Skeletal

Pivotal role of boron supplementation on bone health: A narrative review

This review from 2020 included 11 eligible studies evaluating the effectiveness of boron supplementation (alone or with other micronutrients) on growth and maintenance of bone in humans through control of calcium, vitamin D and sex steroid hormone metabolism. Authors concluded supplementation of 3 mg / day is considered useful to support bone health (in order to …

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Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines

In this small proof of concept clinical study from 2011, eight healthy male volunteers were assessed for the impact of short- and long-term boron supplementation on various inflammatory cytokines and steroid hormones. Boron in plasma increased significantly following hours and weekly consumption. Six hours after supplementation showed a significant decrease on sex hormone binding globulin …

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A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.

In this 2008, double-blind, randomized, placebo-controlled study on 75 osteoarthritis (OA) patients, the researchers evaluated the efficacy and safety of 5-Loxin in the treatment of OA of the knee over a 90-day period. 5-Loxin is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase …

A double blind, randomized, placebo-controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Read More »

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial

This randomized double-blind placebo-controlled trial published in 2022 assessed the efficacy of two types of calcium forms: carbonate and citrate in the ability to increase calcium levels in individuals with parathyroid deficiencies. Both forms were effective in increasing serum calcium levels. Calcium citrate seems to have increased urine oxalate excretion which may reduce risks for …

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial Read More »

Calcium supplementation in clinical practice: A review of forms, doses and indications

This review from 2007 is the only comprehensive assessment of the various types of calcium salt forms. Suggesting that calcium carbonate offers an effective and cost-efficient form that should be taken with a meal to ensure optimal absorption. References: Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin …

Calcium supplementation in clinical practice: A review of forms, doses and indications Read More »

Calcium supplementation in clinical practice: A review of forms, doses and indications

This review from 2007 is the only comprehensive assessment of the various types of calcium salt forms. Suggesting that calcium citrate can be taken without food and is the supplement of choice for individuals with achlorhydria or who are taking histamine-2 blockers or protein-pump inhibitors. References: Straub DA. Calcium supplementation in clinical practice: a review of …

Calcium supplementation in clinical practice: A review of forms, doses and indications Read More »

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial

This randomized double-blind placebo-controlled trial published in 2022 assessed the efficacy of two types of calcium forms: carbonate and citrate in the ability to increase calcium levels in individuals with parathyroid deficiencies. Both forms were effective in increasing serum calcium levels. References: Naciu AM, Tabacco G, Bilezikian JP, Santonati A, Bosco D, Incognito GG, …

Calcium citrate versus calcium carbonate in the management of chronic hypoparathyroidism: A randomized, double-blind, crossover clinical trial Read More »

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

A study published in the American Journal of Sports Medicine in 2014 consisting of a systematic review of 13 randomized controlled trials evaluated the effectiveness of 12 different agents in preserving articular cartilage of the knee and delaying the progression of osteoarthritis. Treatment with chondroitin sulfate showed a significant reduction in cartilage loss in three …

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. Read More »

Update on the role of pharmaceutical-grade chondroitin sulfate (CS) in the symptomatic management of knee osteoarthritis.

In this literature review from 2019, the authors summarized the most recent findings on the efficacy and safety of CS in OA. Based on the results of studies presenting a low risk of bias, the most recent meta-analysis shows that only the pharmaceutical-grade CS may be considered as an appropriate background treatment for the management …

Update on the role of pharmaceutical-grade chondroitin sulfate (CS) in the symptomatic management of knee osteoarthritis. Read More »

Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials

A meta-analysis of randomized controlled trials published in the Journal of Orthopaedics Surgery and Research in 2018 assessed the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. Twenty-six articles describing 30 trials met the …

Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials Read More »

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