG, …

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial Read More »

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

Published in 2021 this randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients. Researchers concluded that supplementation over 12 weeks has a positive impact on patients with NAFLD’s leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. References: Kooshki F, Moradi F, Karimi A, Niazkar HR, Khoshbaten M, Maleki V, …

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial Read More »

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: A double blind, placebo, controlled randomized clinical trial

This randomized, double-blind, placebo-controlled clinical study from 2015 showed that MS patients receiving 500 mg/day of CoQ10 for 12 weeks presented with a significant decrease of inflammatory cytokine. CoQ10 also alleviates markers of CNS inflammation. References: Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Khodadadi B, Jazayeri S, Gohari MR, Aryaeian N. Coenzyme Q10 supplementation …

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: A double blind, placebo, controlled randomized clinical trial Read More »

Coleus forskohlii extract supplementation in conjunction with hypocaloric diet reduces risk of factors of metabolic syndrome in overweight and obese subjects: a randomized controlled trial

In a randomized, double-blind controlled trial from 2015, 30 overweight or obese participants were given either 250 mg C. forskohlii extract or placebo twice daily for 12 weeks. Participants in both groups were to follow a hypocaloric diet throughout the study. At the end of the study both groups had significant reductions in hip and …

Coleus forskohlii extract supplementation in conjunction with hypocaloric diet reduces risk of factors of metabolic syndrome in overweight and obese subjects: a randomized controlled trial Read More »

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study

In a double-blind, placebo-controlled trial from 2018, 53 women aged 40-60 years were randomized to receive 1000 mg of low-molecular weight collagen peptide supplement (a fish-derived collagen hydrolysate) or placebo, daily for 12 weeks. The group given collagen had significantly higher values of skin-hydration after 6 weeks and 12 weeks. Several parameters of skin elasticity …

Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity and wrinkling in human skin: A randomized, double-blind, placebo-controlled study Read More »

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