Univestin™ has over 15 human clinical studies and in a randomized, double-blind, placebo-controlled trial, going head to head with common over the counter NSAIDS in relieving joint pain, stiffness and joint immobility in subjects with OA. On the basis of these positive observations, it was concluded that the mechanism of dual COX/LOX inhibition may confer clinical safety and efficacy benefits comparable and, in some cases superior to traditional NSAIDs, without the side effects.
Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food. 2007 Sep;10(3):442-51. doi: 10.1089/jmf.2006.255. PMID: 17887937.