Vision

A mechanistic review of β-carotene, lutein and zeaxanthin in eye health and disease

This systematic review from 2020 outlined mechanisms of action and related evidence of beta carotene’s benefits to ocular health. Outlining the role in preventing oxidative damage to various eye structures and prevention of diseases such as age-related macular degeneration, cataracts and diabetic retinopathy. The review includes 26 clinical trials whereby carotenoids were assessed for ocular …

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Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights

This review, published in 2020, reviewed all the published evidence – preclinical and clinical – for the use of astaxanthin for ocular health. Preclinical evidence supports the use of astaxanthin in the prevention and treatment of glaucoma, cataracts, keratopathy and dry eyes. References:  Giannaccare, G., Pellegrini, M., Senni, C., Bernabei, F., Scorcia, V., & Cicero, …

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Effects of lutein supplementation in age-related macular degeneration

To clarify inconsistencies in literature on the effects of Lutein on eye health, Feng et. al reviewed nine randomized clinical trials on a total of 920 eyes, of which 855 had age-related macular degeneration (AMD) for this meta-analysis. Lutein supplementation was shown to have increases in MPOD (macular pigment optical density), visual acuity and contrast …

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Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, crossover study

This placebo controlled, double blind, randomized, cross over study on the effects of lycopene rich tomato nutrient complex (TNC) and lutein, assessed for protection against ultraviolet radiation at the molecular level. The results were assessed for the capacity of the treatment groups to decrease the expression of UVA1 radiation inducible genes. The assumption here is …

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, crossover study Read More »

Let food be your medicine: Nutraceutical properties of lycopene

This 2019 review examines primary research and clinical trials involving lycopene and its impact on human health. The authors examine how the chemical structure of lycopene makes it a strong antioxidant, which is the basis for its health-promoting properties. Further authors examine clinical use in patients with prostate cancer, infertility, metabolic syndrome and liver damage. …

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Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

This 2017 systematic review and meta-analysis evaluated evidence from intervention trials on the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function. 21 publications were included and were meta-analysed. Overall, interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, IL-6, and improvements in FMD; while lycopene supplementation reduced systolic-BP. References: …

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Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops

This was a randomized, double-blind, placebo-controlled study. The purpose of this study was to examine using the original halometer glare test of the type of visual impairment mediated by the increased glare sensitivity (halos) and associated with poorer visual function in both the better and worse eyes of older adult drivers and older drivers with …

Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops Read More »

Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation

This 12 week double-blind, placebo-controlled trial from 2016 was a pilot study to understand the retinal impacts of supplementation with macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ.) Twenty-eight healthy subjects, aged 18-25 yo participated and were assigned to one of four daily supplementation groups: placebo (safflower oil; n = 5), 7.44 mg total …

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The pharmacological effects of lutein and zeaxanthin on visual disorders and cognition diseases

This 2017 review of carotenoids aimed to synthesize the available literature that has led the scientific community to believe that carotenoids lutein and zeaxanthin have broad uses for visual and cognitive health as they are selectively absorbed and sequestered in the retina. These carotenoids are thought to have excellent antioxidant, blue light filtration and contrast …

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Illuminating the role of vitamin A in skin innate immunity and the skin microbiome: A narrative review

This narrative review from 2021 summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome. Deficiencies in vitamin A have been linked to an increased susceptibility to skin infection and inflammation. References: Roche FC, Harris-Tryon TA. …

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