Stress

Body weight management in adults under chronic stress through treatment with ashwagandha root extract: A double-blind, randomized, placebo-controlled trial.

This study published in 2017 examined the role of ashwagandha (n=25, placebo n=25) in reducing perceived stress and subsequent weight gain in healthy subjects over eight weeks of supplementation. The results indicated statistically significant improvements in both the primary and secondary measures as compared to placebo. Indicating this may be a good option for management …

Body weight management in adults under chronic stress through treatment with ashwagandha root extract: A double-blind, randomized, placebo-controlled trial. Read More »

Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical Study.

This 2019, eight week randomised double-blind placebo controlled study of 58 participants examined the dose dependent effects of aqueous ashwagandha root extract on otherwise healthy participants facing stress and anxiety. The 300 mg group had the most pronounced decrease in Perceived Stress Scale (PSS) scores from baseline. References: Salve J, Pate S, Debnath K, Langade …

Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical Study. Read More »

A randomized, double blind placebo controlled study of efficacy and tolerability of Withania somnifera extracts in knee joint pain.

This study from 2016 is a randomized double-blind placebo-controlled trial, testing the dose-dependent effects of W. somnifera in patients with knee joint pain and discomfort. At the end of 12 weeks the high dose (i.e., 250 mg BID) group showed improvements earlier at 4 weeks and had a more significant reduction in the VAS scores …

A randomized, double blind placebo controlled study of efficacy and tolerability of Withania somnifera extracts in knee joint pain. Read More »

Role of Withania somnifera (Ashwagandha) in the management of male infertility

From 2018 this comprehensive review assessed the available evidence supporting use of Withania somnifera extracts on the management of male fertility concerns. Specifically relating to semen quality, sperm count, motility and androgens. Authors concluded that preclinical evidence supports the reduction in oxidative stress related to male infertility and may offer a promising therapeutic option. References: …

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Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): Results of a placebo-controlled, cross-over clinical trial

Clinical trial in 2019, published in Obstetrics & Gynecology Science. Oxaloacetate acid could be helpful in decreasing depression, perceived stress, anxiety, aggression and suicidal ideation caused by PMS. References: Tully, L., Humiston, J., & Cash, A. (2020). Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial. Obstetrics & Gynecology …

Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): Results of a placebo-controlled, cross-over clinical trial Read More »

Feverfew (Tanacetum parthenium L.): A systematic review

From 2011 this comprehensive review of the composition, preclinical and clinical evidence of feverfew was evaluated. Authors cite evidence for anti-inflammatory and analgesic responses. References: Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev. 2011 Jan;5(9):103-10. doi: 10.4103/0973-7847.79105. PMID: 22096324; PMCID: PMC3210009.

Natural herbal non-opioid topical pain relievers -Comparison with traditional therapy

In 2022 researchers reviewed the analgesic effects of a number of natural pain remedies including feverfew. Citing evidence of main compounds and composition, historical use as well as emerging clinical use in migraines. Patients using feverfew for up to six months of treatment reported fewer headaches, according to a study involving eight individuals who received …

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A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages

The purpose this 2020 review was to chemically characterize E. senticosus root and bark extracts and to compare their effects on functions of human primary macrophages. The ability of E. senticosus root and bark extracts to promote polarization of human macrophages towards anti-inflammatory M2a and M2b phenotypes, respectively, might underlay the immunoregulatory activities and point …

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Combined treatment with two water extracts of Eleutherococcus senticosus leaf and rhizome of drynaria fortunei enhances cognitive function: A placebo-controlled, randomized, double-blind study in healthy adults

In 2020 researchers performed a placebo-controlled, randomized, double-blind study to evaluate cognitive enhancement and anti-stress effects by the intake of a combined extract in healthy volunteers. The intake period was 12 weeks. The combined treatment of ES and DR extracts significantly increased the figure recall subscore of RBANS (p = 0.045) in an intergroup comparison. …

Combined treatment with two water extracts of Eleutherococcus senticosus leaf and rhizome of drynaria fortunei enhances cognitive function: A placebo-controlled, randomized, double-blind study in healthy adults Read More »

Flax terpenoid pathway as a source of health promoting compounds

This 2013 review highlights evidence demonstrating the health promoting agents derived from flax involving cell signaling and direct antioxidation, as a promising target for medicine and pharmacotherapy. References: Styrczewska M, Kulma A, Kostyn K, Hasiewicz-Derkacz K, Szopa J. Flax terpenoid pathway as a source of health promoting compounds. Mini Rev Med Chem. 2013 Mar;13(3):353-64. PMID: …

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