Systematic review

Effect of bergamot on lipid profile in humans: A systematic review

This systematic review published in 2020 reviewed 12 articles related to the lipid modifying properties of bergamot extracts. Authors reported most studies demonstrated a significant decrease in total cholesterol (12.3% to 31.3%,), triglycerides (11.5% to 39.5%) and LDLc (7.6% to 40.8%). Eight trials reported HDLc increase after intervention with bergamot. References: Lamiquiz-Moneo, I., Giné-González, …

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A systematic review on the cardiovascular pharmacology of Melica officinalis Gaertn.

This systematic review of clinical trials evaluating the effect of Amla on cardiovascular pharmacology was published in 2018. It included 19 cell culture, animal and human clinical studies with the terms “antioxidant, arrhythmia, cardioprotective, cardiotoxicity, heart disease, heart failure, hyperlipidemia, hypertension, myocardial dysfunction and oxidative stress”. References: Hashem-Dabaghian, F., Ziaee, M., Ghaffari, S., Nabati, F., …

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β-Carotene and other carotenoids in protection from sunlight

This systematic review published in 2012 provides key insights into the use of carotid micronutrients in the prevention of cellular UV damage. Photoprotection from carotenoids seems to relate to the ability to absorb UV light, diverting light from damaging the cellular structures. Authors suggest that while the evidence for topical use alone is insufficient to …

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Systematic review of carotenoid concentrations in human milk and infant blood

This systematic review published in 2022 defined the carotenoid concentrations in infant blood and human milk highlighting the importance on human health and development and defining nutritional requirements. Carotenoids: b-carotene, lutein, lycopene, and b-cryptoxanthin were the most commonly reported. References: Zaidi, Y., Stroh, R., & Moran, N. E. (2022). Systematic review of carotenoid concentrations in …

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A mechanistic review of β-carotene, lutein and zeaxanthin in eye health and disease

This systematic review from 2020 outlined mechanisms of action and related evidence of beta carotene’s benefits to ocular health. Outlining the role in preventing oxidative damage to various eye structures and prevention of diseases such as age-related macular degeneration, cataracts and diabetic retinopathy. The review includes 26 clinical trials whereby carotenoids were assessed for ocular …

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