This randomized, placebo-controlled clinical study from 2016 aimed to evaluate the effect of a combination of folic acid, myo-inositol (MI) and D-chiro inositol (DCI) in young overweight women with polycystic ovary syndrome (PCOS), characterized by anovulation and hyperandrogenism, correlated to insulin resistance. Participants received either a placebo or folic acid (200 μg) + MI (550 mg) + DCI (13.8 mg) twice daily for six months. The results show a statistically significant reduction of LH, free testosterone, fasting insulin and HOMA index in the combination therapy group, compared to the placebo.
Benelli E, Del Ghianda S, Di Cosmo C, Tonacchera M. A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Int J Endocrinol. 2016;2016:3204083. doi: 10.1155/2016/3204083. Epub 2016 Jul 14. PMID: 27493664; PMCID: PMC4963579.