Sleep

The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis

A systematic review from 2021 and a meta-analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo respectively, without serious side effects. …

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An updated review on the properties of Melissa officinalis L.: Not exclusively anti-anxiety

From 2022 this comprehensive review analyzes the properties of this plant updating currently available literature, with a special emphasis on human studies. Providing compositional insights related to specific actions as an antioxidant, anti-inflammatory, antispasmodic, antimicrobial, neuroprotective, nephroprotective, antinociceptive effects. Making it helpful in the management of and against different human diseases, such as anxiety, sleeping …

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L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial

This 2019 randomized double blind, placebo controlled study followed 44 subjects with Generalised Anxiety disorder (GAD) resistant to their current antidepressant medications. While this study did not demonstrate statistical significant in primary outcomes (sleep, cognition, and anxiety rating) over placebo there was an improvement in subjects self-reported sleep satisfaction. Further the researchers suggest that there …

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Anti-stress, behavioural and magnetoencephalography effects of an L-Theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial

In a double-blind, placebo-controlled, balanced crossover study, the effects of 200 mg L-theanine on stress were measured using magnetoencephalography (MEG). Participants (n=34) were put under stressful scenarios and evaluated for markers of stress, including brain waves, salivary cortisol and the State-Trait Anxiety Inventory questionnaire. Two hours after administration those categorized as “high anxiety” showed a …

Anti-stress, behavioural and magnetoencephalography effects of an L-Theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial Read More »

Effects of chronic l-theanine administration in patients with major depressive disorder: An open-label study

In an open-label study, 20 participants with major depressive disorder were given 250 mg of l-theanine daily in addition to their current medication. Treatment lasted 8 weeks, at the end of which Hamilton Depression Rating scores decreased significantly. Other benefits included significantly decreased anxiety scores, and improved sleep scores and measurements of cognition after treatment …

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The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial

A 2012, double-blind randomized clinical trial aimed to determine the efficacy of Mg supplementation to improve insomnia in the elderly. In this study, 46 elderly subjects were randomly allocated into the Mg or the placebo group and received 500 mg magnesium or placebo daily for eight weeks. Supplementation of Mg appears to improve subjective measures …

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The role of magnesium in neurological disorders

In a recent 2018 review of the literature, researchers have investigated magnesium research across neurological conditions. Current literature has been reviewed for migraine, chronic pain, epilepsy, Alzheimer’s, Parkinson’s and stroke, as well as the commonly comorbid conditions of anxiety and depression. References: Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. …

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Melatonin: Pharmacology, functions and therapeutic benefits

Ingestion of melatonin induces fatigue, sleepiness, and a diminution of sleep latency. Therapeutic effects of melatonin have also been reported in several disorders such as certain tumors, cardiovascular diseases or psychiatric disorders. Melatonin plays a major role in the regularity and synchronization of central and peripheral oscillators allowing the development of harmonious internal functioning and …

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Delayed sleep on melatonin (DelSoM) study group. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

This randomised, placebo-controlled, double-blind clinical trial tested the efficacy of 0.5 mg melatonin, combined with behavioural sleep-wake scheduling, for improving sleep initiation in 116 clinically diagnosed DSWPD patients with a delayed endogenous melatonin rhythm relative to patient-desired (or -required) bedtime (DBT). References: Sletten TL, Magee M, Murray JM, Gordon CJ, Lovato N, Kennaway DJ, Gwini …

Delayed sleep on melatonin (DelSoM) study group. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial Read More »

A review of sleep disorders and melatonin

This 2016 narrative review aims to provide a comprehensive overview of various therapeutic functions of melatonin in insomnia, sleep-related breathing disorders, hypersomnolence, circadian rhythm sleep–wake disorders and parasomnias. Melatonin was found to offer an alternative treatment to the currently available pharmaceutical therapies for sleep disorders with significantly less side effects. References: Xie Z, Chen F, …

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