A combined therapy with myo-inositol and D-chiro-inositol improves endocrine parameters and insulin resistance in PCOS young overweight women 

This randomized, placebo-controlled clinical study from 2016 aimed to evaluate the effect of a combination of folic acid, myo-inositol (MI) and D-chiro inositol (DCI) in young overweight women with polycystic ovary syndrome (PCOS), characterized by anovulation and hyperandrogenism, correlated to insulin resistance. Participants received either a placebo or folic acid (200 μg) + MI (550 mg) + DCI (13.8 mg) twice daily for six months. The results show a statistically significant reduction of LH, free testosterone, fasting insulin and HOMA index in the combination therapy group, compared to the placebo.  

References:

Benelli E, Del Ghianda S, Di Cosmo C, Tonacchera M. A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Int J Endocrinol. 2016;2016:3204083. doi: 10.1155/2016/3204083. Epub 2016 Jul 14. PMID: 27493664; PMCID: PMC4963579.