A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression 

In a 2017 double-blind, placebo-controlled study, 60 new mothers with mild-to-moderate post-partum depression were randomized to receive 15 mg twice daily of saffron or placebo. After eight weeks of treatment, the women given saffron had significantly decreased depression scores compared to the placebo group. 96% of the saffron group achieved remission compared to only 43% of the placebo group. 

References:

abeshpour J, Sobhani F, Sadjadi SA, et al. A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression. Phytomedicine. 2017;36:145-152. doi:10.1016/j.phymed.2017.10.005