Cardioprotection and lifespan extension by the natural polyamine spermidine 

This 2016 animal study also included a prospective population based cohort where human consumption of spermidine was assessed in relation to prevalence of cardiovascular events.  

We also provide evidence that dietary spermidine intake in humans inversely correlates with cardiovascular disease. Authors found intake was 

inversely associated with the risk of both fatal heart failure (a 

~40% reduction in risk in the high compared to low spermidine intake groups) and clinically 

overt heart failure; both risks were more pronounced in men. 

References:

Eisenberg, T., et al. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature medicine, 22(12), 1428–1438. https://doi.org/10.1038/nm.4222