A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes 

In this randomized, controlled trial, researchers aimed to assess the effect of D-chiro-inositol and folic acid supplementation on glucose control and insulin resistance in overweight/obese patients with type I diabetes.   

DCI and folic acid supplementation led to a significant reduction in HbA1C levels, compared to the control group, suggesting that DCI and folic acid supplementation can improve metabolic control in overweight patients with type I diabetes. 

References:

Maurizi AR, Menduni M, Del Toro R, Kyanvash S, Maggi D, Guglielmi C, Pantano AL, Defeudis G, Fioriti E, Manfrini S, Pozzilli P. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017 Apr;54(4):361-365. doi: 10.1007/s00592-016-0954-x. Epub 2016 Dec 30. PMID: 28039583.